Cannabis use and cognitive functioning in first-episode schizophrenia patients

Rodríguez-Sánchez, José Manuel; Ayesa-Arriola, Rosa; Mata, Ignacio; Moreno-Calle, T.; Pérez-Iglesias, Rocí­o; González‐Blanch, César; Periáñez, José A; Vázquez‐Barquero, José Luís; Crespo‐Facorro, Benedicto

doi:10.1016/j.schres.2010.08.017

Cited by 53 publications

(38 citation statements)

References 62 publications

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“…It has been hypothesized that repeated cannabis exposure may disrupt-rather than enhance-the normal neuroprotective function of the endocannabinoid system, causing excess glutamate release, exaggerated synaptic pruning, and excitotoxicity (James et al, 2013). These differential findings imply that progressive brain changes in schizophrenia may be moderated by variability in baseline age, specific characteristics of cannabis use (i.e., dose, developmental time window, duration of exposure, and composition of cannabis) (Sarne and Mechoulam, 2005), antipsychotic medication exposure (Dorph-Petersen et al, 2005;Ho et al, 2011), and/or pre-existing differences in premorbid adjustment (DeRosse et al, 2010;Rodriguez-Sanchez et al, 2010).…”

Section: Effect Of Cud On Cortical Gm Development In Schizophreniamentioning

confidence: 99%

Altered cortical maturation in adolescent cannabis users with and without schizophrenia

Epstein

Kumra

2015

Schizophrenia Research

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Section: Effect Of Cud On Cortical Gm Development In Schizophreniamentioning

confidence: 99%

Altered cortical maturation in adolescent cannabis users with and without schizophrenia

Epstein

Kumra

2015

Schizophrenia Research

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“…In contrast to the alcohol studies, the majority (9 out of 12) of the studies involving patients with schizophrenia with or without comorbid cannabis use/abuse found that those with both schizophrenia and cannabis use/abuse had relatively better cognitive functioning (Coulston, Perdices, & Tennant, 2007a;DeRosse, Kaplan, Burdick, Lencz, & Malhotra, 2010;JockersScherübl et al, 2007;Leeson, Harrison, Ron, Barnes, & Joyce, 2011;Loberg & Hughdahl, 2009;Rodriguez-Sanchez et al, 2010;Schnell, Koethe, Daumann, & Gouzoulis-Mayfrank, 2009;Sevy et al, 2007;Yücel et al, 2010; Table 2). Various cognitive domains have been shown to be better in patients with schizophrenia and cannabis abuse, such as speed of processing (six studies), reasoning and problem solving (four studies), verbal memory (three studies), working memory (four studies), attention (two studies), and language/verbal abilities (two studies).…”

Section: Cannabis Studiesmentioning

confidence: 98%

“…From the studies on cognition that were reviewed in this paper, differences between patients with schizophrenia only and those with dual disorders have also been reported, especially in terms of age, sex, and positive symptoms. Regardless of the substance abused, 10 studies contained patients with dual disorders who were significantly younger than patients with schizophrenia only (Coulston et al, 2007a;Jockers-Scherübl et al, 2007;Leeson et al, 2011;Mata et al, 2008;Ringen et al, 2010;Rodriguez-Jimenez et al, 2010;Rodriguez-Sanchez et al, 2010;Thoma et al, 2007;Thoma & Daum, 2008;Wobrock et al, 2007). Eight studies showed that patients with dual disorders had increased positive symptoms, relative to patients with schizophrenia only (Addington & Addington, 1997;Bowie et al, 2005;Cleghorn et al, 1991;Potvin et al, 2005;Ringen et al, 2010;Rodriguez-Jimenez et al, 2010;Schnell et al, 2009;Yücel et al, 2010).…”

Section: Study Limitationsmentioning

confidence: 99%

Paradoxical Cognitive Capacities in Dual Diagnosis Schizophrenia: The Quest for Explanatory Factors

