Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and Vomiting

Rock, Erin M.; Parker, Linda A.

doi:10.3389/fphar.2016.00221

Cited by 39 publications

(33 citation statements)

References 95 publications

(130 reference statements)

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“…In regard to cannabinoid-elicited nausea, Hempel et al (2017) showed that THC was more potent and efficacious in female rats compared to males in decreasing saccharin consumption in a conditioned taste aversion procedure, suggesting that females are more sensitive than males to the aversive effects of THC, or females were better than males at learning the drug-taste association (which the authors concluded may be the case). Interestingly, considerable animal research suggests that cannabinoid treatment could be useful for alleviating chemotherapy-induced nausea and vomiting (Rock and Parker, 2016). Given that women may be more susceptible than men to chemotherapy-induced nausea (Hilarius et al, 2012), sex comparisons of cannabinoids' anti-nausea and anti-emetic effects in animal studies (and analysis of results by sex in human studies) are warranted.…”

Section: Potential Therapeutic Effects Of Cannabis and Cannabinoidsmentioning

confidence: 99%

Sex-Dependent Effects of Cannabis and Cannabinoids: A Translational Perspective

Cooper

Craft

2017

Neuropsychopharmacol.

245

162

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Recent policy changes have led to significant increases in the use of cannabis for both medical and recreational purposes. Although men are more likely to endorse past month cannabis use and are more frequently diagnosed with Cannabis Use Disorder relative to women, a growing proportion of medical cannabis users are reported to be women. The increased popularity of cannabis for medical purposes and the narrowing gap in prevalence of use between men and women raises questions regarding sex-dependent effects related to therapeutic efficacy and negative health effects of cannabis and cannabinoids. The objective of this review is to provide a translational perspective on the sex-dependent effects of cannabis and cannabinoids by synthesizing findings from preclinical and clinical studies focused on sex comparisons of their therapeutic potential and abuse liability, two specific areas that are of significant public health relevance. Hormonal and pharmacological mechanisms that may underlie sex differences in the effects of cannabis and cannabinoids are highlighted.

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Section: Potential Therapeutic Effects Of Cannabis and Cannabinoidsmentioning

confidence: 99%

Sex-Dependent Effects of Cannabis and Cannabinoids: A Translational Perspective

Cooper

Craft

2017

Neuropsychopharmacol.

245

162

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“…THC has many beneficial activities, for example, antiemetic and analgesic, and could be used for the treatment of anorexia, glaucoma, chemotherapy-induced emesis, and several types of cancer. However, its potent psychoactivity prevents or limits its medical use [ 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 ]. Another important promising phytocannabinoid is cannabidiol (CBD).…”

Section: Medicinal Properties Of Cannabinoidsmentioning

confidence: 99%

It Is Our Turn to Get Cannabis High: Put Cannabinoids in Food and Health Baskets

et al. 2020

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Cannabis is an annual plant with a long history of use as food, feed, fiber, oil, medicine, and narcotics. Despite realizing its true value, it has not yet found its true place. Cannabis has had a long history with many ups and downs, and now it is our turn to promote it. Cannabis contains approximately 600 identified and many yet unidentified potentially useful compounds. Cannabinoids, phenolic compounds, terpenoids, and alkaloids are some of the secondary metabolites present in cannabis. However, among a plethora of unique chemical compounds found in this plant, the most important ones are phytocannabinoids (PCs). Over hundreds of 21-22-carbon compounds exclusively produce in cannabis glandular hairs through either polyketide and or deoxyxylulose phosphate/methylerythritol phosphate (DOXP/MEP) pathways. Trans-Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are those that first come to mind while talking about cannabis. Nevertheless, despite the low concentration, cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabinodiol (CBND), and cannabinidiol (CBDL) may have potentially some medical effects. PCs and endocannabinoids (ECs) mediate their effects mainly through CB1 and CB2 receptors. Despite all concerns regarding cannabis, nobody can ignore the use of cannabinoids as promising tonic, analgesic, antipyretic, antiemetic, anti-inflammatory, anti-epileptic, anticancer agents, which are effective for pain relief, depression, anxiety, sleep disorders, nausea and vomiting, multiple sclerosis, cardiovascular disorders, and appetite stimulation. The scientific community and public society have now increasingly accepted cannabis specifically hemp as much more than a recreational drug. There are growing demands for cannabinoids, mainly CBD, with many diverse therapeutic and nutritional properties in veterinary or human medicine. The main objective of this review article is to historically summarize findings concerning cannabinoids, mainly THC and CBD, towards putting these valuable compounds into food, feed and health baskets and current and future trends in the consumption of products derived from cannabis.

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“…36 ). Both nabilone and dronabinol are available in capsules and are used to treat chemotherapy-induced nausea and vomiting, particularly in oncologic patients who have not responded to standard means for control of these conditions 37 . Dronabinol is also used to treat anorexia associated with AIDS (ref.…”

Section: Approved Cannabis-based Productsmentioning

confidence: 99%

“…38 ). Dronabinol is synthetic THC, nabilone is synthetic THC analogue; each of these substances has partially agonistic effect at the cannabinoid CB 1 and cannabinoid CB 2 receptors 37 .…”

Section: Approved Cannabis-based Productsmentioning

confidence: 99%

Medical cannabis in the treatment of cancer pain and spastic conditions and options of drug delivery in clinical practice

Landa¹,

Juřica²,

Slíva³

et al. 2018

BIOMED PAP

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The use of cannabis for medical purposes has been recently legalised in many countries including the Czech Republic. As a result, there is increased interest on the part of physicians and patients in many aspects of its application. This mini review briefly covers the main active substances of the cannabis plant and mechanisms of action. It focuses on two conditions, cancer pain and spasticity in multiple sclerosis, where its effects are well-documented. A comprehensive overview of a few cannabis-based products and the basic pharmacokinetics of marijuana's constituents follows. The review concludes with an outline for preparing cannabis (dried inflorescence) containing drug dosage forms that can be produced in a hospital pharmacy.

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Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and Vomiting

Cited by 39 publications

References 95 publications

Sex-Dependent Effects of Cannabis and Cannabinoids: A Translational Perspective

Sex-Dependent Effects of Cannabis and Cannabinoids: A Translational Perspective

It Is Our Turn to Get Cannabis High: Put Cannabinoids in Food and Health Baskets

Medical cannabis in the treatment of cancer pain and spastic conditions and options of drug delivery in clinical practice

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