Canonical and non-canonical PRC1 differentially contribute to the regulation of neural stem cell fate
Janine Hoffmann,
Theresa M. Schütze,
Annika Kolodziejczyk
et al.
Abstract:Neocortex development is characterized by sequential phases of neural progenitor cell (NPC) expansion, neurogenesis and gliogenesis. Polycomb-mediated epigenetic mechanisms are known to play important roles in regulating the lineage potential of NPCs during development. The composition of Polycomb Repressive Complex 1 (PRC1) is highly diverse in mammals and was hypothesized to contribute to context-specific regulation of cell fate. Here, we have performed side-by-side comparison of the role of canonical PRC1.2… Show more
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