Cannabis and Paternal Epigenetic Inheritance

Mazzeo, Filomena; Meccariello, Rosaria

doi:10.3390/ijerph20095663

Cited by 5 publications

(2 citation statements)

References 112 publications

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“…Data from studies on rodents have shown that preconcpeptional paternal exposure to delta-9-tetrahydrocannabinol (∆9-THC), the most active cannabinoid, leads to deficits in cholinergic synaptic function in offspring, along with abnormalities in locomotor activity, impaired cognitive function, and long-lasting neurobehavioral effects. Additionally, exposure to ∆9-THC during adolescence in rats has been found to cause intergenerational effects on DNA methylation status in the nucleus accumbens (NAc) [158].…”

Section: Transgenerational Consequences Of Epigenetic Changes In Sper...mentioning

confidence: 99%

Oxidative Stress Biomarkers in Male Infertility: Established Methodologies and Future Perspectives

Mottola,

Palmieri,

Carannante

et al. 2024

Genes

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Male fertility can be affected by oxidative stress (OS), which occurs when an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to neutralize them arises. OS can damage cells and influence sperm production. High levels of lipid peroxidation have been linked to reduced sperm motility and decreased fertilization ability. This literature review discusses the most commonly used biomarkers to measure sperm damage caused by ROS, such as the high level of OS in seminal plasma as an indicator of imbalance in antioxidant activity. The investigated biomarkers include 8-hydroxy-2-deoxyguanosine acid (8-OHdG), a marker of DNA damage caused by ROS, and F2 isoprostanoids (8-isoprostanes) produced by lipid peroxidation. Furthermore, this review focuses on recent methodologies including the NGS polymorphisms and differentially expressed gene (DEG) analysis, as well as the epigenetic mechanisms linked to ROS during spermatogenesis along with new methodologies developed to evaluate OS biomarkers. Finally, this review addresses a valuable insight into the mechanisms of male infertility provided by these advances and how they have led to new treatment possibilities. Overall, the use of biomarkers to evaluate OS in male infertility has supplied innovative diagnostic and therapeutic approaches, enhancing our understanding of male infertility mechanisms.

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Section: Transgenerational Consequences Of Epigenetic Changes In Sper...mentioning

confidence: 99%

Oxidative Stress Biomarkers in Male Infertility: Established Methodologies and Future Perspectives

Mottola,

Palmieri,

Carannante

et al. 2024

Genes

View full text Add to dashboard Cite

show abstract

“…In Western countries, the recreational use of illicit drugs, such as cannabis, is common mainly in male adolescents and young men, with several negative life outcomes like depression, substance use disorders, and psychosis, as well as social impacts [ 27 , 28 ]. In this respect, adolescence is a critical period for the completion of several developmental processes, including neurodevelopment and reproductive functions [ 15 , 28 , 29 ]. Hence, cannabis use during adolescence might epigenetically impact brain health, and thus deserves attention.…”

mentioning

confidence: 99%