Capillary electrophoresis microchip coupled with on-line chemiluminescence detection

Su, Rongguo; Lin, Jin‐Ming; Qu, Feng; Chen, Zhifeng; Gao, Yunhua; Yamada, Masaaki

doi:10.1016/j.aca.2003.11.080

Cited by 44 publications

(25 citation statements)

References 25 publications

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“…In contrast, chemiluminescence reactions with neurotransmitters such as dopamine and serotonin have been studied extensively using several different permanganate (23)(24)(25)(26)(27)(28)(29) and luminol (30)(31)(32)(33)(34)(35)(36) systems and also with soluble manganese(IV) (20,21). Protocatechuic acid and caffeic acid are related dihydroxybenzenes that were identified as strong enhancers of the chemiluminescence from luminol and hexacyanoferrate(III) in previous studies (17,37).…”

Section: Selection Of Phenolic Compoundsmentioning

confidence: 99%

Selectivity and potential interference from phenolic compounds in chemiluminescence methods for the determination of synephrine

et al. 2008

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Three recently reported chemiluminescence methods (based on reactions with alkaline luminol and hexacyanoferrate(III); acidic cerium(IV) and rhodamine B; and acidic permanganate with polyphosphates) for the determination of synephrine were re-evaluated in terms of their selectivity towards this analyte in comparison to other phenolic compounds. A fourth reagent system, acidic soluble manganese(IV) and formaldehyde, was also examined. Each set of reagents was sensitive towards synephrine (limits of detection were 3 × 10 -9 , 5 × 10 -8 , 1 × 10 -8 and 1 × 10 -8 mol/L, respectively) but also responded with numerous other phenolic compounds, including some that are present in citrus fruit extracts, dietary supplements and/or biological fluids. It is therefore recommended that the determination of synephrine in these matrices should incorporate physical separation of sample components (e.g. chromatography or electrophoresis). In more general terms, this study illustrates that accurate percentage recoveries for an analyte in spiked samples (without validation against another analytical method) are insufficient to confirm the analytical utility of new flow-injection analysis (FIA) procedures.

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Section: Selection Of Phenolic Compoundsmentioning

confidence: 99%

Selectivity and potential interference from phenolic compounds in chemiluminescence methods for the determination of synephrine

et al. 2008

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“…Satisfactory sensitivity and low RSD for migration time and peak height were obtained. Using also permanganate as CL system, a microchip was designed on the principle of flow-injection CL-CE, including three main channels, five reservoirs and a detection cell [162]. As model samples, dopamine and catechol were sensitive and rapidly separated and detected.…”

Section: Direct Oxidationsmentioning

confidence: 99%

Advances and analytical applications in chemiluminescence coupled to capillary electrophoresis

2010

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Advances and analytical applications in chemiluminescence coupled to capillary electrophoresisThe present review presents the state of the art of the developments, key strategies and analytical applications of chemiluminescence detection coupled to CE (CE-CL). Different parts considering the most common CL systems have been included, such as the tris(2,2 0 -bipyridine)ruthenium(II) system, the luminol and derivatives reaction, the peroxyoxalate CL or direct oxidations. New advances in homemade configurations and applications in different fields such as clinical, pharmaceutical, environmental and food analysis have been included. The focus is on studies which appeared from 2000 to the end of 2009.

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“…Su et al [79] integrated a CL detector with electrophoretic separation on a glass microchip. Dopamine and catechol were separated first and then detected using a permanganate CL system.…”

Section: Chemiluminescence and Electrochemiluminescence Detectionmentioning

confidence: 99%

Unconventional detection methods for microfluidic devices

2006

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The direction of modern analytical techniques is to push for lower detection limits, improved selectivity and sensitivity, faster analysis time, higher throughput, and more inexpensive analysis systems with ever-decreasing sample volumes. These very ambitious goals are exacerbated by the need to reduce the overall size of the device and the instrumentation -the quest for functional micrototal analysis systems epitomizes this. Microfluidic devices fabricated in glass, and more recently, in a variety of polymers, brings us a step closer to being able to achieve these stringent goals and to realize the economical fabrication of sophisticated instrumentation. However, this places a significant burden on the detection systems associated with microchip-based analysis systems. There is a need for a universal detector that can efficiently detect sample analytes in real time and with minimal sample manipulation steps, such as lengthy labeling protocols. This review highlights the advances in uncommon or less frequently used detection methods associated with microfluidic devices. As a result, the three most common methods -LIF, electrochemical, and mass spectrometric techniques -are omitted in order to focus on the more esoteric detection methods reported in the literature over the last 2 years.

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Capillary electrophoresis microchip coupled with on-line chemiluminescence detection

Cited by 44 publications

References 25 publications

Selectivity and potential interference from phenolic compounds in chemiluminescence methods for the determination of synephrine

Selectivity and potential interference from phenolic compounds in chemiluminescence methods for the determination of synephrine

Advances and analytical applications in chemiluminescence coupled to capillary electrophoresis

Unconventional detection methods for microfluidic devices

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