Cannabinoids for drug‐resistant seizures in a critically ill patient—Case report and literature review

Abstract

What is known and objective Drug‐resistant seizures are life‐threatening and contribute to sustained hospitalization. We present the case of a critically ill 28‐year‐old male with Lennox‐Gastaut syndrome who had approximately 30 seizures/day in the intensive care unit. Case description Patient required mechanical ventilation and pharmacologically induced thiopentone coma. He was commenced on cannabidiol and subsequently extubated. He remained seizure‐free thereafter on a combination of cannabidiol and anti‐epileptic medication that predated his critical illness. What is new and Conclusion Our case report provides a unique perspective on the role of cannabidiol in achieving remission from drug‐resistant seizures in critically ill patients.