Cantharidin Treatment of Molluscum Contagiosum

Funt, Tobias R.

doi:10.1001/archderm.1961.01580090154021

Cited by 21 publications

(16 citation statements)

References 2 publications

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“…Clinical data detailing localized, linear or a mirror image or “kissing lesion” distribution and morphology, as well as negative immunofluorescence studies, help to clarify the diagnosis. Additionally, cantharidin has been used for many conditions by both folk and traditional medicine, being employed frequently in the treatment of verruca vulgaris and molluscum contagiosum . Biopsy of a lesion treated in this way will demonstrate typical findings of blister beetle vesiculation.…”

Section: Acantholysis Due To Physical Agentsmentioning

confidence: 99%

Mimickers of classic acantholytic diseases

Bhawan

2017

The Journal of Dermatology

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Section: Acantholysis Due To Physical Agentsmentioning

confidence: 99%

Mimickers of classic acantholytic diseases

Bhawan

2017

The Journal of Dermatology

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“…16,17,[23][24][25][26] Proprietary formulations consisting of 0.7% cantharidin in a film-forming vehicle containing acetone, ether, and alcohol can be purchased from several companies (eg, Dormer Laboratories, Rexdale, Ontario; Omniderm, Hudson, Quebec; PharmaScience, Montreal, Quebec; College Pharmacy, Colorado Springs, Colo; Belle Haven Pharmacy, Alexandria, Va; and Dermatologic Lab and Supply, Council Bluffs, Iowa). Alternatively, compounding 0.7% or 0.9% cantharidin solution with equal parts of acetone and flexible collodion may be done.…”

Section: Dermatological Uses Of Cantharidinmentioning

confidence: 99%

“…30 There is no scarring with proper use. 16,24 Adverse effects include a ring of small satellite warts surrounding the original wart. Ring warts occurred in 1 of 100 patients in one study 28 and in 3 of 61 patients in another.…”

Section: Dermatological Uses Of Cantharidinmentioning

confidence: 99%

Cantharidin Revisited

Moed

Shwayder²,

Chang³

2001

Arch Dermatol

175

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antharidin, a vesicant produced by beetles in the order Coleoptera, has a long history in both folk and traditional medicine. In dermatology, topical cantharidin has long been used to treat warts and molluscum. In 1962, cantharidin lost Food and Drug Administration (FDA) approval owing to the failure of its manufacturers to submit data attesting to cantharidin's efficacy. However, it is expected that the FDA will soon include cantharidin on its "Bulk Substances List," which would permit physicians or pharmacists to compound cantharidin to be used in the office for individual patients. A comprehensive discussion of the origins, folk uses, current FDA status, current dermatologic uses, and effects of cantharidin poisoning has been compiled herein. No cases of systemic intoxication or scarring have been reported with the proper use of cantharidin by a physician. Cantharidin is a safe and valuable medication and should be readded to the dermatologic therapeutic armamentarium.

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“…Lee et al (2013) suggest that norcantharidin exhibits anticancer effects against non-small cell lung cancer cells in vitro, and his report supports the potential use of Norcantharidin as a chemotherapeutic agent for treating non-small cell lung cancer. Topical cantharidin in a collodion vehicle has been used by dermatologists in the treatment for warts and molluscum contagiosum since the 1950s (Funt 1961). Moye et al (2014) has reported that Cantharidin is a safe treatment modality for molluscum contagiosum and should be considered when symptomatic infection necessitates treatment (Kadioglu et al 2014).…”

Section: Beetles (Cantharidin)mentioning

confidence: 99%

Helminthes and insects: maladies or therapies

El-Tantawy

2014

Parasitol Res

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By definition, parasites cause harm to their hosts. But, considerable evidence from ancient traditional medicine has supported the theory of using parasites and their products in treating many diseases. Maggots have been used successfully to treat chronic, long-standing, infected wounds which failed to respond to conventional treatment by many beneficial effects on the wound including debridement, disinfection, and healing enhancement. Maggots are also applied in forensic medicine to estimate time between the death and discovery of a corpse and in entomotoxicology involving the potential use of insects as alternative samples for detecting drugs and toxins in death investigations. Leeches are segmented invertebrates, famous by their blood-feeding habits and used in phlebotomy to treat various ailments since ancient times. Leech therapy is experiencing resurgence nowadays in health care principally in plastic and reconstructive surgery. Earthworms provide a source of medicinally useful products with potential antimicrobial, antiviral, and anticancer properties. Lumbrokinases are a group of fibrinolytic enzymes isolated and purified from earthworms capable of degrading plasminogen-rich and plasminogen-free fibrin and so can be used to treat various conditions associated with thrombotic diseases. Helminth infection has been proved to have therapeutic effects in both animal and human clinical trials with promising evidence in treating many allergic diseases and can block the induction of or reduce the severity of some autoimmune disorders as Crohn's disease or ulcerative colitis. What is more, venomous arthropods such as scorpions, bees, wasps, spiders, ants, centipedes, snail, beetles, and caterpillars. The venoms and toxins from these arthropods provide a promising source of natural bioactive compounds which can be employed in the development of new drugs to treat diseases as cancer. The possibility of using these active molecules in biotechnological processes can make these venoms and toxins a valuable and promising source of natural bioactive compounds. The therapeutic use of helminthes and insects will be of great value in biomedicine and further studies on insect toxins will contribute extensively to the development of Biomedical Sciences.

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Cantharidin Treatment of Molluscum Contagiosum

Cited by 21 publications

References 2 publications

Mimickers of classic acantholytic diseases

Mimickers of classic acantholytic diseases

Cantharidin Revisited

Helminthes and insects: maladies or therapies

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