Cannabinoid receptor CB1 and CB2 interacting proteins: Techniques, progress and perspectives

Oyagawa, Caitlin R M; Grimsey, Natasha L.

doi:10.1016/bs.mcb.2021.06.011

Cited by 13 publications

(13 citation statements)

References 238 publications

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“…This interpretation is also consistent with the observation that AM4113 is incompletely effective. Since other GPCRs may heterodimerize with CB1, 51 CB1 and the unidentified GPCR could be operating as homo- or heterodimer pairs to mediate AEA block of VGSC ( Figure 7 ).…”

Section: Discussionmentioning

confidence: 99%

Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons

Steiger¹,

Tsintsadze²,

Mattheisen³

et al. 2023

Cell Reports

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Section: Discussionmentioning

confidence: 99%

Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons

Steiger¹,

Tsintsadze²,

Mattheisen³

et al. 2023

Cell Reports

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“…This interpretation is also consistent with the observation that AM4113 is incompletely effective. Since other GPCRs may heterodimerize with CB1 (Oyagawa and Grimsey, 2021), CB1 and the unidentified GPCR could be operating as homo- or heterodimer pairs to mediate AEA block of VGSC (Figure 8).…”

Section: Discussionmentioning

confidence: 99%

Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons

Steiger

Tsintsadze

Mattheisen

et al. 2022

Preprint

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Endogenous cannabinoid signaling is vital for important brain functions and can be modified pharmacologically to treat pain, epilepsy, and posttraumatic stress disorder. Endocannabinoid mediated changes to excitability are predominantly attributed to 2-arachidonoylglycerol at synapses. Here we identify a pathway in the neocortex by which anandamide, the other major endocannabinoid, powerfully inhibits sodium conductances in the soma resulting in a loss of neuronal excitability. This pathway is mediated by the cannabinoid receptor, and its activation results in a decrease of recurrent action potential generation. The synthetic cannabinoid, Win-55, also inhibits VGSC currents indicating this pathway is positioned to mediate the actions of exogenous cannabinoids.

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“…7 CB2 receptors are concentrated in peripheral tissues, particularly in the immune system. 8 The cannabinoid receptors are modulated by fatty acid neurotransmitters termed endocannabinoids or endogenous cannabinoids. The most wellstudied endocannabinoids are anandamide and 2-arachidonylglycerol.…”

Section: The Endocannabinoid Systemmentioning

confidence: 99%

Cannabis Science and Therapeutics: An Overview for Clinicians

Sera,

Hempel‐Sanderoff

2024

The Journal of Clinical Pharma

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Cannabis‐based therapeutics have garnered increasing attention in recent years as patients seek alternative treatments for various medical conditions. This narrative review provides a comprehensive overview of the science behind the medical use of cannabis, focusing on the medical evidence for commonly treated conditions. In addition, the review addresses the practical considerations of using cannabis as a therapeutic agent, offering insights into dosing strategies, variations in cannabinoid formulation, and individual patient responses. Precautions, adverse consequences, and drug interactions are also discussed, with a focus on patient safety and the potential risks associated with cannabis use.This article is protected by copyright. All rights reserved

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Cannabinoid receptor CB1 and CB2 interacting proteins: Techniques, progress and perspectives

Cited by 13 publications

References 238 publications

Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons

Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons

Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons

Cannabis Science and Therapeutics: An Overview for Clinicians

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