Capabilities of laser ablation inductively coupled plasma time-of-flight mass spectrometry

Burger, Marcel; Schwarz, Gunnar; Gundlach‐Graham, Alexander; Käser, Debora; Hattendorf, Bodo; Günther, Detlef

doi:10.1039/c7ja00236j

Cited by 46 publications

(49 citation statements)

References 60 publications

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“…, Burger et al . ) report 100%‐mass‐normalised quantification across a heterogeneous material. Mass quantification by 100% normalisation is particularly well‐suited for ToF‐MS because complete‐element detection ensures all measurable elements are accounted for in the normalisation calculation (Leach and Hieftje ).…”

Section: Resultsmentioning

confidence: 99%

“…, Burger et al . ) and promote low‐dispersion aerosol transport to facilitate optimum pulse‐to‐pulse separation of ablated signals and thus improve lateral resolution. However, it should be mentioned that, because low‐dispersion aerosol transport preserves high instantaneous concentration of ablated aerosols into the plasma, it could be difficult to measure of high‐mass matrix elements for which ToF‐MS has higher sensitivity.…”

Section: Methodsmentioning

confidence: 99%

“…Detailed evaluation on the impact of baseline subtraction on abundance sensitivity performance and accuracy of quantification for LA‐ICP‐ToF‐MS can be found elsewhere (Burger et al . , Hendriks et al . ).…”

Section: Methodsmentioning

confidence: 99%

“…As reported in Table S1, low-dispersion aerosol transport with the tube cell required fairly high gas flow rates into the injector (1.7 l min -1 He, 0.84 l min -1 Ar). These gas flow rates are typical of our low-dispersion LA system , Burger et al 2017 and promote lowdispersion aerosol transport to facilitate optimum pulse-topulse separation of ablated signals and thus improve lateral resolution. However, it should be mentioned that, because low-dispersion aerosol transport preserves high instantaneous concentration of ablated aerosols into the plasma, it could be difficult to measure of high-mass matrix elements for which ToF-MS has higher sensitivity.…”

Section: La-icp-tof-ms Imagingmentioning

confidence: 99%

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High‐resolution, Quantitative Element Imaging of an Upper Crust, Low‐angle Cataclasite (Zuccale Fault, Northern Apennines) by Laser Ablation ICP Time‐of‐Flight Mass Spectrometry

Gundlach‐Graham

Garofalo

Schwarz

et al. 2018

Geostandard Geoanalytic Res

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Laser ablation inductively coupled plasma time‐of‐flight mass spectrometry (LA‐ICP‐ToF‐MS) was used to generate quantitative elemental images of a mineralogically and texturally complex fault rock of the Northern Apennines of Italy (Zuccale Fault, eastern Island of Elba). Using LA‐ICP‐ToF‐MS combined with a low‐dispersion LA cell, we were able to generate large format (4 mm × 2 mm), high‐resolution (5 μm), high dynamic range (1–106 μg g−1) and quantitative multi‐elemental two‐dimensional compositional maps within a data acquisition time of a few hours. To quantify element mass fractions across the heterogeneous sample of the Zuccale Fault, we used a 100% species‐mass normalisation approach that took into account different mineral phases across the specimen. To assign mineral phase directly from LA‐ICP‐ToF‐MS data, we exploited the segregation of sulfur and calcium between distinct phases to threshold element images and develop mineral‐phase‐specific masks. Moreover, we demonstrate agreement between elemental mass fractions determined by LA‐ICP‐ToF‐MS imaging with 100% normalisation quantification and conventional LA‐ICP‐MS analysis with internal standard element‐based quantification. Finally, we discuss how this elemental imaging provides unique insights into the genesis of the Zuccale Fault.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: La-icp-tof-ms Imagingmentioning

confidence: 99%

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High‐resolution, Quantitative Element Imaging of an Upper Crust, Low‐angle Cataclasite (Zuccale Fault, Northern Apennines) by Laser Ablation ICP Time‐of‐Flight Mass Spectrometry

