Capecitabine (X) in elderly patients (pts) with hormone-refractory metastatic breast cancer (MBC)

Longo, F.; Magnolfi, E.; Borgomastro, A.; Gemma, Daniele; Salerno, Massimiliano; Ciorra, A. Alida; Traficante, D.; Seri, M. Di

doi:10.1200/jco.2004.22.90140.839

Cited by 1 publication

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“…Recent studies by Longo et al [31] and Zamora et al [28] have shown that single-agent capecitabine is safe and active for the treatment of elderly patients with metastatic breast cancer who were previously treated with chemotherapy. Although there were no CRs, 20%-28% of elderly patients in those studies exhibited a partial response to single-agent capecitabine, and another 44%-50% exhibited SD, similar to the ORRs and SD rates observed overall in studies of single-agent capecitabine for second-line metastatic breast cancer.…”

Section: Elderly Patientsmentioning

confidence: 99%

“…Although there were no CRs, 20%-28% of elderly patients in those studies exhibited a partial response to single-agent capecitabine, and another 44%-50% exhibited SD, similar to the ORRs and SD rates observed overall in studies of single-agent capecitabine for second-line metastatic breast cancer. Dose reduction was needed for patients treated with capecitabine at a dose of 1,250 mg/m 2 bid [28] but not for those treated with 1,000 mg/m 2 bid [31]. The incidence of grade 3 HFS was greater with 1,250 mg/m 2 bid dosing than with 1,000 mg/m 2 dosing (18% vs. 7%), as was the incidence of grade 3 or 4 mucositis (12% vs. 7%).…”

Section: Elderly Patientsmentioning

confidence: 99%

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Capecitabine Monotherapy: Safe and Effective Treatment for Metastatic Breast Cancer

Ershler

2006

The Oncologist

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After completing this course, the reader will be able to:1. Describe the pharmacology of capecitabine.2. Discuss the use of capecitabine as a single agent and in refractory disease. AbstractOptimal management for metastatic breast cancer frequently involves cytotoxic chemotherapy. Over the years, several complex multidrug regimens have been developed that were based upon a rationale of synergistic antitumor activity and nonoverlapping toxicities. However, recently the clinical value of these complex regimens has been called into question as several drugs used alone (monotherapy) or in sequence (serial single agent) have been shown to be both efficacious and better tolerated. Capecitabine (an orally administered fluoropyrimidine carbamate) is one such agent that has been proven to be effective when used alone for metastatic breast cancer, metastatic colorectal cancer, and adjuvant colon cancer. In this review, published (or reported in abstract form) data examining various aspects of clinical response and tolerability with single-agent capecitabine for (primarily) first-and second-line metastatic breast cancer are examined. For the most part, response rates are comparable with those of the more complex regimens. Dose reductions from the labeled dose of 1,250 mg/m 2 twice daily are relatively common. Toxicities (following dose reductions if needed) are generally manageable, even by more frail patients. Elderly patients are more likely to have impaired renal function or be receiving warfarin treatment, and special attention to these factors is warranted. Nonetheless, the drug administered alone is a reasonable choice when singleagent chemotherapy is entertained as a treatment option for metastatic breast cancer, including in the first-line setting. The Oncologist 2006;11:325-335

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Section: Elderly Patientsmentioning

confidence: 99%

Section: Elderly Patientsmentioning

confidence: 99%