Cannabinoids in Pain Treatment: An Overview

Mallick-Searle, Theresa; Marie, Barbara St.

doi:10.1016/j.pmn.2018.12.006

Cited by 12 publications

(3 citation statements)

References 43 publications

(42 reference statements)

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“…(35) The main components of the ECS are as follows: two "classical" endocannabinoid ligands, namely N-arachidonoyl ethanolamine anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and "classical" cannabinoid receptors, namely type 1 (CB1) and type 2 (CB2). (35)(36)(37)(38)(39)(40)(41)(42)(43)(44) Besides the CNS, CB1 and CB2 have also been discovered in the immune system (45)(46)(47) and MSCs and participate in their regenerative and immunomodulatory processes. (48,49) Studies on the role of the ECS in MSCs have been scarce.…”

Section: ❚ Introductionmentioning

confidence: 99%

Tumor necrosis factor α, and agonist and antagonists of cannabinoid receptor type 1 and type 2 alter the immunophenotype of stem cells from human exfoliated deciduous teeth

Trevizani,

Leal,

Rettore

et al. 2023

Einstein (São Paulo)

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Objective To verify the involvement of the endocannabinoid system in the immunomodulatory profile of stem cells from human exfoliated deciduous teeth, in the presence or absence of TNF-α, and agonist and antagonists of CB1 and CB2. Methods Stem cells from human exfoliated deciduous teeth were cultured in the presence or absence of an agonist, anandamide, and two antagonists, AM251 and SR144528, of CB1 and CB2 receptors, with or without TNF-α stimulation. For analysis of immunomodulation, surface molecules linked to immunomodulation, namely human leukocyte antigen-DR isotype (HLA-DR), and programmed death ligands 1 (PD-L1) and 2 (PD-L2) were measured using flow cytometry. Results The inhibition of endocannabinoid receptors together with the proinflammatory effect of TNF-α resulted in increased HLA-DR expression in stem cells from human exfoliated deciduous teeth, as well as, in these cells acquiring an anti-inflammatory profile by enhancing the expression of PD-L1 and PD-L2. Conclusion Stem cells from human exfoliated deciduous teeth respond to the endocannabinoid system and TNF-α by altering key immune response molecules.

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Section: ❚ Introductionmentioning

confidence: 99%

Tumor necrosis factor α, and agonist and antagonists of cannabinoid receptor type 1 and type 2 alter the immunophenotype of stem cells from human exfoliated deciduous teeth

Trevizani,

Leal,

Rettore

et al. 2023

Einstein (São Paulo)

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“…The ECS consists of a family of receptors, endogenous ligands, and the molecular machinery for their synthesis, being best described in the central nervous system (CNS) [35]. Its main components are: the two "classical" endocannabinoid ligands, N-arachidonoyl ethanolamine (anandamide; AEA) and 2-arachidonoylglycerol (2-AG); and the also "classical" CB1 and CB2 [35][36][37][38][39][40][41][42][43][44]. Outside of the CNS, CB1 and CB2 have been identi ed in the immune system [45][46][47] as well as in MSC and theirs regenerative and immunomodulatory processes [48][49].…”

Section: Introductionmentioning

confidence: 99%

Tumor necrosis factor α, agonist and antagonists of cannabinoid receptor type 1 and type 2 alter the immunephenotype of stem cells from human exfoliated deciduous teeth

Trevizani¹,

Leal²,

Rettore³

et al. 2022

Preprint

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The endocannabinoid system (ECS) is composed of endocannabinoid molecules synthesizing and degrading ligands and cannabinoid receptors such as types CB1 and CB2. The ECS is present in various tissues and cell types, such as in central nervous system, immune system, and mesenchymal stem cells. The presence of these receptors in both immune system cells and stem cells shows a common pathway of communication-related to repair and immunomodulation. The aim of the present study was to verify the participation of ECS in the immunomodulatory profile of stem cells from human exfoliated deciduous teeth (SHED), in the presence or absence of TNF-α. SHED was cultured in the presence or absence of the agonist anandamide and the two antagonists AM251 and SR144528 of CB1 and CB2 receptors, under stimulation or not of TNF-α. For immunomodulation analysis, surface molecules linked to immunomodulation: HLA-DR, PD-L1 and PD-L2 were measured by flow cytometry. The results showed that SHED respond to ECS and TNF-α by altering key molecules of the immune response. It is concluded that the inhibition of endocannabinoid receptors added with the pro-inflammatory effect of TNF-α led SHED to show increased HLA-DR, as well as, to assume an anti-inflammatory profile by increasing PD-L1 and PD-L2.

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“…Desprovido de atividade psicotrópica, o canabidiol tem ação anti-inflamatória, antioxidante e neuroprotetora. Embora o THC e CBD sejam fitocanabinoides mais estudados, existem outras moléculas como canabivarim, canabigerol que vem sendo estudados as propriedades farmacológicas (5)(6)(7) .…”

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Liga Acadêmica de Ciências Cannabicas: uma iniciativa para discussão da Cannabis Medicinal

Macario de Simas Gonçalves,

Eloi Alves,

Lima Fontes-Dantas

et al. 2023

SaudColetiv (Barueri)

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Após a descoberta do sistema endocanabinoide no final do século XX abriram-se as portas para os estudos a respeito da Cannabis na forma de tratamento medicinal. Desde então inúmeros ensaios clínicos mostraram que a Cannabis é eficaz no tratamento de algumas condições médicas e há uma crescente pressão pública e política para promulgar leis que permitam o seu uso para fins medicinais. Com o intuito de propiciar a divulgação de informações científicas verdadeiras e acessíveis para a sociedade, a Universidade do Estado do Rio de Janeiro organizou um projeto de extensão universitária intitulada Liga de Ciências Cannábicas (LACICAN). Este artigo tem o objetivo de relatar as ações do projeto de extensão universitária voltadas para a discussão da Cannabis Medicinal. Diferentes materiais informativos, com linguagem acessível foram produzidos e divulgados via redes sociais desde abril de 2022 até o e julho de 2023. Além disso, a LACICAN organizou o seu primeiro ciclo de debates sobre Cannabis Medicinal em 2022 de forma remota, com palestrantes renomados na área. Ao final do evento, os participantes responderam um questionário online a fim de entendermos os conhecimentos teóricos adquiridos. Na nossa principal rede social, o Instagram®, que já tem 32 publicações desde sua criação, com 1699 curtidas e 254 comentários no total. Durante o ciclo de debates, conseguimos reunir mais de 130 inscritos das regiões Sudeste (64 %), Nordeste (31%) e Sul (5%) do Brasil. Interessantemente, 100 % dos participantes, relataram que indicaria o ciclo de debate para alguém em uma próxima edição. Dessa forma, o projeto busca a manutenção do debate entre universidade e a comunidade sobre a Cannabis Medicinal, seu consumo com fins medicinais, legislação e as pesquisas científicas sobre o tema que estão em andamento no Brasil.

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Cannabinoids in Pain Treatment: An Overview

Cited by 12 publications

References 43 publications

Tumor necrosis factor α, and agonist and antagonists of cannabinoid receptor type 1 and type 2 alter the immunophenotype of stem cells from human exfoliated deciduous teeth

Tumor necrosis factor α, and agonist and antagonists of cannabinoid receptor type 1 and type 2 alter the immunophenotype of stem cells from human exfoliated deciduous teeth

Tumor necrosis factor α, agonist and antagonists of cannabinoid receptor type 1 and type 2 alter the immunephenotype of stem cells from human exfoliated deciduous teeth

Liga Acadêmica de Ciências Cannabicas: uma iniciativa para discussão da Cannabis Medicinal

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