Capacity analysis for diffusive molecular communication with ISI channel

Cheng, Zhen; Zhu, Yi-hua; Chi, Kaikai; Li, Yanjun; Xia, Ming

doi:10.1016/j.nancom.2017.07.002

Cited by 15 publications

(12 citation statements)

References 20 publications

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“…2) The exponential curve is a natural fit for the considered phenomenon. When there is a large number of transmitted potassium ions, the distribution of the received ions at the receiver can be approximated as a Poisson distribution [42]. This distribution belongs to the class of exponential families of distributions.…”

Section: Numerical Simulation Resultsmentioning

confidence: 99%

“…The ISI can be eliminated unless the signal propagation duration is infinite. One approach is to use a dynamic threshold detection technique [42]. We consider the ISI by taking into account the impact of the previously emitted ions, but simplify the detection procedure with a predefined threshold detection to avoid the computational burden.…”

Section: Relation Between the Ionic Injection And The Membrane Potmentioning

confidence: 99%

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Molecular Communication Aspects of Potassium Intracellular Signaling in Cardiomyocytes

Veletić

Bergsland

et al. 2020

IEEE Access

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Cardiovascular diseases continue to be a leading cause of morbidity and mortality worldwide. Cardiomyocytes, as the elementary heart components, play a crucial role in maintaining a healthy heart by coordinating contractions throughout the heart muscle that lead to a heartbeat. This study aims to characterize fine-grained ionic-level manipulation of cardiomyocytes for the controlled electrical activity that will offer new insights within the medical field. We explore the concept of Molecular Communications (MC) to analyze the propagation of potassium ions in the cardiomyocyte cytosol. By associating the number of the potassium ions in the cytosol with the membrane-and action potentials, we use metrics from the wellknown Shannon's information theory to optimize the ionic injection process and manipulate cardiomyocytes electrical activity. In case ON/OFF keying modulation is adopted as the potassium ion injection method, the optimal input distribution in terms of information capacity follows the derived Bernoulli distribution. This study offers underlying concepts that can be exploited in the creation of cardiomyocyte signals either for data communication via cellular infrastructure or heart pacing. The framework presented here needs to be upgraded in the following phases and made more physiologically plausible. INDEX TERMS Cardiomyocyte, channel capacity, intracellular communication, molecular communication, subthreshold communication.

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Section: Numerical Simulation Resultsmentioning

confidence: 99%

Section: Relation Between the Ionic Injection And The Membrane Potmentioning

confidence: 99%

Molecular Communication Aspects of Potassium Intracellular Signaling in Cardiomyocytes

Veletić

Bergsland

et al. 2020

IEEE Access

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“…where the subscript j varies from 1 and 4 depending on the level of the concentration that is being considered. The value of x i (t max ) is calculated by using (7). The term N i in 7is obtained by the multiplication of the volume of the receiver cell V RX and C i , i.e.…”

Section: A Parametersmentioning

confidence: 99%

“…Similarly, in [6] the authors analyze the capacity of the channel considering both the diffusion-based channel and the ligand-based receiver. Another work in [7] presents the analysis of the channel capacity in diffusive MC by considering intersymbol interference (ISI) from all the previous time slots and the channel transmission probability in each of them. The results in their work show that the channel capacity can be maximized with an optimal lower bit error probability by controlling the channel transmission probability in each time slot.…”

Section: Introductionmentioning

confidence: 99%

Upper and Lower Bounds of Constrained Capacity in Diffusion-based Molecular Communication

Ratti

Vakilipoor

Magarini

et al. 2020

2020 IEEE 21st International Workshop on Signal Processing Advances in Wireless Communications (SPAWC)

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This paper investigates upper and lower bounds for the constrained capacity of a diffusive molecular communication (MC) system in the case where the information is associated with the concentration of molecules released by the transmitter. The evaluation of channel capacity for the diffusive channel is an open problem in the context of MC. Here, two simple bounds of the constrained capacity are derived for a given number of input concentration levels. Numerical results are reported for binary and quadruple concentration-shift keying considering the Poisson and Gaussian distributions, which are two common approximations used to describe the statistics of the received signal. We show that for both the two statistical channel models the resulting bounds are tight and, therefore, this means that, at least for low modulation orders, it is not necessary to resort to numerical techniques or complicated analytical expressions to guess the capacity of the diffusive MC channel.

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“…Recently, studies on time-slotted communication systems for MC-based nanonetworks (MCN) have begun to emerge [4]- [7]. In it, time is divided into subunits called time-slots, where a transmitter nanomachine transmits a signal at the beginning of a time-slot, and the receiver nanomachine expects to receive the signal at an intended time-slot.…”

Section: Introductionmentioning

confidence: 99%

A Time-Slotted Molecular Communication (TS-MOC): Framework and Time-Slot Errors

2019

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Synchronization is a critical issue in molecular communications (MC). Additionally, the lack of an appropriate time-slotted framework for MC systems hinders the in-depth analysis of desynchronization. Therefore, this paper addresses both issues. First, taking inspiration from oscillators found in nature, we propose a time-slotted framework suitable for MC systems where the time instances of the oscillations demarcate the time-slot boundaries. The use of biological oscillators readily satisfies biocompatibility requirements. We name such system as a time-slotted molecular communication-based (TS-MOC) system. A TS-MOC system will be beneficial to many MC applications, such as when multiple nanomachines have to transmit data simultaneously to a control/sink node or share the channel in a time-division multiplexing manner. Second, oscillation perturbations induce desynchronization -the misalignment of time-slots. Desynchronization combined with large propagation delay results in a time difference between the arrival of a signal and the beginning of a time-slot. This phenomenon is called time-slot error, and it can degrade a system's performance. Therefore, the immediate goal is to mitigate time-slot errors. Depending on the initiation type, we propose two synchronization schemes: sender-initiated time-slot alignment and receiver-initiated time-slot alignment. An analytical model for time-slot error is also derived. Our analysis demonstrates that the proposed schemes are robust and energy-efficient -they achieve relatively low errors indicating robustness and relatively less synthesizing energy costs indicating energy efficiency. Our analysis also highlights the good agreement between the simulations and the analytical model. Finally, in conclusion, we provide brief insights into key open research challenges.

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Capacity analysis for diffusive molecular communication with ISI channel

Cited by 15 publications

References 20 publications

Molecular Communication Aspects of Potassium Intracellular Signaling in Cardiomyocytes

Molecular Communication Aspects of Potassium Intracellular Signaling in Cardiomyocytes

Upper and Lower Bounds of Constrained Capacity in Diffusion-based Molecular Communication

A Time-Slotted Molecular Communication (TS-MOC): Framework and Time-Slot Errors

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