Cap polyposis and colitis cystica profunda: a rare association

Abstract

diagnosis in 16-27% of cases, resulting in one in five patients being given a histopathological grade different from the consensus (gold) standard. This problem may be alleviated by having multiple pathologists assess difficult cases, which can easily be done using WSI. The results of the present study show that alternative WSI-based assessment of laryngeal premalignancies will not compromise diagnostic accuracy. 1. van der Post RS, van der Laak JAWM, Sturm B et al. The evaluation of colon biopsies using virtual microscopy is reliable.Sir: Cap polyposis and colitis cystica profunda (CCP) are two rare, benign and distinct colorectal conditions whose aetiology remains unclear. A rare association between cap polyposis and CCP has already been described; in those cases, cystic glands were present in the submucosal layer of the cap polyps. 1,2 Interestingly, in the present case, lesions of CCP were not intermingled with cap polyps, but were distant from them.A 49-year-old man with chronic colitis located in the left colon and rectum, diagnosed as ulcerative colitis 5 years previously, was referred to our institution for persistent mucous bloody stools refractory to immunosuppressive therapies (infliximab). Prior colonoscopy revealed the presence of~50 sessile reddish polyps, mainly located in the rectosigmoid area. Biopsy specimens of the polyps showed superficial erosion with elongated hyperplastic glands and a mixed inflammatory infiltrate in the lamina propria. There was no atypia or dyplasia. Biopsy specimens of the intervening mucosa were not available. Laboratory values, including complete blood count, electrolytes, and serum protein, were within normal limits. Stool culture, ova and parasite examination and PCR for Clostridium difficile toxin B and cytomegalovirus were all negative. Despite the intake of infliximab, abdominal symptoms persisted, and the patient underwent a total proctocolectomy with anal preservation and end-ileostomy.

Clinical, endoscopic, pathological characteristics and management of cap polyposis: experience from a Tertiary Hospital in China

“…We also summarized the literature on this issue ( Arana et al, 2014 ; Suzuki et al, 2014 ; Kim et al, 2017 ; Murata et al, 2017 ; Anuchapreeda et al, 2018 ; Batra et al, 2018 ; Okamoto et al, 2018 ; Tamura et al, 2018 ; Brunner et al, 2019 ; Monsalve et al, 2020 ), and evaluated the percentage of clinical improvement associated with these treatments ( Table 2 ).…”

“…Based on the literature review ( Arana et al, 2014 ; Suzuki et al, 2014 ; Bordeianou et al, 2017 ; Kim et al, 2017 ; Murata et al, 2017 ; Anuchapreeda et al, 2018 ; Batra et al, 2018 ; Okamoto et al, 2018 ; Tamura et al, 2018 ; Brunner et al, 2019 ; Monsalve et al, 2020 ) and our own data, we hypothesized that, if the patient was H. pylori positive, then H. pylori eradication combined with other therapies might be useful. There were 7 patients who were tested to have H. pylori infection; 5 of them improved after H. pylori eradication, the other two were lost to follow-up.…”

Clinical, Endoscopic, Pathological Characteristics and Managements of Cap Polyposis: A Real-world Study from China

“…Based on the literature review [2,6,7,9,[14][15][16][17][18][19]26] and our own data, we thought that, if the patient was H. pylori positive, then H. pylori eradication combined with other therapies might be useful. There were 7 patients who were tested to have H. pylori, 5 of them had improvement after H. pylori eradication, the other two was lost.…”

“…We also summarized the literature on this issue [2,6,7,9,[14][15][16][17][18][19] , and evaluated the percentage of clinical improvement of these treatments (Table 2).…”

Colitis Cystica Profunda with Gastrointestinal Stromal Tumor: A Case Report

“…What's more, CCP was associated with several diseases, such as UC, IBD, radioactive enteritis, infectious colitis, colorectal ploypoid, and even colonic adenocarcinoma or GIST [4,5] . The etiology of CCP is still unknown and may be related to congenital, in ammatory reaction or trauma [6,7] . The isolated colonic ulcer in colonoscopy may be presented as polypoid mass slightly protruding from the enteric cavity, which is similar to intestinal cancer but rarely induces obstruction [1] .…”