Cantilever Array Sensors for Bioanalysis and Diagnostics

Lang, Hans Peter; Hegner, Martin; Gerber, Christoph

doi:10.1002/9783527610389.ch10

Cited by 7 publications

(11 citation statements)

References 83 publications

(113 reference statements)

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“…These devices have ultrasensitive sensing systems to precisely perceive the changes in biological signals in a cellular microenvironment. Surface plasmon resonance (SPR) [ 6 ], nanotubes, nanowires [ 7 , 8 ], or nanocantilevers [ 9 ] are used for this purpose to quantify very low levels of biomolecules including specific DNA moieties. Quantum dots are another group of innovations which are highly fluorescent semiconductor nanocrystals and use the principle of fluorescence resonance energy transfer (FRET) for signal transduction [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Biosensors in Health Care: The Milestones Achieved in Their Development towards Lab-on-Chip-Analysis

Patel

Nanda

Sahoo

et al. 2016

Biochemistry Research International

136

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Immense potentiality of biosensors in medical diagnostics has driven scientists in evolution of biosensor technologies and innovating newer tools in time. The cornerstone of the popularity of biosensors in sensing wide range of biomolecules in medical diagnostics is due to their simplicity in operation, higher sensitivity, ability to perform multiplex analysis, and capability to be integrated with different function by the same chip. There remains a huge challenge to meet the demands of performance and yield to its simplicity and affordability. Ultimate goal stands for providing point-of-care testing facility to the remote areas worldwide, particularly the developing countries. It entails continuous development in technology towards multiplexing ability, fabrication, and miniaturization of biosensor devices so that they can provide lab-on-chip-analysis systems to the community.

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Section: Introductionmentioning

confidence: 99%

Biosensors in Health Care: The Milestones Achieved in Their Development towards Lab-on-Chip-Analysis

Patel

Nanda

Sahoo

et al. 2016

Biochemistry Research International

136

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“…Surface plasmon resonance (SPR) (49), nanowire (50), nanotube (51,52), and nanocantilever (53,54) biomolecular sensors are all classified as label-free measurement technologies, meaning that the binding of the target biomolecule to its surface-bound capture agent is directly detected. Furthermore, under flowing sample conditions, k on , k off , and/or analyte concentration (see Equations 1 and 2) can be directly measured (55,56) from the dynamic sensing response.…”

Section: Label-free Measurement Techniquesmentioning

confidence: 99%

◾ Nanotechnology and Cancer

Mendelson¹

2013

Learning Bio-Micro-Nanotechnology

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The biological picture of cancer is rapidly advancing from disease models built from phenomenological descriptions to network models derived from systems biology, which can capture the evolving pathophysiology of the disease at the molecular level. The translation of this (still academic) picture into a clinically relevant framework can be enabling for the war on cancer, but it is a scientific and technological challenge. In this review, we discuss emerging in vitro diagnostic technologies and therapeutic approaches that are being developed to handle this challenge. Our discussion of in vitro diagnostics is guided by the theme of making large numbers of measurements accurately, sensitively, and at very low cost. We discuss diagnostic approaches based on microfluidics and nanotechnology. We then review the current state of the art of nanoparticle-based therapeutics that have reached the clinic. Our goal is to identify nanotherapeutic strategies that are designed to increase efficacy while simultaneously minimizing the toxic side effects commonly associated with cancer chemotherapies. Keywords in vitro diagnostics; cancer therapeutics; nanoparticles; quantum dots; nanowires; microfluidics Recent advances, both conceptual and technological, are making it possible to imagine a future in which cancer is a manageable chronic ailment. Consider how cancer was viewed

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“…Microcantilever based sensing system is one of the promising technologies available in micro/nanotechnology for ultra-high sensitive, real-time and label-free detection. [1][2][3][4][5][6][7][8][9][10][11][12] The sensing principle in such systems is based on bending or change in resonance frequency of cantilever due to change in surface stress because of adsorption of molecules. There are some challenges while using these microcantilevers for sensing biomolecules in liquid samples.…”

mentioning

confidence: 99%

“…Problems like effect of variations in pH, ionic and temperature of liquid samples and effect of hydrodynamic forces on cantilevers making them vibrate or dampen, which in turn provide some unwanted sensing signals. 1,2,8,13,14 Also, the method of sensing layer formation on the cantilever surface affects the sensing signals obtained from cantilever measurements. 1,2,8,13,14 By taking differential detection signals between reference and sensor cantilevers, one can eliminate such problems.…”

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confidence: 99%

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Challenges and Opportunities for Capillary Based Biofunctionalization of Microcantilever Arrays

Gunda

Mitra

2014

J. Electrochem. Soc.

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Microcantilever as sensing platform has been proven to be extremely sensitive for investigating various biochemical events. Despite of its rapid and label-free detection, obtaining molecular finger print for simultaneous detection of biomarkers is limited due to the difficulty in simultaneous functionalization of cantilevers. Though capillary based functionalization has been considered as one of the best method for simultaneous functionalization, it is limited by alignment of different sized capillary arrays. In the present work, we demonstrated the challenges and opportunities available for capillary based functionalization of microcantilever arrays and address the challenges by proposing an innovative capillary functionalization using on-chip V-grooves connected to flexible capillaries. Cantilever array chip comprising 8 cantilevers spaced at 250 μm distance is simultaneously functionalized with different biomolecules by inserting into dimensional-matched V-groove arrays. We demonstrated that a simple on-chip V-groove capillary functionalization is an easy, effective and highly repeatable by performing a standard sandwich immunoassay for detecting various cardiac markers such as myoglobin and troponin T.

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Cantilever Array Sensors for Bioanalysis and Diagnostics

Cited by 7 publications

References 83 publications

Biosensors in Health Care: The Milestones Achieved in Their Development towards Lab-on-Chip-Analysis

Biosensors in Health Care: The Milestones Achieved in Their Development towards Lab-on-Chip-Analysis

◾ Nanotechnology and Cancer

Challenges and Opportunities for Capillary Based Biofunctionalization of Microcantilever Arrays

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