Capabilities and Limitations of Speckle Tracking Stress Echocardiography

Степанова, А. И.; Alekhin, M N

doi:10.29001/2073-8552-2019-34-1-10-17

Cited by 3 publications

(2 citation statements)

References 48 publications

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“…Чем выше был у участников исследования уровень гликемии, HbA 1с и тяжести ИР, тем более выраженными оказались у них нарушения ДФ. В отличие от стандартного объем-зависимого определения ФВ ЛЖ новая методика спекл-трекинга дает возможность получить более целостное представление о механике сокращения и расслабления различных участков сердца [14]. Она представляется более точной в современную эпоху прецизионной медицины, а также особенно востребованной, учитывая, что нынешнее время отмечено преобладанием ХСНсФВ, при которой ФВ не имеет прогностического значения [7].…”

Section: Discussionunclassified

Significance of standard and speckle-tracking echocardiography for early diagnosis of asymptomatic left ventricular dysfunction in type 2 diabetes

Utina¹,

Акашева²,

Korsunsky³

et al. 2023

Cardiovasc Ther Prev

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Aim. To study the relationship between echocardiographic parameters of left ventricular (LV) function and carbohydrate metabolism indicators, as well as to evaluate value of speckle-tracking echocardiography (STE) in the early diagnosis of subclinical LV dysfunction in type 2 diabetes (T2D) in individuals without clinical manifestations of cardiovascular disease (CVD).Material and methods. The study included 120 people of both sexes aged 45 to 75 years. Patients were divided into three following groups: 1 — with T2D (n=53), 2 — with prediabetes (n=20), 3 — control, without carbohydrate metabolism disorders (n=47). All participants underwent transthoracic two-dimensional echocardiography with an assessment of standard systolic and diastolic parameters, as well as quantitative STE indicators. In addition, all participants underwent laboratory diagnostics of carbohydrate metabolism disorders, which included the determination of blood fasting glucose, glycated hemoglobin (HbA1c), insulin, and C-peptide, as well as insulin resistance index estimation.Results. In patients with T2D, in comparison with the control group, diastolic function parameters were significantly different as follows: a lower value of early to late diastolic transmitral flow velocity (E/A) ratio, the ratio of early transmitral flow velocity to early diastolic mitral annulus velocity (E/e'), mitral annular velocity (e') and higher isovolumic relaxation time (IVRT), as well as early diastolic flow deceleration time (DT). According to multivariate analysis, not only T2D, but also prediabetes was an independent predictor of diastolic dysfunction. The Simpson's LV ejection fraction was preserved in all study participants. In patients with T2D, in comparison with the control, according to STE, a decrease in global longitudinal strain (GLS), an increase in apical rotation, and also LV twist were revealed. In a multivariate regression analysis, the HbA1c level had an inverse relationship with GLS and was an independent predictor of its decrease, and the T2D duration was a significant predictor of twisting changes, apical and basal rotation. At the same time, GLS and LV twist had a high sensitivity in determining the decrease in E/A, e'/a', e', as well as the increase in IVRT.Conclusion. In patients with T2D without CVD manifestations, sub-clinical signs of diastolic dysfunction were revealed, such as delayed LV relaxation; systolic dysfunction with preserved ejection fraction was manifested by a decrease in GLS, as well as an increase in apical rotation and LV twisting, identified by STE. The severity of asymptomatic LV systolic-diastolic dysfunction was associated with the severity of glucose metabolism disorders and T2D duration.

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Section: Discussionunclassified

Significance of standard and speckle-tracking echocardiography for early diagnosis of asymptomatic left ventricular dysfunction in type 2 diabetes

Utina¹,

Акашева²,

Korsunsky³

et al. 2023

Cardiovasc Ther Prev

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show abstract

“…Несмотря на наличие ряда ограничений (избыточная масса тела или ожирение, нарушения ритма сердца, индивидуальные особенности строения грудной клетки, а именно узкие межреберные промежутки и т.д. ), применение технологии Speckle-tracking считается одной из наиболее перспективных среди иных визуализирующих методик [5][6][7].…”

