Cantharis by photosynthetic bacteria biotransformation: Reduced toxicity and improved antitumor efficacy

Yu, Man Shan; Zhao, Yue

doi:10.1016/j.jep.2016.03.058

Cited by 7 publications

(9 citation statements)

References 11 publications

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“…Despite antitumor activities, cantharidin may have other biological activities, such as stimulation of bone marrow or sexual arousal (Ghoneim, 2013; Torbeck et al, 2014). However, the biggest problem with the medical usage of cantharidin is the toxicity of this compound to the mucosa, mainly the ureter, kidney and gastrointestinal tract (Yu and Zhao, 2016). However, the studies conducted by Yu and Zhao (2016) showed a very interesting perspective.…”

Section: Source Of Bioactive Agentsmentioning

confidence: 99%

Beetles as Model Organisms in Physiological, Biomedical and Environmental Studies – A Review

et al. 2019

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Model organisms are often used in biological, medical and environmental research. Among insects, Drosophila melanogaster, Galleria mellonella, Apis mellifera, Bombyx mori, Periplaneta americana , and Locusta migratoria are often used. However, new model organisms still appear. In recent years, an increasing number of insect species has been suggested as model organisms in life sciences research due to their worldwide distribution and environmental significance, the possibility of extrapolating research studies to vertebrates and the relatively low cost of rearing. Beetles are the largest insect order, with their representative – Tribolium castaneum – being the first species with a completely sequenced genome, and seem to be emerging as new potential candidates for model organisms in various studies. Apart from T. castaneum , additional species representing various Coleoptera families, such as Nicrophorus vespilloides, Leptinotarsa decemlineata, Coccinella septempunctata, Poecilus cupreus, Tenebrio molitor and many others, have been used. They are increasingly often included in two major research aspects: biomedical and environmental studies. Biomedical studies focus mainly on unraveling mechanisms of basic life processes, such as feeding, neurotransmission or activity of the immune system, as well as on elucidating the mechanism of different diseases (neurodegenerative, cardiovascular, metabolic, or immunological) using beetles as models. Furthermore, pharmacological bioassays for testing novel biologically active substances in beetles have also been developed. It should be emphasized that beetles are a source of compounds with potential antimicrobial and anticancer activity. Environmental-based studies focus mainly on the development and testing of new potential pesticides of both chemical and natural origin. Additionally, beetles are used as food or for their valuable supplements. Different beetle families are also used as bioindicators. Another important research area using beetles as models is behavioral ecology studies, for instance, parental care. In this paper, we review the current knowledge regarding beetles as model organisms and their practical application in various fields of life science.

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Section: Source Of Bioactive Agentsmentioning

confidence: 99%

Beetles as Model Organisms in Physiological, Biomedical and Environmental Studies – A Review

et al. 2019

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“…However, this compound also has significant toxicity in mammals related to its anticancer activity (Deng et al, 2013; Puerto Galvis et al, 2013; Ratcliffe et al, 2014). Extensive studies have been undertaken to reduce this toxicity through modification of the compound (Deng et al, 2013; Puerto Galvis et al, 2013), alternative production and delivery methods (Chang et al, 2008; Han et al, 2013; Yu and Zhao, 2016), or combination therapies (Wu et al, 2015). These efforts highlight that the resolution of issues, such as toxicity, will require the investment of time and money into basic scientific research for the development process.…”

Section: Development Of Bioactive Molecules Into Therapeuticsmentioning

confidence: 99%

Tick Bioactive Molecules as Novel Therapeutics: Beyond Vaccine Targets

Murfin

Fikrig

2017

Front. Cell. Infect. Microbiol.

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“…A few studies have reported that some TCMs attenuate the adverse effects of chemotherapy or radiotherapy and produce fewer or no adverse reactions, but other studies have suggested that TCMs may cause obvious adverse reactions (65)(66)(67). Kansui, the root of Euphorbia kansui T.N.…”

Section: Adverse Reactionsmentioning

confidence: 99%

Advance in studies on traditional Chinese medicines to treat infection with the hepatitis B virus and hepatitis C virus

Xia

Inagaki

Song

et al. 2016

BST

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Cantharis by photosynthetic bacteria biotransformation: Reduced toxicity and improved antitumor efficacy

Cited by 7 publications

References 11 publications

Beetles as Model Organisms in Physiological, Biomedical and Environmental Studies – A Review

Beetles as Model Organisms in Physiological, Biomedical and Environmental Studies – A Review

Tick Bioactive Molecules as Novel Therapeutics: Beyond Vaccine Targets

Advance in studies on traditional Chinese medicines to treat infection with the hepatitis B virus and hepatitis C virus

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