Capacitively coupled contactless conductivity detection for analytical techniques – Developments from 2018 to 2020

Hauser, Peter C.; Kubáň, Pavel

doi:10.1016/j.chroma.2020.461616

Cited by 46 publications

(28 citation statements)

References 120 publications

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“…The capacitively coupled contactless conductivity detection (C 4 D) method is an effective conductivity detection method for fluidic analysis and measurement [ 1 , 2 , 3 , 4 ]. Compared with traditional contact conductivity detection methods, the electrodes of the C 4 D sensor are not in direct contact with the measured fluid.…”

Section: Introductionmentioning

confidence: 99%

“…Compared with traditional contact conductivity detection methods, the electrodes of the C 4 D sensor are not in direct contact with the measured fluid. Hence, some unfavorable influence of contact conductivity detection methods (such as the electrode polarization and the electrochemical corrosion) can be avoided [ 1 , 2 , 3 , 4 , 5 ]. Due to its advantages, the C 4 D method has attracted many researchers’ attention and made considerable development since it was proposed [ 1 , 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…There are two kinds of electrode configuration patterns of C 4 D sensor, the tubular configuration and the radial configuration, as illustrated in Figure 2 [ 1 , 4 , 6 , 7 , 8 ]. The tubular configuration is the most commonly used electrode structure of C 4 D sensor.…”

Section: Introductionmentioning

confidence: 99%

“…The sensor with tubular electrodes can obtain a large and stable signal, which helps the improvement of detection performance [ 6 , 9 ]. Through decades of sustained development, C 4 D sensors have been studied by many researchers and are mostly employed for detection in capillary electrophoresis (CE) and microchip electrophoresis (MCE) (the inner diameter of the pipe is always less than 0.5 mm) [ 1 , 2 , 3 , 4 , 10 ]. In these fields, the tubular configuration can meet the measurement requirement well.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the Effects of Electrode Geometry on the Performance of C4D Sensor with Radial Configuration

Huang

Jiang

et al. 2021

Sensors

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Electrodes are basic components of C4D (capacitively coupled contactless conductivity detection) sensors, and different electrode structures (the configuration pattern or the electrode geometry) can lead to different measurement results. In this work, the effects of electrode geometry of radial configuration on the measurement performance of C4D sensors are investigated. Two geometrical parameters, the electrode length and the electrode angle, are considered. A FEM (finite element method) model based on the C4D method is developed. With the FEM model, corresponding simulation results of conductivity measurement with different electrode geometry are obtained. Meanwhile, practical experiments of conductivity measurement are also conducted. According to the simulation results and experimental results, the optimal electrode geometry of the C4D sensor with radial configuration is discussed and proposed. The recommended electrode length is 5–10 times of the pipe inner diameter and the recommended electrode angle is 120–160°.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Investigation of the Effects of Electrode Geometry on the Performance of C4D Sensor with Radial Configuration

Huang

Jiang

et al. 2021

Sensors

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“…Nonselective conductivity detection in the form of C 4 D is employed for detection of methylarginines, which exhibit only a very weak response in UV photometry at low wave lengths around 200 nm [ 46 ]. Methylarginines appear in C 4 D in BGE based on AcOH as negative peaks because the mobility of their cations is less than the mobility of the BGE co-ions, the highly mobile H 3 O + ions [ 47 ].…”

Section: Introductionmentioning

confidence: 99%

Electrophoretic Determination of Symmetric and Asymmetric Dimethylarginine in Human Blood Plasma with Whole Capillary Sample Injection

Tůma

Sommerová

Koval

et al. 2021

IJMS

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Asymmetric and symmetric dimethylarginines are toxic non-coded amino acids. They are formed by post-translational modifications and play multifunctional roles in some human diseases. Their determination in human blood plasma is performed using capillary electrophoresis with contactless conductivity detection. The separations are performed in a capillary covered with covalently bonded PAMAPTAC polymer, which generates anionic electroosmotic flow and the separation takes place in the counter-current regime. The background electrolyte is a 750 mM aqueous solution of acetic acid with pH 2.45. The plasma samples for analysis are treated by the addition of acetonitrile and injected into the capillary in a large volume, reaching 94.5% of the total volume of the capillary, and subsequently subjected to electrophoretic stacking. The attained LODs are 16 nm for ADMA and 22 nM for SDMA. The electrophoretic resolution of both isomers has a value of 5.3. The developed method is sufficiently sensitive for the determination of plasmatic levels of ADMA and SDMA. The determination does not require derivatization and the individual steps in the electrophoretic stacking are fully automated. The determined plasmatic levels for healthy individuals vary in the range 0.36–0.62 µM for ADMA and 0.32–0.70 µM for SDMA.

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Potentiality of miniaturized techniques for the analysis of drugs of abuse

et al. 2021

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Capillary electromigration (CE) and liquid chromatographic techniques (CLC/nano‐LC) are miniaturized techniques offering distinct advantages over conventional ones in the field of separation science. Among these, high efficiency, high chromatographic resolution, and use of minute volumes of both mobile phase and sample volumes are the most important. CE and CLC/nano‐LC have been applied to the analysis of many compounds including peptides, proteins, drugs, enantiomers, ions, etc. Over the years, the methods described here have also been used for the analysis of compounds of clinical, forensic, and toxicological interest. In this review article, the main features of the mentioned techniques are summarized. Their potentiality for the analysis of drugs of abuse are discussed. Some selected applications in this field in the period of 2015–present are also reported.

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Capacitively coupled contactless conductivity detection for analytical techniques – Developments from 2018 to 2020

Cited by 46 publications

References 120 publications

Investigation of the Effects of Electrode Geometry on the Performance of C4D Sensor with Radial Configuration

Investigation of the Effects of Electrode Geometry on the Performance of C4D Sensor with Radial Configuration

Electrophoretic Determination of Symmetric and Asymmetric Dimethylarginine in Human Blood Plasma with Whole Capillary Sample Injection

Potentiality of miniaturized techniques for the analysis of drugs of abuse

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