Potvin

MPs

2012

Journal of Dual Diagnosis

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Objective: Individuals with either schizophrenia or a substance use disorder have been shown to independently display cognitive deficits. Patients with schizophrenia who abuse psychoactive substances should then arguably display an aggravation in cognitive impairment. However, cognitive integrity among individuals with dual diagnosis remains paradoxical, with some studies reporting dysfunction and others reporting preservation. Methods: A literature search of PubMed and PsycInfo was conducted using the following major inclusion criteria: (a) schizophrenia-spectrum disorder, (b) presence or absence of a substance use disorder, and (c) measures of cognitive function. Results: Young patients with schizophrenia and comorbid substance abuse typically display better cognitive abilities than older individuals with dual diagnosis. Also, depending on the type of task assessed, cognition either remains relatively intact (e.g., psychomotor speed), dysfunctional (e.g., verbal memory), or ambiguous (e.g., impulsivity). Performance on tasks of impulsivity, however, remains particularly difficult to interpret, most probably due to the complexity of the multidimensional construct of this cognitive domain. Finally, depending on the preference of psychoactive substance used, some individuals with dual diagnosis exhibit better cognitive function (e.g., cannabis), while others display marked decreases on task performance (e.g., alcohol), relative to those with schizophrenia only. Conclusions: Age, type of cognitive function measured, and type of psychoactive substance abused appear to be three factors that interact to contribute to the array of current findings among patients with dual diagnoses of schizophrenia and substance use disorder. (Journal of Dual Diagnosis, 8:35-47, 2012)

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“…Wobrock et al, 2013). Furthermore, for cannabis, superior cognitive functioning in the illicit drug using group has been reported in first episode psychosis patients (Rodriguez-Sanchez et al, 2010;Cunha et al, 2013) and at 10-year follow-up after onset of psychosis (Stirling et al, 2005), and replicated by means of functional Magnetic Resonance Imaging (fMRI) (Løberg et al, 2012). Whilst intake of THC has been associated with transient cognitive deficits (D'Souza et al, 2005(D'Souza et al, , 2009, mixed results for the intake of stimulants have been reported with both better (Barch and Carter, 2005;Bahorik et al, 2013) and worse (Meijer et al, 2012) cognitive performance in non-affective psychosis.…”

Section: Introductionmentioning

confidence: 99%

Cognitive changes in patients with acute phase psychosis—Effects of illicit drug use

Helle¹,

Gjestad²,

Johnsen³

et al. 2014

Psychiatry Research

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Illicit drug use may influence cognition in non-affective psychosis. Previous studies have shown better cognition in psychosis with illicit drug use as compared to psychosis only. Possibly, illicit drug using patients have more transient drug-related cognitive deficits. Thus, the aim of the present study was to examine cognitive change the first weeks after admission to a psychiatric emergency ward, expecting more cognitive improvement at follow-up in the illicit drug group as compared to psychosis only. Patients with acute non-affective psychosis with (26%) and without illicit drug use were examined at baseline (n=123) and follow-up (n=67), with alternative forms of the Repeatable Battery for the Assessment of Neuropsychological Status. Latent Growth Curve models, controlling for cognition at baseline and age differences between the groups, were used to analyze cognitive change. The illicit drug using patients showed the largest improvement in cognition, especially among the youngest patients. Younger patients with non-affective psychosis and illicit drug use showed more cognitive improvement the first weeks after acute psychosis as compared to psychosis only. This suggests that the illicit drug users constitute a sub-group with less stable cognitive deficits and less cognitive vulnerability.

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Cannabis use and cognitive functioning in first-episode schizophrenia patients

Cited by 53 publications

References 62 publications

Altered cortical maturation in adolescent cannabis users with and without schizophrenia

Altered cortical maturation in adolescent cannabis users with and without schizophrenia

Paradoxical Cognitive Capacities in Dual Diagnosis Schizophrenia: The Quest for Explanatory Factors

Cognitive changes in patients with acute phase psychosis—Effects of illicit drug use

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