Section: Fibrosis Biomarkers and Global Myocardial Strain In The Diagnosis And Prediction Of Diastolic Dysfunction In Patients With Myocaunclassified

Fibrosis biomarkers and global myocardial strain in the diagnosis and prediction of diastolic dysfunction in patients with myocardial infarction and preserved ejection fraction

et al. 2021

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Aim. To assess the correlation of fibrosis biomarkers with parameters of diastolic function (DF) in assessing global longitudinal strain in patients with ST-segment elevation myocardial infarction (STEMI) and preserved left ventricular ejection fraction (EF).Material and methods. We examined 50 patients (100%) with primary STEMI and preserved LVEF at the end of hospitalization. On the 1st day of MI, standard diagnostic investigations were carried out. On the 12th day, the serum concentration of procollagen type I carboxy-terminal propeptide (PICP), N-terminal propeptide of procollagen type III (PIIINP), and galectin-3 was determined, as well as echocardiography was performed to assess left ventricular DF. After 1 year, all participants underwent reassessment of PICP, PIIINP, and galectin-3 serum levels. Echocardiography was also performed with an assessment of DF and LV global longitudinal strain.Results. According to speckle-tracking echocardiography, LV global longitudinal strain was visualized in 30 patients (60%), who were included in the final analysis. In the rest of the patients (40%), the limitations did not allow the technique to be performed. During the hospitalization, signs of diastolic dysfunction (DD) were detected in 5 (16,6%) patients; after 1 year, their number increased by 7 (23,3%). During the 1-year follow-up, the total number of patients with echocardiographic signs of DD was 20 (67%). At the same time, global strain parameters indicated the presence of DD in 23 (77%) patients. However, comparison of the incidence of DD according to echocardiography and using the speckle-tracking technology did not show significant differences (p=0,283). Throughout the entire follow-up period, the concentration of the studied fibrosis markers significantly exceeded the control group values. We recorded associations of global strain parameters with biochemical markers of fibrosis and LV DF indicators.Conclusion. Fibrosis biomarkers (PICP, PIIINP, galectin-3), assessed in the subacute period of MI in patients with preserved EF, correlated with indicators of global myocardial strain, which indicates the potential value of their determination for predicting and detecting DD in the postinfarction period.

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Systolic function of the left and right ventricles and myocardial strain in young adults with metabolic syndrome

Bartosh-Zelenaya,

Stepanova,

Pavlova

et al. 2023

Medicinskij alfavit

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The purpose of this article is to evaluate the systolic function of the left and right ventricles and measure myocardial Strain in young people (from 18 to 44 years old) with a newly established clinical and laboratory diagnosis of metabolic syndrome (MS) according to the criteria of the International Diabetes Federation (IDF), to identify possible early markers of myocardial dysfunction. All patients underwent standard transthoracic echocardiography (EchoCG) with assessment of systolic function of the left and right ventricles (LV and RV). The work detects early markers of ventricular myocardial dysfunction using speckle tracking 2D and 4D EchoCG, and also investigates the relationship between the main components of MS and echocardiographic parameters. With the help of a comparative analysis, statistical data were revealed on the low global longitudinal strain of the left and right ventricle in 2D and 4D in the main group compared with the control group. In individuals with MS, the mean values of global circular strain (GCS), radial (GRS) strain and global area strain (GAS) of the left ventricle were also significantly lower than the control group. Indicators obesity diseases (body weight and waist circumference) had a negative correlation with the ejection fraction (EF) and parameters of ventricular strain.

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Capabilities and Limitations of Speckle Tracking Stress Echocardiography

Cited by 3 publications

References 48 publications

Significance of standard and speckle-tracking echocardiography for early diagnosis of asymptomatic left ventricular dysfunction in type 2 diabetes

Significance of standard and speckle-tracking echocardiography for early diagnosis of asymptomatic left ventricular dysfunction in type 2 diabetes

Fibrosis biomarkers and global myocardial strain in the diagnosis and prediction of diastolic dysfunction in patients with myocardial infarction and preserved ejection fraction

Systolic function of the left and right ventricles and myocardial strain in young adults with metabolic syndrome

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