Cannabis and opioid overdoses: time to move on and examine potential mechanisms

Røgeberg, Ole; Blomkvist, Andreas Wahl; Nutt, David

doi:10.1111/add.14238

Cited by 8 publications

(6 citation statements)

References 18 publications

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“…We agree with Rogeberg et al [4] that larger, better-designed studies are needed to test possible mechanisms for a causal effect, such as substitution of cannabinoids for opioids or other central nervous system (CNS) depressants. The hypothesis given greatest prominence in the media-the substitution of opioids for pain relief-is the least plausible because of the weak analgesic effects of cannabinoids in clinical trials of chronic pain.…”

Section: The Need For More Consistent Evidential Standards In Cannabisupporting

confidence: 86%

The need for more consistent evidential standards in cannabis policy evaluations

et al. 2018

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Section: The Need For More Consistent Evidential Standards In Cannabisupporting

confidence: 86%

The need for more consistent evidential standards in cannabis policy evaluations

et al. 2018

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“…Nor should they warrant the use of different evidential standards to evaluate the risks and the benefits of cannabis use; such as, for example, uncritically accepting weak evidence for medical benefits while dismissing epidemiological evidence for causal relationships between cannabis use and adverse health effects as 'correlational' (e.g. [5,9]).…”

Section: Some Critics Of Publicly Funded Research On Cannabis Use Arguementioning

confidence: 99%

“…Since around the turn of the millennium, however, research has focused more upon the putative medical benefits of cannabis that have been used to justify the legalization of its medical use [4]. Some of this research has been of low quality, such as ecological associations between the presence or absence of state medical cannabis programmes and trends in opioid overdose deaths [5], case series [6] and poorly controlled observational studies of patient outcomes in the absence of comparison conditions [7].…”

mentioning

confidence: 99%

Minimizing double standards in assessing the adverse and beneficial effects of cannabis

Hall

Hoch

2023

Addiction

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“…In the past, reports of harm associated with cannabis use were often uncritically embraced as providing support for a continuation of prohibition; today, equivocal evidence of medical benefits is used to justify more liberal medical cannabis policies (eg, ref 29). Evidential double standards are exemplified in the very different evaluations made of observational evidence on the benefits and adverse effects of cannabis use.…”

Section: Depenalization Of Personal Possession and Usementioning

confidence: 99%

The costs and benefits of cannabis control policies

Hall

2020

Dialogues in Clinical Neuroscience

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As is the case for most drugs, cannabis use has costs and benefits, and so do the policies that attempt to minimize the first and maximize the second. This article summarizes what we know about the harmful effects of recreational cannabis use and the benefits of medical cannabis use under the policy of prohibition that prevailed in developed countries until 2012. It outlines three broad ways in which cannabis prohibition may be relaxed, namely, the depenalization of personal possession and use, the legalization of medical use, and the legalization of adult recreational use. It reviews evidence to date on the impacts of each of these forms of liberalization on the costs and benefits of cannabis use. It makes some plausible conjectures about the future impacts of the commercialization of cannabis using experience from the commercialization of the alcohol, tobacco, and gambling industries. Cannabis policy entails unavoidable trade-offs between competing social values in the face of considerable uncertainty about the effects that more liberal cannabis policies will have on cannabis use and its consequences for better or worse.

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Cannabis and opioid overdoses: time to move on and examine potential mechanisms

Cited by 8 publications

References 18 publications

The need for more consistent evidential standards in cannabis policy evaluations

The need for more consistent evidential standards in cannabis policy evaluations

Minimizing double standards in assessing the adverse and beneficial effects of cannabis

The costs and benefits of cannabis control policies

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