Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy

Smith, L. A.; Azariah, Fredric; Lavender, Verna; Stoner, Nicola; Bettiol, SS

doi:10.1002/14651858.cd009464.pub2

Cited by 173 publications

(180 citation statements)

References 125 publications

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“…This research has focused primarily on a handful of the multitude of medical conditions and symptoms for which the benefits of cannabis have been proclaimed anecdotally, including muscle spasm and chronic pain (Borgelt, Franson, Nussbaum, & Wang, 2013; Harrison, Heritier, Childs, Bostwick, & Dziadzko, 2015), nausea and vomiting (Smith, Azariah, Lavender, Stoner, & Bettiol, 2015), epilepsy (Friedman & Devinsky, 2015), appetite stimulation (Gorter, 1999), cancer (Pacher, 2013), and several psychiatric disorders (e.g., post-traumatic stress disorder, anxiety, depression; Betthauser, Pilz, & Vollmer, 2015; Zlebnik & Cheer, 2016). To date, the quality of evidence supportive of cannabinoid treatment for spasticity and chronic pain has been moderate, whereas only low-quality evidence was available to support its use for nausea and vomiting and for weight gain in patients with HIV/AIDS or cancer (for a review, see Whiting et al, 2015).…”

Section: Promises Of Ediblesmentioning

confidence: 99%

Tasty THC: Promises and Challenges of Cannabis Edibles

et al. 2016

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Food products containing cannabis extract (edibles) have emerged as a popular and lucrative facet of the legalized market for both recreational and medicinal cannabis. The many formulations of cannabis extracts used in edibles present a unique regulatory challenge for policy makers. Though edibles are often considered a safe, discreet, and effective means of attaining the therapeutic and/or intoxicating effects of cannabis without exposure to the potentially harmful risks of cannabis smoking, little research has evaluated how ingestion differs from other methods of cannabis administration in terms of therapeutic efficacy, subjective effects, and safety. The most prominent difference between ingestion and inhalation of cannabis extracts is the delayed onset of drug effect with ingestion. Consumers often do not understand this aspect of edible use and may consume a greater than intended amount of drug before the drug has taken effect, often resulting in profoundly adverse effects. Written for the educated layperson and for policy makers, this paper explores the current state of research regarding edibles, highlighting the promises and challenges that edibles present to both users and policy makers, and describes the approaches that four states in which recreational cannabis use is legal have taken regarding regulating edibles.

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Section: Promises Of Ediblesmentioning

confidence: 99%

Tasty THC: Promises and Challenges of Cannabis Edibles

et al. 2016

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“…Existing studies are plagued by small sample sizes and heterogeneity in marijuana products trialed. Domestic restrictions on clinical trials that employ Schedule I controlled substances further hinder investigation on MM . This has led to more research on cannabinoid pharmaceuticals, such as dronabinol, than on MM .…”

Section: Evidence For Medical Marijuana In Cancer Carementioning

confidence: 99%

Medical marijuana in pediatric oncology: A review of the evidence and implications for practice

Ananth

Reed-Weston

Wolfe

2017

Pediatric Blood & Cancer

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Medical marijuana (MM) has become increasingly legal at the state level and accessible to children with serious illness. Pediatric patients with cancer may be particularly receptive to MM, given purported benefits in managing cancer-related symptoms. In this review, we examine the evidence for MM as a supportive care agent in pediatric oncology. We describe the current legal status of MM, mechanism of action, common formulations, and potential benefits versus risks for pediatric oncology patients. We offer suggestions for how providers might approach MM requests. Throughout, we comment on avenues for future investigation on this growing trend in supportive care.

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“…El sistema cannabinoide se compone de receptores cannabinoides (tipo 1 y tipo 2) y su unión a sustancias cannabinoides endógenas (endocannabinoides) 4,6,7 ; sin embargo, los cannabinoides provenientes del cannabis (fitocannabinoides) 8,9 y los elaborados artificialmente (exocannabinoides) 10 tienen la capacidad de unirse a estos receptores, activar el sistema y alterarlo a largo plazo.…”

Section: Sistema Cannabinoideunclassified

“…Desde el punto de vista de las ciencias de la salud existe la posibilidad del uso medicinal de Cannabis sativa por medio de su inhalación, el consumo de infusiones y el uso tópico de cremas derivadas 3,4 . No obstante, también se ha visto que siendo una sustancia adictiva 5,6 podría afectar a los individuos consumidores en aspectos como la función normal del sistema nervioso central y el proceso para la utilización de algunos nutrientes.…”

Section: Introductionunclassified

Efectos del consumo de marihuana en adultos sobre la ingesta y el metabolismo de los nutrientes: una revisión

Basto

Poveda

2017

Rev Esp Nutr Hum Diet

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La marihuana es uno de los psicoactivos más consumidos en Colombia y el mundo. Se ha observado que tiene efectos sobre el sistema nervioso central y, en consecuencia, podría afectar al metabolismo y el estado nutricional de los individuos consumidores. Este artículo pretende evaluar si el consumo de marihuana y la activación del sistema cannabinoide tienen la capacidad de activar mecanismos fisiológicos mediante los cuales se afecte la ingesta de alimentos, el metabolismo de los nutrientes y el estado nutricional de los adultos adictos. Como resultado se encuentra que el consumo de la marihuana puede incrementar los estímulos orexigénicos y disminuir los anorexigénicos, incidiendo en el aumento de la ingesta y en cambios sobre la producción de enzimas importantes para el metabolismo de las grasas. Además, influye en la aparición de alteraciones del estado nutricional de los consumidores relacionadas con una disminución del índice de masa corporal (IMC), lo cual contrasta con los resultados observados a nivel de la ingesta, por lo tanto se resalta la importancia de efectuar estudios profundos que expliquen este cuestionamiento. PALABRAS CLAVE Cannabis;Cannabinoides; Estado Nutricional; Dieta. R E S U M E NEfectos del consumo de marihuana en adultos sobre la ingesta y el metabolismo de los nutrientes: una revisión

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Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy

Cited by 173 publications

References 125 publications

Tasty THC: Promises and Challenges of Cannabis Edibles

Tasty THC: Promises and Challenges of Cannabis Edibles

Medical marijuana in pediatric oncology: A review of the evidence and implications for practice

Efectos del consumo de marihuana en adultos sobre la ingesta y el metabolismo de los nutrientes: una revisión

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