Capacitively coupled contactless conductivity detection for microseparation techniques – recent developments

Kubáň, Pavel; Hauser, Peter C.

doi:10.1002/elps.201000354

Cited by 132 publications

(64 citation statements)

References 120 publications

(115 reference statements)

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“…Lithium from the body fluid sample is extracted by electric field through an SLM into an acidic acceptor solution, whereas high-molecular-weight matrix components are efficiently retained on this SLM. The acceptor solution is then analyzed by CE with capacitively coupled contactless conductivity detection (C 4 D) [35][36][37][38][39]. The CE-C 4 D method is optimized for baseline separation of lithium from other cations present in acceptor solutions and can be used for the determination of therapeutic and most endogenous concentrations of lithium in a complete set of untreated body fluids.…”

Section: Introductionmentioning

confidence: 99%

Rapid and simple pretreatment of human body fluids using electromembrane extraction across supported liquid membrane for capillary electrophoretic determination of lithium

2011

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Electromembrane extraction was used for simultaneous sample cleanup and preconcentration of lithium from untreated human body fluids. The sample of a body fluid was diluted 100 times with 0.5 mM Tris solution and lithium was extracted by electromigration through a supported liquid membrane composed of 1-octanol into 100 mM acetic acid acceptor solution. Matrix compounds, such as proteins, red blood cells, and other high-molecular-weight compounds were efficiently retained on the supported liquid membrane. The liquid membrane was anchored in pores of a short segment of a polypropylene hollow fiber, which represented a low cost, single use, disposable extraction unit and was discarded after each use. Acceptor solutions were analyzed using capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C(4) D) and baseline separation of lithium was achieved in a background electrolyte solution consisting of 18 mM L-histidine and 40 mM acetic acid at pH 4.6. Repeatability of the electromembrane extraction-CE-C(4) D method was evaluated for the determination of lithium in standard solutions and real samples and was better than 0.6 and 8.2% for migration times and peak areas, respectively. The concentration limit of detection of 9 nM was achieved. The developed method was applied to the determination of lithium in urine, blood serum, blood plasma, and whole blood at both endogenous and therapeutic concentration levels.

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Section: Introductionmentioning

confidence: 99%

Rapid and simple pretreatment of human body fluids using electromembrane extraction across supported liquid membrane for capillary electrophoretic determination of lithium

2011

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“…A recent review on CCD for microseparation systems was given by Kubáň and Hauser [113] discussing recent developments over the last two years. There is a clear trend towards the use of CCD because it is simple to implement and suited to miniaturization.…”

Section: Discussionmentioning

confidence: 99%

Review on the development of truly portable andin-situcapillary electrophoresis systems

Lewis

Cranny

Harris

et al. 2013

Meas. Sci. Technol.

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Capillary electrophoresis (CE) is a technique which uses an electric field to separate a mixed sample into its constituents. Portable CE systems enable this powerful analysis technique to be used in the field. Many of the challenges for portable systems are similar to those of autonomous in-situ analysis and therefore portable systems may be considered a stepping stone towards autonomous in-situ analysis. CE is widely used for biological and chemical analysis and example applications include: water quality analysis; drug development and quality control; proteomics and DNA analysis; counter-terrorism (explosive material identification) and corrosion monitoring. The technique is often limited to laboratory use, since it requires large electric fields, sensitive detection systems and fluidic control systems. All of these place restrictions in terms of: size, weight, cost, choice of operating solutions, choice of fabrication materials, electrical power and lifetime. In this review we bring together and critique the work by researchers addressing these issues. We emphasize the importance of a holistic approach for portable and in-situ CE systems and discuss all the aspects of the design. We identify gaps in the literature which require attention for the realization of both truly portable and in-situ CE systems.

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“…Conductometric detection, which detects all ionic compounds, is an alternative choice for glucosamine detection. Capacitively coupled contactless conductivity detection (C 4 D) is often utilized due to its compatibility with the CE system [25][26][27][28][29]. C 4 D detection can be performed on the capillary without the need of any special interface or loss of separation efficiency and resolution.…”

Section: Introductionmentioning

confidence: 99%

Direct injection of human serum and pharmaceutical formulations for glucosamine determination by CE-C4D method

Chaisuwan

Kongprasertsak

Sangcakul

et al. 2011

Journal of Chromatography B

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Capacitively coupled contactless conductivity detection for microseparation techniques – recent developments

Cited by 132 publications

References 120 publications

Rapid and simple pretreatment of human body fluids using electromembrane extraction across supported liquid membrane for capillary electrophoretic determination of lithium

Rapid and simple pretreatment of human body fluids using electromembrane extraction across supported liquid membrane for capillary electrophoretic determination of lithium

Review on the development of truly portable andin-situcapillary electrophoresis systems

Direct injection of human serum and pharmaceutical formulations for glucosamine determination by CE-C4D method

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