Gundlach‐Graham

Garofalo

Schwarz

et al. 2018

Geostandard Geoanalytic Res

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“…Burger et al . () characterised the icp TOF in combination with 193 nm laser ablation sampling. With a conventional high‐dispersion LA cell, element mass fractions in NIST SRM 612 and USGS BCR‐2G were quantified within the uncertainty range of the preferred values when NIST SRM 610 was used as the ‘external’ RM.…”

Section: Advances In Plasma Source Mass Spectrometry and Laser Ablatimentioning

confidence: 99%

GGR Biennial Critical Review: Analytical Developments Since 2014

Linge

Bèdard

Bugoi

et al. 2017

Geostandard Geoanalytic Res

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This GGR biennial critical review covers developments and innovations in key analytical methods published since January 2014, relevant to the chemical, isotopic and crystallographic characterisation of geological and environmental materials. In nine selected analytical fields, publications considered to be of wide significance are summarised, background information is provided and their importance evaluated. In addition to instrumental technologies, this review also presents a summary of new developments in the preparation and characterisation of rock, microanalytical and isotopic reference materials, including a précis of recent changes and revisions to ISO guidelines for reference material characterisation and reporting. Selected reports are provided of isotope ratio analyses by both solution-nebulisation MC-ICP-MS and laser ablation-ICP-MS, as well as of radioactive isotope geochronology by LA-ICP-MS. Most of the analytical techniques elaborated continue to provide new applications for geochemical analysis, however it is noted that instrumental neutron activation analysis has become less popular in recent years, mostly due to the reduced availability of nuclear reactors to act as a neutron source. Many of the newer applications reported here provide analysis at increasingly finer resolution. Examples include atom probe tomography, a very sensitive method providing atomic scale information, nanoscale SIMS, for isotopic imaging of geological and biological samples, and micro-XRF, which has a spatial resolution many orders of magnitude smaller than conventional XRF

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Skip the beat: minimizing aliasing error in LA-ICP-MS measurements

Hattendorf¹,

Hartfelder

Günther³

2018

Anal Bioanal Chem

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Pulsed laser ablation sampling and sequential isotope detection can lead to signal beat in the registered signal intensities. In particular, if aerosol transport systems deliver ablated aerosol with temporal duration close to that of a single mass scan, such signal beat can become significant and lead to biased intensity ratios and concentrations. Averaging signal intensities based on the least common multiple of scan duration and laser pulse period can eliminate such a systematic bias and improve the accuracy of quantitative laser ablation experiments. The method was investigated for experiments using an ablation cell that provided aerosol washout times near 200 ms and quadrupole-based ICP-MS acquisition using different dwell and settling times that were compared with and extended by numerical simulations. It was found that the systematic bias of acquired data could exceed the inherent noise of laser ablation inductively couple plasma mass spectrometry experiments and that the averaging method could successfully minimize the bias due to beating. However, simulations revealed that this was only the case for combinations of pulse frequency and scan duration in which the number of laser pulses within the averaged period was an integer multiple of the number of isotopes in the acquisition method. In element imaging applications, this averaging will necessarily increase the size of individual pixels and it depends not only on the laser beam size but also pulse repetition rate and the acquisition settings for a sequential mass spectrometer. Graphical abstract LCM averaging can prevent occurrence of a systematic bias in LA-ICPMS measurements.

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Capabilities of laser ablation inductively coupled plasma time-of-flight mass spectrometry

Abstract: Evaluation of capabilities offered by ICP-TOFMS for various laser-ablation-based sample introduction schemes.

Cited by 46 publications

References 60 publications

High‐resolution, Quantitative Element Imaging of an Upper Crust, Low‐angle Cataclasite (Zuccale Fault, Northern Apennines) by Laser Ablation ICP Time‐of‐Flight Mass Spectrometry

High‐resolution, Quantitative Element Imaging of an Upper Crust, Low‐angle Cataclasite (Zuccale Fault, Northern Apennines) by Laser Ablation ICP Time‐of‐Flight Mass Spectrometry

GGR Biennial Critical Review: Analytical Developments Since 2014

Skip the beat: minimizing aliasing error in LA-ICP-MS measurements

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