“…A limitation of these results was the possibility of overlap between negative PLEs and the amotivational syndrome in cannabis users, which includes social indifference, apathy and passivity (McGlothlin & West, 1968). Despite presenting contradictory evidence (Barnwell, Earleywine, & Wilcox, 2006), possibly related to inconsistency in measurements of the substance use, the amotivational syndrome has been reported in heavy cannabis users who did not, necessarily, present a diagnosis of schizophrenia or psychotic symptoms (Bersani et al, 2016;Looby & Earleywine, 2007;Rovai et al, 2013). However, we consider that this alternative explanation for the results found in the present review is unlikely, since in most studies included in our review, moderate and light users of cannabis reported not only more negative PLEs but also more positive and depressive PLEs as compared to non-users Skinner et al, 2011;Stefanis et al, 2002;Verdoux et al, 2003;.…”