Cannabis use and cognitive dysfunction

Shrivastava, Amresh; Johnston, Megan; Tsuang, Ming T.

doi:10.4103/0019-5545.86796

Cited by 41 publications

(20 citation statements)

References 56 publications

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“…Cannabis use was associated with greater alterations in the frontal region comparative to cocaine, suggesting that intoxication and decision making may be dominant in cannabis compared to cocaine use which may be predominately driven by dysregulated reward anticipation. Long term cannabis use has been associated with dysfunctional frontal processes related to cognition such as response time to decision cues and verbal memory [151], [152] while cocaine use has been repeatedly associated with marked dysregulations in motivation and executive functioning [153]- [155]. Moreover, alcohol and nicotine abuse shared common cortical regions and generally showed similar alterations to the other drugs, which may reflect the high rates of co-abuse of nicotine and alcohol in many drug abusers [156], [157].…”

Section: Discussionmentioning

confidence: 99%

Common and separable neural alterations in substance use disorders: evidence from coordinate-based meta-analyses of functional neuroimaging studies in human

Klugah‐Brown

Zweerings

et al. 2020

Preprint

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Delineating common and separable neural alterations in substance use disorders (SUD) is imperative to understand the neurobiological basis of the addictive process and to inform substance-specific treatment strategies. Given numerous functional MRI (fMRI) studies in different SUDs, meta-analysis could provide an opportunity to determine robust shared and substance-specific alterations. The present study employed a coordinate-based meta-analysis covering fMRI studies in individuals with addictive cocaine, cannabis, alcohol, and nicotine use.The primary meta-analysis demonstrated common alterations in primary dorsal striatal, and frontal circuits engaged in reward/salience processing, habit formation, and executive control across different substances and task-paradigms. Subsequent sub-analyses revealed substance-specific alterations in frontal and limbic regions, with marked frontal and insula-thalamic alterations in alcohol and nicotine use disorders respectively. Finally, examining task-specific alterations across substances revealed pronounced frontal alterations during cognitive processes yet stronger striatal alterations during reward-related processes. Together the findings emphasize the role of dysregulations in striato-frontal circuits and dissociable contributions of these systems in the domains of reward-related and cognitive processes which may contribute to substance-specific behavioral alterations.

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Section: Discussionmentioning

confidence: 99%

Common and separable neural alterations in substance use disorders: evidence from coordinate-based meta-analyses of functional neuroimaging studies in human

Klugah‐Brown

Zweerings

et al. 2020

Preprint

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“…Many studies reported that chronic cannabis use leads to cognitive dysfunction. It has been stated that cognitive dysfunction due to cannabis use is generally associated with acute consumption 7,8 . Attention, working memory, verbal learning, and memory are among the most affected cognitive functions [9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

“…Another explanation suggested that cannabis exposure to developing brain may result in permanent structural and functional changes 16 . Therefore, recently the impacts of cannabis use during adolescent period has been examined separately from cannabis use in adulthood 8 . There are studies suggested that cognitive side effects are related with the dose.…”

Section: Introductionmentioning

confidence: 99%

The Changes of the Cognitive and Psychomotor Functions in the Chronic Cannabis Users after a Month of Remission

Umut

Atagün

Evren

et al. 2016

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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ABS TRACT:The changes of the cognitive and psychomotor functions in the chronic cannabis users after a month of remission Objective: In our study, it is aimed to investigate impacts of cannabis use on information processing and psychomotor functions and to examine changes in the cognitive functions at the end of abstinence over a month. Method:The study was initiated with 34 volunteer participants using cannabis at least over two years, directed by a forensic unit. 34 persons were assessed at admission and were planned to assess after a month of remission. As 14 participants discontinued the study 20 participants only were assessed again at the end Results: There was no statistically significant difference between participants continue to the treatment and those discontinue in terms of sociodemographic and clinical characteristics. The participants discontinue were using more daily cannabis dose. The auditory reaction time of the group continue to the treatment decreased statistically significantly after a month whereas there was no statistically significant difference in the visual reaction time. The scores of the AMIPB-A and AMIPB-B were detected statistically higher after a month compared to admission. The score of the dominant hand FTT after a month was detected statistically higher than that in admission whereas there was no statistically significant difference in the non-dominant hand score. Conclusion:Improvements in scores of AMIP-A, AMIP-B, FTT and auditory reaction time after one month of quitting cannabis suggest that cannabis use may impair cognitive functions such as information processing, reaction time and motor functions. We suggest that future studies to assess cognitive functions after either a shorter (i.e. 1 week) or a longer (i.e. 2 months) period of cannabis abstinence in larger samples may provide further useful data about the relationship between cannabis use and cognitive functions.

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“…In spite of some research to the contrary, 16 cannabis has been well proven to precipitate cognition decline. First, it targets and parallels neurological changes similar to that found in schizophrenia.…”

Section: Cognitionmentioning

confidence: 98%

Neuropsychiatric Effects of Marijuana

Wadieh¹

2017

MOJAMT

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Background: Cannabis (Marijuana) is one of the most widely used illicit drugs around the world. In the United States, it is the most commonly-used illicit drug. While there have been increasing numbers of arguments about legalizing marijuana primarily for its medicinal and recreational use, there remain concerns about its impact on the brain: neuropsychiatric problems, in particular, from its chronic use. Purpose & Method:To highlight recent knowledge, understanding and research of marijuana, its potency, mechanism of action, effects on psychomotor and cognitive performance and other neuropsychiatric function are explored; paying particular attention to the long term effects of Marijuana usage. Marijuana interacts with endogenous cannabinoid (CB) systems in the body. Actions on specific brain receptors are reflected in CB dose-related impairments of psychomotor performance. Further effects relating to psychosis, memory problems, and depression, are also experienced; primarily as a result of cortex degeneration. Conclusion:Marijuana significantly impacts the brain, specifically, the brain's structure, function and connectivity. Although marijuana use is linked to many neurological and psychiatric effects from long term use, it is often perceived in society as harmless

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Cannabis use and cognitive dysfunction

Cited by 41 publications

References 56 publications

Common and separable neural alterations in substance use disorders: evidence from coordinate-based meta-analyses of functional neuroimaging studies in human

Common and separable neural alterations in substance use disorders: evidence from coordinate-based meta-analyses of functional neuroimaging studies in human

The Changes of the Cognitive and Psychomotor Functions in the Chronic Cannabis Users after a Month of Remission

Neuropsychiatric Effects of Marijuana

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