Capillary electrophoresis with end-column electrochemiluminescence for ultrasensitive determination of urapidil hydrochloride in rat plasma and its application to pharmacokinetics study

Sun, Shi‐Gang; Wei, Yanfen; Long, Chanjuan; Deng, Biyang

doi:10.1016/j.jchromb.2015.10.011

Cited by 11 publications

(1 citation statement)

References 29 publications

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“…UV-vis and flow-injection chemiluminescence [ 3 , 4 ] was first employed, but it suffered from low detection limit and narrow linear range. Recently, several analytical methods, such as high performance liquid chromatography (HPLC) [ 5 ], liquid chromatography-mass spectrometry (LC-MS) [ 6 , 7 ], capillary electrophoresis (CE) [ 8 ], and atomic absorption spectrometery (AAS) [ 9 ], have been also proposed for determination of urapidil. Although these methods have some advantages of accuracy and sensitivity, they require tedious pretreatment procedures, or complicated pre-separation processes, at high cost.…”

Section: Introductionmentioning

confidence: 99%

3D Graphene-Nitrogen Doped Carbon Nanotubes Network Modified Electrode as Sensing Materials for the Determination of Urapidil

Zhou

Yang

et al. 2018

Materials

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In this work, a three dimensional (3D) graphene-nitrogen doped carbon nanotubes (G-NCNTs) network was successfully fabricated on the surface of a glassy carbon (GC) electrode using the pulse potential method (PPM) in a graphene oxide-nitrogen doped carbon nanotubes (GO-NCNTs) dispersion. The morphological and characteristics of GO-NCNTs and G-NCNTs nanocomposites were investigated by atomic force microscopy (AFM), scanning electron microscopy (SEM), UV-vis spectroscopy, Raman spectroscopy, and electrochemical experiments. The 3DG-NCNTs network was applied as a new voltammetric material for the fabrication of an electrochemical platform for determination of urapidil. Systematic electrochemical tests demonstrate that the 3DG-NCNTs network modified GC electrode can effectively increase the response to the oxidation of urapidil. Under the optimum conditions, the electrochemical response was linear with urapidil concentrations in the range of 1.0 × 10−8~2.0 × 10−6 mol·L−1, while a low detection limit of 5.0 × 10−9 mol·L−1 was obtained for urapidil. Moreover, the proposed sensing platform exhibited good results for sensitivity, reproducibility, selectivity, and stability, which makes it very suitable for use as an ideal inexpensive and rapid analytical method applicable for complex drug matrices.

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