Cannabinoids suppress the innate immune response to periodontal pathogen Porphyromonas gingivalis in gingival epithelial cells.

Niyogi, Rajarshi Guha

doi:10.18297/etd/2503

Cited by 1 publication

(1 citation statement)

References 82 publications

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“…Anti‐inflammatory actions of cannabinoids may be through CB2 surface receptors, because drug inhibition of CB2 receptors does not lead to the reversal of the innate immune response to bacterial stimuli in epithelial cells. One study found that specific inhibitors, such as AM630, and small interfering RNA, an inhibitor that silences the CB2 gene, could be used to determine the importance of CB2 in inhibiting the innate response to plaque pathogens and gingival epithelial cells (Niyogi, 2016).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of cannabinoid receptors type 1–2 in periodontitis patients

Ataei

Rezaee

Moeintaghavi

et al. 2022

Clinical & Exp Dental Res

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Background: As effective immune modulators, Endocannabinoids may suppress the inflammatory responses in periodontitis. This study assessed the expression of cannabinoid receptors in gingiva and the impact on periodontitis. Methods:A cross-sectional study on 20 patients with more than stage II and Grade A periodontitis and a control group consisting of 19 healthy individuals was performed. The gingival biopsies were assessed for the expression of CB1 and CB2 using the quantitative reverse transcription polymerase chain reaction, TaqMan method. Results:The study sample consisted of 39 subjects, 31 females (79.5%) and 8 males (20.5%), including 20 periodontitis subjects (80% female and 20% male), and control groups (78.9% female and 21.1% male). The mean ages of cases and controls were 33.3 ± 4.7 and 35.7 ± 5.1 years, respectively. The gene expression of CB2 in periodontitis was 27.62 ± 7.96 and in healthy subjects was 78.15 ± 23.07. The CB2 was significantly lower than the control group (p = .008). In comparison, the gene expression index of CB1 in the periodontal group (9.42 ± 3.03) was higher than the control group (6.62 ± 1.13) but did not meet a significant value (p = .671). Conclusion:The lower expression of CB2 receptors in the periodontitis group may be due to the reduced protective effect of anti-inflammatory agents. These elements include cannabinoids and the imbalance leading to the predominance of proinflammatory effects. Therefore, the local effects of cannabinoids as an immunomodulator could be useful for oral inflammatory diseases such as periodontitis.

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Section: Discussionmentioning

confidence: 99%