Capillary electrophoresis–electrochemiluminescent detection of N,N-dimethyl ethanolamine and its application in impurity profiling and stability investigation of meclophenoxate

Pharmacokinetics of Propranolol Hydrochlorid in Human Urine by Capillary Electrophoresis Coupled with Electrochemiluminescence

“…16,[18][19][20][21][22][23][24] In this research, it was found that the weak ECL signal from the electrochemical oxidization of Ru(bpy)3 2+ was greatly enhanced by PRO. Based on this observation, CE coupled with ECL detection was used for the determination of the pharmacokinetics of PRO in human urine.…”

Electrogenerated Chemiluminescence

“…The value of TDS 0 is usually estimated as 0.1 (±0.1) eV [60][61][62]. Frequently, the criterion is given based on CV peak potentials (in volts) at T = 298 K as Eq.…”

Applications of Electrochemiluminescence

“…Thus, the detection of amine impurity is of great importance in drug quality control of these amino group-containing ester and amide. Another CE method coupled with end-column ECL based on Ru(bpy) 3 2+ system is used for the analysis of N,N-dimethyl ethanolamine, the degradation product of meclofenoxate, with a detection limit of 2.0 9 10 -8 mol L -1 at the S/N = 3 [62]. For tricyclic antidepressants Imi and Tri, CE method was used in combination with Ru(bpy) 3 2+ end-column ECL detection which was successfully applied for the determination of Imi in pharmaceutical dosage form.…”