Capillary blood, an alternative to saliva for the diagnosis of Cushing's syndrome?

Belaidi, N.; Mimouni, S; Ourioux, Cécile; Gatta, Blandine; Corcuff, Jean-Benoı̂t

doi:10.1016/j.cca.2007.04.025

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…Our study was designed with 17-OHP/ cortisol ratio as the main measure. These analytes were measured in total capillary blood, thus comparison with assays in venous serum should take this into account [14]. We found that serum 17-OHP/cortisol concentrations ratio remained constant in the youngest infants aged less than 32 weeks of corrected PMA.…”

Section: Discussionmentioning

confidence: 89%

Plasma 17-hydroxyprogesterone/cortisol ratio is not a predictor of systemic hypotension in extremely premature infants

Lacoste¹,

Corcuff²,

Bénard³

et al. 2013

OJPed

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Background/aims: To determine whether the 17-hydroxyprogesterone (17-OHP)/cortisol ratio as a marker of immature11-beta hydroxylase activity can predict severe systemic hypotension in preterm neonates. Methods: Serum cortisol and 17-OHP concentrations were measured in capillary blood deposited on blotter paper on day 3 post-natal age (Day 3) in infants less than 32 weeks postmenstrual age (PMA). The predictive value of 17-OHP/cortisol ratio for a first episode of systemic hypotension occurring after Day 3 (FESH) was evaluated. Results: Of 105 infants included, 14 patients (13%) presented a FESH. Neither the 17-OHP/cortisol ratio, nor the 17-OHP or cortisol concentrations were associated with the occurrence of a FESH when adjusted for potential confounding factors. 17-OHP and cortisol were inversely associated to PMA (r = ﹣0.36 and ﹣0.40, respectively). Cortisol, but not 17-OHP, was associated with the type of hospitalization unit, the respiratory support and the presence of a patent ductus arteriosus. The 17-OHP/cortisol ratio was associated with the type of hospitalization unit only. Conclusions: The 17-OHP/ cortisol ratio at Day 3 did not predict the occurrence of a first episode of systemic hypotension after Day3 inpreterm neonates.

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Section: Discussionmentioning

confidence: 89%