Capacitive hyperthermia as an alternative to brachytherapy in DNA damages of human prostate cancer cell line (DU-145)

Mahdavi, Seied Rabi; Esfahani, Azam Janati; Khoei, Samideh; Bakhshandeh, Mohsen; Rajabi, A. A.

doi:10.1080/09553002.2019.1532608

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…In terms of their usefulness as research tools, spheroids can mimic the in vivo tumour microenvironment more accurately than can standard cultures, supporting characteristics such as anchorage-independent growth, the presence of intra-tumoral hypoxia, acidosis, the formation of nutrient gradients and nutrient deprivation, the development of metastases and immune cell interactions. 67,75 Furthermore, spheroids can also mimic avascular tumours and micrometastases. 72 When used in the context of prostate cancer, these spheroids are called prostaspheres.…”

Section: -D Cell Culture Modelsmentioning

confidence: 99%

“…67 Mahdavi and colleagues used DU145 cell spheroids to evaluate two treatment combinations: radiofrequency-capacity hyperthermia (HT) plus teletherapy (EBRT) versus EBRT plus high-dose rate brachytherapy (BR). 75 Based on the DNA damage inflicted in the DU145 cells, they concluded that HT plus EBRT seemed to be more effective than EBRT plus BR. 75 Another example of the use of spheroids was provided by Martinez-Marin and colleagues, who used PC3 spheroids to study the molecular interactions between macrophages and prostate cancer cells and the role of pigment epithelium-derived factor (PEDF).…”

Section: -D Cell Culture Modelsmentioning

confidence: 99%

“…75 Based on the DNA damage inflicted in the DU145 cells, they concluded that HT plus EBRT seemed to be more effective than EBRT plus BR. 75 Another example of the use of spheroids was provided by Martinez-Marin and colleagues, who used PC3 spheroids to study the molecular interactions between macrophages and prostate cancer cells and the role of pigment epithelium-derived factor (PEDF). The results showed that PEDF, which is a known anti-angiogenic and anti-tumour factor, modulated the interaction between macrophages and PC3 cells through bidirectional signalling leading to tumour cell apoptosis and phagocytosis.…”

Section: -D Cell Culture Modelsmentioning

confidence: 99%

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An Overview of Current Alternative Models for Use in the Context of Prostate Cancer Research

et al. 2020

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Prostate cancer is one of the most commonly diagnosed cancers worldwide, particularly in elderly populations. To mitigate the expected increase in prostate cancer-related morbidity and mortality as a result of an expanding aged population, safer and more effective therapeutics are required. To this end, plenty of research is focusing on the mechanisms underlying cancer initiation and development, the metastatic process and on the discovery of new therapies. While animal models are used (mainly rats and mice) for the study of prostate cancer, alternative models and methods are increasingly being considered to replace, or at least reduce, the number of animals used in this particular field of research. In this review, we cover some of the alternative models that are currently available for use in the study of prostate cancer, including: mathematical models; 2-D and 3-D cell cultures; microfluidic devices; the chicken egg chorioallantoic membrane-based model; and zebrafish embryo-based models. The main advantages and limitations, as well as some examples of applications, are given for each type of model. According to our analysis, immortalised cell lines are still the most commonly used models in the field of prostate cancer research. However, the use of alternative models for prostate cancer research will likely become more prevalent in the coming years partly because of the increasing societal pressure to reduce the numbers of laboratory animals. In this context, the development and dissemination of effective non-animal alternative models assumes particular relevance and will be instrumental in leveraging their success. Taking these perspectives into account, we believe that technological advances will lead to more effective cell culture systems, namely 3-D cultures or organ-on-a-chip devices, which can be used to replace animal-based models in prostate cancer research.

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Section: -D Cell Culture Modelsmentioning

confidence: 99%

Section: -D Cell Culture Modelsmentioning

confidence: 99%

Section: -D Cell Culture Modelsmentioning

confidence: 99%

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An Overview of Current Alternative Models for Use in the Context of Prostate Cancer Research

et al. 2020

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Combined hyperthermia and radiotherapy for prostate cancer: a systematic review

Guévelou

Chirila

Achard

et al. 2022

International Journal of Hyperthermia

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Enhancing fire safety with Improved Risk Index and BIM in building evacuation

Zhang,

Jiang,

2024

ECAM

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PurposeThe purpose of this paper is to conduct a comprehensive study on building, fire and evacuation, so as to effectively improve the efficiency of building fire evacuation and the management level of fire evacuation site. Make up for the difficulties of BIM technology in effectively connecting building information and fire data.Design/methodology/approachFirst, this paper establishes a fire model and an evacuation model based on BIM information. Then, the safety index (SI) is introduced as a comprehensive index, and the IRI is established by integrating the SI function to evaluate the safety of evacuation routes. Based on these two indices, the IRI-based fire evacuation model is established.FindingsThis study offers an Improved Risk Index (IRI)-based fire evacuation model, which may achieve effective evacuation in fire scenes. And the model is verified by taking the fire evacuation of a shopping center building as an example.Originality/valueThis paper proposes a fire evacuation principle based on IRI, so that the relevant personnel can comprehensively consider the fire factors and evacuation factors to achieve the optimization of building design, thereby improving the fire safety of buildings.

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Capacitive hyperthermia as an alternative to brachytherapy in DNA damages of human prostate cancer cell line (DU-145)

Cited by 3 publications

References 17 publications

An Overview of Current Alternative Models for Use in the Context of Prostate Cancer Research

An Overview of Current Alternative Models for Use in the Context of Prostate Cancer Research

Combined hyperthermia and radiotherapy for prostate cancer: a systematic review

Enhancing fire safety with Improved Risk Index and BIM in building evacuation

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