2020
DOI: 10.1101/2020.01.14.905919
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Canonical Wnt-signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons

Abstract: In adult hippocampal neurogenesis neural stem/progenitor cells generate new dentate granule neurons that contribute to hippocampal plasticity. The establishment of a morphologically defined dendritic arbor is central to the functional integration of adult-born neurons. Here, we investigated the role of canonical Wnt/-catenin-signaling in dendritogenesis of adult-born neurons. We show that canonical Wnt-signaling follows a biphasic pattern, with high activity in stem/progenitor cells, attenuation in early imma… Show more

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(5 citation statements)
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“…Growing evidence suggest that the Wnt signaling pathway is part of the signaling mechanisms affected, that might contribute to the decline in neurogenesis (Figure 2). In support of this idea, β-catenin reporter mice exhibit a strong decrease in β-catenin signaling activity in the GCL with age, and increasing β-catenin activity counteracts the age-associated maturation defects of adult-born dentate granule neurons (Heppt et al, 2020). In addition, the expression of Wnt3 and Wnt3a in the dentate gyrus decreases with age, concomitantly with the decrease in newborn neurons positive for NeuroD1 (Okamoto et al, 2011).…”
Section: Wnt Signaling In the Decline Of Neurogenesis In The Aging Himentioning
confidence: 86%
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“…Growing evidence suggest that the Wnt signaling pathway is part of the signaling mechanisms affected, that might contribute to the decline in neurogenesis (Figure 2). In support of this idea, β-catenin reporter mice exhibit a strong decrease in β-catenin signaling activity in the GCL with age, and increasing β-catenin activity counteracts the age-associated maturation defects of adult-born dentate granule neurons (Heppt et al, 2020). In addition, the expression of Wnt3 and Wnt3a in the dentate gyrus decreases with age, concomitantly with the decrease in newborn neurons positive for NeuroD1 (Okamoto et al, 2011).…”
Section: Wnt Signaling In the Decline Of Neurogenesis In The Aging Himentioning
confidence: 86%
“…Interestingly, β-catenin reporter mouse lines showed a peak of Wnt/β-catenin activity during early stages of adult hippocampal neurogenesis. Different transgenic reporter mouse lines have been used to evaluate the activity of Wnt/β-catenin signaling in the dentate gyrus: the BATGAL mice (Lie et al, 2005;Garbe and Ring, 2012;Heppt et al, 2020), the ins-topGal mice (Garbe and Ring, 2012), and the Axin2 LacZ/+ mice (Heppt et al, 2020). Although the expression pattern of the reporter activity is not exactly the same in the different mouse lines likely for the molecular construct of the transgenes, the use of BrdU birth-dating strategies and specific molecular markers together with the reporter activity showed that Wnt/β-catenin signaling is active during early stages of adult hippocampus neurogenesis (including NPCs and proliferating neuroblasts), and is attenuated in immature neurons (Lie et al, 2005;Garbe and Ring, 2012;Heppt et al, 2020).…”
Section: Wnt Receptors and Co-receptorsmentioning
confidence: 99%
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