Cannabinoids – Influence on the Immune System and Their Potencial Use in Supplementary Therapy of HIV/AIDS

Szulakowska, Alicja; Milnerowicz, Halina

doi:10.5772/20420

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2016

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“…The major psychoactive component of marijuana, Δ9‐tetrahydrocannabinol, has been reported to suppress immune functions, including cell proliferation, antibody production, natural killer cell activity and macrophage function . Impaired rosetting capacity has been observed in the peripheral blood CD4 and CD8 lymphocytes subsets of marijuana users . Cannabinoids may also have important effects on T helper 1‐ and 2‐specific cytokines and TGF‐β secretion .…”

Section: Discussionmentioning

confidence: 99%

No significant effect of cannabis use on the count and percentage of circulating CD4 T‐cells in HIV‐HCV co‐infected patients (ANRS CO13‐HEPAVIH French cohort)

Marcellin

Lions

Rosenthal

et al. 2016

Drug and Alcohol Review

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Findings show no evidence for a negative effect of cannabis use on circulating CD4 T-cell counts/percentages in HIV-HCV co-infected patients. In-depth immunological studies are needed to document whether cannabis has a harmful effect on CD4 levels in lungs and on cells' functional properties. [Marcellin F, Lions C, Rosenthal E, Roux P, Sogni P, Wittkop L, Protopopescu C, Spire B, Salmon-Ceron D, Dabis F, Carrieri MP, HEPAVIH ANRS CO13 Study Group. No significant effect of cannabis use on the count and percentage of circulating CD4 T-cells in HIV-HCV co-infected patients (ANRSCO13-HEPAVIH French cohort). Drug Alcohol Rev 2017;36:227-238].

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Section: Discussionmentioning

confidence: 99%