Capecitabine Initially Concomitant to Radiotherapy Then Perioperatively Administered in Locally Advanced Rectal Cancer

Zampino, Maria Giulia; Magni, Elena; Leonardi, Maria Cristina; Petazzi, Elena; Santoro, Luigi; Luca, Fabrizio; Chiappa, Antonio; Petralia, Giuseppe; Trovato, C.; Fazio, Nicola; Orecchia, Roberto; Nolè, Franco; Braud, Filippo de

doi:10.1016/j.ijrobp.2008.11.002

Cited by 36 publications

(26 citation statements)

References 46 publications

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“…Although several studies reported induction chemotherapy compliance rates of at least 94 per cent, disappointingly, pCR rates did not differ significantly from those associated with the conventional approach. In contrast, Gao and colleagues and Yu et al .…”

Section: Discussionmentioning

confidence: 82%

“…The majority reported distant failure rates in keeping with the conventional treatment paradigm (19–31 per cent). Two studies reported significantly lower rates (5 and 6 per cent respectively). As clinical stage, compliance and the use of adjuvant therapy did not differ greatly, this discrepancy may be related to the shorter length of follow‐up in these two studies.…”

Section: Discussionmentioning

confidence: 86%

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Systematic review of outcomes after total neoadjuvant therapy for locally advanced rectal cancer

Zaborowski

Stakelum

Winter

2019

British Journal of Surgery

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Background Advances in surgical technique and the development of combined‐modality therapy have led to significantly improved local control in rectal cancer. Distant failure rates however, remain high, ranging between 20 and 30 per cent. Additional systemic chemotherapy in the preoperative period has been proposed as a means of eradicating subclinical micrometastases and improving long‐term survival. The purpose of this systematic review was to evaluate the current evidence regarding induction chemotherapy in combination with standard neoadjuvant chemoradiotherapy, in terms of oncological outcomes, in patients with rectal cancer. Methods A systematic review of the literature was performed to evaluate oncological outcomes and survival in patients with rectal cancer who underwent induction chemotherapy and neoadjuvant chemoradiotherapy, followed by surgical resection. Four major databases (PubMed, Embase, Scopus and Cochrane) were searched. The review included all original articles published in English reporting long‐term outcomes, specifically survival data, and was limited to prospective studies only. Results A total of 686 studies were identified. After applying inclusion and exclusion criteria, ten studies involving 648 patients were included. Median follow‐up was 53·7 (range 26–80) months. Five‐year overall and disease‐free survival rates were 74·4 and 65·4 per cent respectively. Weighted mean local recurrence and distant failure rates were 3·5 (range 0–7) and 20·6 (range 5–31) per cent respectively. Conclusion Total neoadjuvant therapy should be considered in patients with high‐risk locally advanced rectal cancer owing to improved chemotherapy compliance and disease control. Further prospective studies are required to determine whether this approach translates into improved disease‐related survival or increases the proportion of patients suitable for non‐operative management.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 86%

Systematic review of outcomes after total neoadjuvant therapy for locally advanced rectal cancer

Zaborowski

Stakelum

Winter

2019

British Journal of Surgery

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“…However, ‘overall survival’ was defined in only 20 studies with six different definitions . ‘Disease‐free survival’ was reported in 43 (22.2%) articles and defined in 27 with 16 unique definitions . The most commonly used measures of short‐term operative mortality were ‘30‐day mortality’ and ‘postoperative mortality’, which were reported in 16 (8.2%) and 14 (7.2%) of the included publications, respectively.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of outcome reporting in colorectal cancer surgery

Whistance¹,

Forsythe²,

McNair³

et al. 2013

Colorectal Disease

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Method Systematic literature searches identified randomized and nonrandomized prospective studies reporting clinical outcomes of CRC surgery. Outcomes were listed verbatim, categorized into broad groups (outcome domains) and examined for a definition (an appropriate textual explanation or a supporting citation). Outcome reporting was considered inconsistent if results of the outcome specified in the methods were not reported. Outcome reporting was compared between randomized and nonrandomized studies.Results Of 5644 abstracts, 194 articles (34 randomized and 160 nonrandomized studies) were included reporting 766 different clinical outcomes, categorized into seven domains. A mean of 14 AE 8 individual outcomes were reported per study. 'Anastomotic leak', 'overall survival' and 'wound infection' were the three most frequently reported outcomes in 72, 60 and 44 (37.1%, 30.9% and 22.7%) studies, respectively, and no single outcome was reported in every publication. Outcome definitions were significantly more often provided in randomized studies than in nonrandomized studies (19.0% vs 14.9%, P = 0.015). One-hundred and twenty-seven (65.5%) papers reported results of all outcomes specified in the methods (randomized studies, n = 21, 61.5%; nonrandomized studies, n = 106, 66.2%; P = 0.617).Conclusion Outcome reporting in CRC surgery lacks consistency and method. Improved standards of outcome measurement are recommended to permit data synthesis and transparent cross-study comparisons.

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“…Even though several trials showed an equivalence between 5-FU continuous perfusion and capecitabine (43) and although many phase II studies (44)(45)(46) showed efficacy of this molecule, capecitabine has not been validated by phase III studies. In our study, capecitabine induced more tumor response than 5-FU did.…”

Section: Discussionmentioning

confidence: 99%

Predictive Factors of Tumor Response After Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer

Moureau-Zabotto

Farnault

Chaisemartin

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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Capecitabine Initially Concomitant to Radiotherapy Then Perioperatively Administered in Locally Advanced Rectal Cancer

Cited by 36 publications

References 46 publications

Systematic review of outcomes after total neoadjuvant therapy for locally advanced rectal cancer

Systematic review of outcomes after total neoadjuvant therapy for locally advanced rectal cancer

A systematic review of outcome reporting in colorectal cancer surgery

Predictive Factors of Tumor Response After Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer

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