Capacidad de la procalcitonina para predecir bacteriemia en pacientes con neumonía adquirida en la comunidad

Julián-Jiménez, Agustín; Zapata, Jesús Timón; Laserna-Mendieta, Emilio J; Miguez, Raquel Parejo; Chacartegui, Manuel Flores; Schall, Pablo Gallardo

doi:10.1016/j.medcli.2013.05.046

Cited by 23 publications

(16 citation statements)

References 26 publications

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“…Several studies pointed out that BALF culture has higher pathogen detection rate than sputum culture [16]. We also considered the anti-pathogen activities Chlamydophila pneumoniae) [22][23][24]. LDH occurs in the blood when tissues and organs are damaged, so it is used to be a biomarker to evaluate disease severity of MPP in clinic [25].…”

Section: Discussionmentioning

confidence: 99%

GM-CSF and HMGB1 level were associated with the clinical characteristics and prognosis of childhood refractory mycoplasma pneumoniae pneumonia

Cao

Lin

et al. 2020

Preprint

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Background: To analyze the relationship between granulocyte-macrophage colony-stimulating factor (GM-CSF) and high mobility group box 1 (HMGB1) level in alveolar lavage fluid with the clinical characteristics and prognosis of children refractory mycoplasma pneumoniae pneumonia (MPP), so as to provide reliable targets for clinical diagnosis and treatment. Methods: A total of 106 children diagnosed with MPP and prepared for bronchoalveolar lavage therapy were selected in this study, which were divided into 2 groups according to clinical diagnosis: those showing clinical and radiological deterioration despite appropriate antibiotic therapy for ≥7 days were classified into refractory MPP group (n=47), while the others were classified into non-refractory MPP group (n=59). The data of physical examination, treatment and outcome were collected. In addition, the GM-CSF and HMGB1 levels in alveolar lavage fluid during each bronchoalveolar lavage therapy were detected by ELISA kits. Results: There was no significant difference in age, sex, course of fever, the highest temperature, WBC, L, PLT, ALT, AST, CK-MB, D-D, CK, IgG, IgA, IgM, C3, and C4 between refractory MMP group and non-refractory MMP group on admission (P＞0.05). The levels of N, CRP, PCT, and LDH in refractory MPP group were higher than those in non-refractory MPP group, the difference had statistical significance (P＜0.05). Both GM-CSF and HMGB1 levels were positively correlated with traditional indicators N, CRP, PCT and LDH (r=0.611-0.785, P<0.05). ROC analysis results showed that CRP, GM-CSF and HMGB1 had predictive value for refractory MPP attack (AUC=0.636, 0.657, 0.651, P<0.05). Logistic regression analysis results showed GM-CSF and HMGB1 were independent factors for refractory MPP (B＞1.0, P<0.05). ROC analysis results showed that GM-CSF and HMGB1 at 2nd bronchoalveolar lavage therapy had predictive value for long hospital stay (>28 d) and poor prognosis of refractory MPP (AUC=0.782-0.825, P < 0.05). Conclusion: The level of GM-CSF and HMGB1 in alveolar lavage fluid is closely related to the occurrence and development of refractory MPP, which can be used as an auxiliary indicator for clinical diagnosis and prognosis evaluation, and has certain guiding significance for its clinical treatment.

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Section: Discussionmentioning

confidence: 99%

GM-CSF and HMGB1 level were associated with the clinical characteristics and prognosis of childhood refractory mycoplasma pneumoniae pneumonia

Cao

Lin

et al. 2020

Preprint

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“…En este escenario clínico, en la última década, se ha acentuado el estudio de los factores predictores de bacteriemia [27] y se han propuesto distintos modelos predictivos para los SU de distinta complejidad [14][15][16][28][29][30][31][32]. Cabe destacar el papel que los BMRII, y en especial la PCT, han adquirido en los últimos años como factores predictores independientes de bacteriemia [33,34], con una capacidad diagnóstica incluso mayor que la de algunos modelos [19].…”

Section: Discussionunclassified

Predictive factors of bacteraemia in the patients seen in emergency departments due to infections

Iqbal‐Mirza¹,

Estévez-González²,

Ávila³

et al. 2020

Rev Esp Quimioter

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Objectives. The aim of the study was to analyze predictive factors of bacteraemia in patients seen in the emergency department (ED) for an episode of infectious disease. Patients and methods. Observational, retrospective and descriptive analytical study of all blood cultures extracted in an ED in adult patients (≥ 18 years) seen in ED due to infectious disease from 1-1-2019 to 1-7-2019. The follow-up was carried out during 30 days. Thirty-eight variables for predicting bacteraemia were assessed. They covered epidemiological, comorbidity, functional, clinical and analytical factors. Univariate and multivariate logistic regression analysis was performed. Results. A total of 1,425 blood cultures were finally enrolled in the study. Of those were considered true bacteremia 179 (12.6 %) and as negative blood cultures 1,246 (87.4 %). Amongst negatives, 1,130 (79.3%) without growth and 116 (8.1%) as contaminants blood cultures. Five variables were significantly associated with true bacteraemia: serum procalcitonin (PCT)

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“…En nuestra experiencia durante años, tras el análisis del rendimiento de los hemocultivos indicados en nuestro SU y la búsqueda de herramientas objetivas que nos puedan ayudar a mejorar la sospecha de bacteriemia 8,9 , hemos incluido además de las variables indicadas por Cuervo et al 1 , otros datos analíticos (como el lactato y la procalcitonina) y la situación clínica del paciente con sospecha de bacteriemia (de acuerdo con los criterios clásicos de sepsis, sepsis grave y shock séptico), ya que la posibilidad de bacteriemia aumenta según lo hace la gravedad clínica 4 . De forma que, inicialmente para las neumonías y las infecciones del tracto urinario (también en nuestro entorno las dos causas más frecuentes de bacteriemia y sepsis grave) 8,9 , y posteriormente para todos los pacientes con infección, hemos adaptado a nuestro SU las recomendaciones publicadas en la revista de la Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC) 6 (Tabla 1).…”

Section: Importancia De La Predicción De Bacteriemia En Los Serviciosunclassified

“…De forma que, inicialmente para las neumonías y las infecciones del tracto urinario (también en nuestro entorno las dos causas más frecuentes de bacteriemia y sepsis grave) 8,9 , y posteriormente para todos los pacientes con infección, hemos adaptado a nuestro SU las recomendaciones publicadas en la revista de la Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC) 6 (Tabla 1). Por otro lado, en numerosos SU ya se ha implantado el "código sepsis (CS)" (iniciativa española a la que se han sumado múltiples Sociedades Científicas Internacionales, entre ellas la Sociedades Chilenas de Medicina Intensiva y la de Medicina de Urgencias y, esperamos que también pronto, la Sociedad Chilena de Infectología).…”

Section: Importancia De La Predicción De Bacteriemia En Los Serviciosunclassified

Importancia de la predicción de bacteriemia en los servicios de urgencias

Julián-Jiménez

2016

Rev. chil. infectol.

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Capacidad de la procalcitonina para predecir bacteriemia en pacientes con neumonía adquirida en la comunidad

Cited by 23 publications

References 26 publications

GM-CSF and HMGB1 level were associated with the clinical characteristics and prognosis of childhood refractory mycoplasma pneumoniae pneumonia

GM-CSF and HMGB1 level were associated with the clinical characteristics and prognosis of childhood refractory mycoplasma pneumoniae pneumonia

Predictive factors of bacteraemia in the patients seen in emergency departments due to infections

Importancia de la predicción de bacteriemia en los servicios de urgencias

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