Cannabis with high Δ9-THC contents affects perception and visual selective attention acutely: An event-related potential study

Böcker, K.B.E.; Gerritsen, Jeroen; Hunault, Claudine C.; Kruidenier, Maaike; Mensinga, Tj.T.; Kenemans, J. Leon

doi:10.1016/j.pbb.2010.04.008

Cited by 48 publications

(45 citation statements)

References 64 publications

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“…This profile of effects is consistent with the published data using two-stimuli P300 paradigms (Bocker et al, 2010;Ilan et al, 2004;Roser et al, 2008). Amplitude of the P300b is thought to reflect attentional resource allocation, phasic attentional shifts, working memory updating of stimulus context, cognitive closure, and stimulus salience (Donchin and Coles, 1988;Knight and Scabini, 1998;Kramer and Strayer, 1988;Polich, 1989;Verleger et al, 2005).…”

supporting

confidence: 88%

Dose-Related Modulation of Event-Related Potentials to Novel and Target Stimuli by Intravenous Δ9-THC in Humans

D’Souza

Fridberg

Skosnik

et al. 2012

Neuropsychopharmacol

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Cannabinoids induce a host of perceptual alterations and cognitive deficits in humans. However, the neural correlates of these deficits have remained elusive. The current study examined the acute, dose-related effects of delta-9-tetrahydrocannabinol (D 9 -THC) on psychophysiological indices of information processing in humans. Healthy subjects (n ¼ 26) completed three test days during which they received intravenous D 9 -THC (placebo, 0.015 and 0.03 mg/kg) in a within-subject, double-blind, randomized, cross-over, and counterbalanced design. Psychophysiological data (electroencephalography) were collected before and after drug administration while subjects engaged in an event-related potential (ERP) task known to be a valid index of attention and cognition (a three-stimulus auditory 'oddball' P300 task). -THC-induced perceptual alterations. Lastly, exploratory analyses examining cannabis use status showed that whereas recent cannabis users had blunted behavioral effects to D 9 -THC, there were no dose-related effects of D 9 -THC on P300a/b amplitude between cannabis-free and recent cannabis users. Overall, these data suggest that at doses that produce behavioral and subjective effects consistent with the known properties of cannabis, D 9-THC reduced P300a and P300b amplitudes without altering the latency of these ERPs. Cannabinoid agonists may therefore disrupt cortical processes responsible for context updating and the automatic orientation of attention, while leaving processing speed and earlier sensory ERP components intact. Collectively, the findings suggest that CB1R systems modulate top-down and bottom-up processing.

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supporting

confidence: 88%

Dose-Related Modulation of Event-Related Potentials to Novel and Target Stimuli by Intravenous Δ9-THC in Humans

D’Souza

Fridberg

Skosnik

et al. 2012

Neuropsychopharmacol

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“…Although smoking cannabis or D 9 -THC diminished the response of pupillary constriction to a flash of light (phasic response), they are not able to exert a clear direct effect of modification of the diameter of the pupil, indicating that D 9 -THC has no effect on the mechanisms involved in the regulation of tonic pupil size (Waldorf et al (1995)). Besides the effects on adjustment of the pupillary diameter it has been reported that D 9 -THC affected visual selective attention (Bocker et al, 2010) and reduced binocular depth inversion (Leweke et al, 1999;Semple et al, 2003) in humans. Although it was not identified a specific anatomical substrate responsible for the cannabinoid-induced visual impairment in rodents, some studies have shown that CB 1 receptors are critically involved in the modulation of visual cortical plasticity in mice (Liu et al, 2008;Garkun and Maffei, 2014) and that D 9 -THC inhibits the visual processes in rat by impairing the thalamocortical transmission (Dasilva et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

JWH-018 impairs sensorimotor functions in mice

et al. 2015

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“…Furthermore, several neuropsychological studies found that cognitive function reverts to normal with prolonged cannabis abstinence [51,65]. Reduced P300 amplitudes during experimental cannabis intoxication in different task settings including the novelty-oddball task [43] were previously reported [38][39][40][41][42]. However, only few studies have investigated P300 amplitudes in chronic cannabis users.…”

Section: Discussionmentioning

confidence: 99%

“…Whereas widely varying results have been obtained after long-term abstinence across different studies [14,[35][36][37], the oddball P300 amplitude is clearly reduced during acute cannabis intoxication [38][39][40][41][42]. Furthermore, a recent study by D'Souza et al [43] demonstrated both reduced novelty P300 and oddball P300 amplitudes by intravenous delta-9-tetrahydrocannabinol in healthy subjects.…”

Section: Introductionmentioning

confidence: 97%

Attentional dysfunction in abstinent long-term cannabis users with and without schizophrenia

Rentzsch

Stadtmann

Montag

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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Long-term cannabis use may confer cognitive deficits and increased risk of psychosis. However, the relationship between cannabis use and schizophrenia is complex. In particular, little is known about the effects of chronic cannabis use on the attention-related electric brain response in schizophrenia. We investigated auditory novelty and oddball P300 evoked potentials in a mixed sample of first-episode and chronic schizophrenic patients and healthy controls with (SZCA, n = 20; COCA, n = 20, abstinence ≥28 days) or without (SZ, n = 20; CO, n = 20) chronic cannabis use. Duration of regular cannabis use was 8.3 ± 5.6 (SZCA) and 9.1 ± 7.1 (COCA) years. In general, schizophrenic patients showed reduced P300 amplitudes. Cannabis use was associated with both a reduced early and late left-hemispheric novelty P300. There was a significant 'diagnosis × cannabis' interaction for the left-hemispheric late novelty P300 in that cannabis use was associated with a reduced amplitude in the otherwise healthy but not in the schizophrenic group compared with their relative control groups (corrected p < 0.02; p > 0.9, respectively). The left-hemispheric late novelty P300 in the otherwise healthy cannabis group correlated inversely with amount and duration of cannabis use (r = -0.50, p = 0.024; r = -0.57, p = 0.009, respectively). Our study confirms attentional deficits with chronic cannabis use. However, cannabis use may lead to different cognitive sequelae in patients with schizophrenia and in healthy controls, possibly reflecting preexisting alterations in the endocannabinoid system in schizophrenia.

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Cannabis with high Δ9-THC contents affects perception and visual selective attention acutely: An event-related potential study

Cited by 48 publications

References 64 publications

Dose-Related Modulation of Event-Related Potentials to Novel and Target Stimuli by Intravenous Δ9-THC in Humans

Dose-Related Modulation of Event-Related Potentials to Novel and Target Stimuli by Intravenous Δ9-THC in Humans

JWH-018 impairs sensorimotor functions in mice

Attentional dysfunction in abstinent long-term cannabis users with and without schizophrenia

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