Capabilities of perfusion ASPECTS in predicting the efficiency of intravenous thrombolytic therapy

Кулеш, А. А.; Дробаха, В. Е.; Кайлева, Н. А.; Syromyatnikova, L. I.; Golosova, Yu. A.; Shestakov, V. V.

doi:10.14412/2074-2711-2017-3-10-17

Cited by 4 publications

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References 11 publications

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“…Äàííûé ôàêò ìîaeåò ñâèäåòåëüñòâîâàòü êàê î ðîëè êîìïåíñàòîðíûõ âîçìîaeíîñòåé ìîçãîâîé öèðêóëÿöèè â ìîäóëÿöèè èììóííîãî îòâåòà íà èíôàðêò ìîçãà ïðè öåðåáðàëüíîé ðåïåðôóçèè, òàê è î çíà÷èìîñòè èøåìè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ (÷åì áîëüøå ñòåíîç, òåì âûøå êîíöåíòðàöèÿ ïðîòèâîâîñïàëèòåëüíîãî öèòîêèíà). Ïîëó÷åííûå äàííûå ñîîòíîñÿòñÿ ñ ðåçóëüòàòàìè íàøåãî ïðåäûäóùåãî èññëåäîâàíèÿ, êîòîðîå ïîêàçàëî, ÷òî ðàçìåð ïåíóìáðû, ïî äàííûì ÊÒ-ïåðôóçèè, ó êàíäèäàòîâ íà ÒËÒ àññîöèèðîâàí ñî ñòåïåíüþ ñòåíîçèðîâàíèÿ, ïðîòèâîïîëîaeíîé î÷àãó ñîííîé àðòåðèè [11]. Â ïîäãðóïïå áåç ÒËÒ çàôèêñèðîâàíû êîððåëÿöèè ìåaeäó óðîâíåì öèòîêèíîâ, êîíöåíòðàöèåé êðåàòèíèíà, òðèãëèöåðèäîâ, ëèïîïðîòåèíîâ î÷åíü íèçêîé ïëîòíîñòè, Ñ-ðåàêòèâíîãî áåëêà, êîíå÷íûì ñèñòîëè÷åñêèì, äèàñòîëè÷åñêèì ðàçìåðîì è òîëùèíîé çàäíåé ñòåíêè ëåâîãî aeåëóäî÷êà.…”

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Interrelation of the dynamics of serum concentrations of interleukin-1β, interleukin-6 and interleukin-10 with clinical data in acute ischemic stroke and the strategy of reperfusion therapy

et al. 2020

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Aim. To study the relationship between the dynamics of serum concentrations of interleukin-1β, interleukin-6 and interleukin-10 with clinical data in the acute period of ischemic stroke, and the strategy of reperfusion therapy.Materials and methods. In 28 patients with acute ischemic stroke, half of whom underwent intravenous thrombolysis, the concentration of interleukin-1β, interleukin-6 and interleukin-10 was assessed at admission, on the 3rd and 10th day of the disease.Results. The concentration of interleukin-1β and interleukin-6 decreases during the acute period of stroke. The concentration of interleukin-10 remains unchanged for the first 10 days since the development of stroke. When thrombolysis is performed, there is a more significant decrease in interleukin-1β concentration in the hyperacute period of stroke, whereas in patients without reperfusion there is a decrease in interleukin-6 concentration from 1 to 10 days. The concentration of cytokines is associated with age, lipid spectrum, severity of carotid atherosclerosis, myocardial hypertrophy and injection fraction of the heart. Only in the subgroup of thrombolysis, correlations of cytokine concentrations with systolic blood pressure at admission, hemoglobin concentration, total cholesterol and high-density lipoproteins, hematocrit, degree of stenosis of the contralateral carotid artery, injection fraction and the number of antihypertensive drugs prescribed in the hospital were recorded. The concentration of interleukin-6 at day 10 is associated with the severity of stroke at admission, and the level of IL-10 on day 3 of the disease, with the mobility of patients at discharge.Conclusions. In the hyperacute period of stroke, there is a decrease in the pro-inflammatory activity of blood serum, more pronounced in patients undergoing systemic thrombolysis. Concentrations of interleukin1β, interleukin-6 and interleukin-10 are associated with a wide range of parameters characterizing the cardiovascular and functional status, and the pattern of these associations differs depending on the reperfusion therapy strategy.

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Section: Discussionunclassified

Interrelation of the dynamics of serum concentrations of interleukin-1β, interleukin-6 and interleukin-10 with clinical data in acute ischemic stroke and the strategy of reperfusion therapy

et al. 2020

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“…[20,21]. Большое внимание в настоящий момент уделяется контрастным методикам, таким как КТперфузия и КТ-ангиография, особенно при решении вопроса об использовании реперфузионных технологий в лечении ИИ [22,23]. При этом разработаны системы автоматического анализа полученных изображений [24,25].…”

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Computed tomography-based mathematical modeling of ischemic stroke outcomes based on the focus characteristics

Ершов

Chirkov

Gumalatova

et al. 2021

RJTAO

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Objective: to identify the prognostic aspects of the ischemic stroke (IS) focus characteristics according to the data of computed tomography of the brain.Patients and methods. We examined 80 patients with hemispheric IS up to 1-day old (50 patients for constructing mathematical models of disease outcomes and 30 patients for subsequent testing of the obtained models) aged 30-84 years.Results and discussion. The analysis of the association between mortality probability and brain midline shift size shown that a brain midline shift of 4.5-5 mm did not increase mortality probability much, which indicates the synergistic stability of this system. System destabilization began after an increase of the brain midline shift for more than 5-5.5 mm. After a mild change in the initial indicator (6-8 mm), mortality probability increased from 25% to 90% and higher. When the brain midline shift was more than 8.5 mm, the system, from the synergistic viewpoint, became stable again but with an unfavorable prognosis. This analysis helps to identify the critical decision-making point when analyzing the IS focus neuroimaging characteristics. Thus, the point for the focus volume is 145 cm3, and for the brain midline shift - 5.0 mm.Conclusion. The results of our study about the prognostic value of the IS focus characteristics according to CT data may have additional value for decision-making in the management of patients with a poor prognosis.

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Experience of using a Russian alteplase product as thrombolytic therapy in patients with ischemic stroke in routine practice

Murtazalieva,

Zakaryaeva,

Soshina

et al. 2023

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Capabilities of perfusion ASPECTS in predicting the efficiency of intravenous thrombolytic therapy

Cited by 4 publications

References 11 publications

Interrelation of the dynamics of serum concentrations of interleukin-1β, interleukin-6 and interleukin-10 with clinical data in acute ischemic stroke and the strategy of reperfusion therapy

Interrelation of the dynamics of serum concentrations of interleukin-1β, interleukin-6 and interleukin-10 with clinical data in acute ischemic stroke and the strategy of reperfusion therapy

Computed tomography-based mathematical modeling of ischemic stroke outcomes based on the focus characteristics

Experience of using a Russian alteplase product as thrombolytic therapy in patients with ischemic stroke in routine practice

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