Cannabinoid exposure alters learning of zebra finch vocal patterns

Soderstrom, Ken; Johnson, Frank

doi:10.1016/s0165-3806(03)00061-0

Cited by 44 publications

(47 citation statements)

References 14 publications

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“…An important feature of the pattern of the anti-CB 1 receptor labeling that we observed was distinct and dense staining of telencephalic, thalamic, and midbrain regions known to underlie vocal learning (area X, lMAN, and DLM), perception (L2, OV, and MLd), and production (HVC, RA, and Uva). Given this distinct and dense song region labeling, it is perhaps not surprising that periadolescent cannabinoid exposure alters vocal learning (Soderstrom and Johnson, 2003;.…”

Section: Discussionmentioning

confidence: 99%

“…We have found that single daily treatments with a modest dosage (1 mg/ kg) of the cannabinoid agonist WIN55212-2 (WIN) from 50 to 100 days of age (the time course of zebra finch postnatal development is similar to that of the rat) alters vocal learning by reducing: 1) the number of note-types produced and 2) song stereotypy (a measure of song quality developed by Scharff and Nottebohm, 1991). Because these changes did not occur in adults administered the same treatment, the effect is restricted to periods of vocal development (Soderstrom and Johnson, 2003). Further experiments have revealed that these effects on note number and stereotypy are produced independently: stereotypy is reduced by WIN exposure from 50 to 75 days, whereas note numbers are altered by exposure from 75 to 100 days .…”

Section: Indexing Terms: Vocal Development; Cns Maturation; Drugs Of mentioning

confidence: 99%

“…DLM, nucleus dorsolateralis anterior thalami, pars medialis, Ov, nucleus ovoidalis, Uva, nucleus uvaformis, MLd, nucleus mesencephalicus lateralis, pars dorsalis. effects ensue (Soderstrom and Johnson, 2003;. The nature of physiologic changes produced by behavior-altering cannabinoid exposure is the subject of experiments currently underway.…”

Section: Fig 12 A-ementioning

confidence: 99%

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Developmental pattern of CB₁ cannabinoid receptor immunoreactivity in brain regions important to zebra finch (Taeniopygia guttata) song learning and control

Soderstrom

Tian

2006

J of Comparative Neurology

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Zebra finches learn song during distinct developmental stages, making them an important species for studying mechanisms underlying vocal development. Distinct interconnected forebrain regions have been identified as important to specific features of zebra finch vocal learning and production. Because prior experiments have demonstrated that late postnatal exposure to cannabinoid agonists alters zebra finch song learning, we have sought to identify brain regions likely involved in it. By using an affinity-purified polyclonal antibody directed against the zebra finch CB(1) cannabinoid receptor, we have studied staining patterns in groups of males at 25, 50, 75, and >100 days of age (adults). A general waxing and waning of staining intensity were observed over this developmental period. Distinct staining of song-related brain regions was also noted. Early establishment of staining patterns within rostral telencephalic song regions [area X and lateral magnocellular nucleus of the anterior nidopallium (lMAN)] suggests a role in auditory learning. Later establishment and maintenance in adulthood of small somata and neuropil staining within regions of rostral telencephalon [HVC and robust nucleus of the arcopallium (RA)] are consistent with a vocal motor role for cannabinoid signaling. Our results provide insight into brain regions likely responsible for cannabinoid-altered vocal learning and add to accumulating evidence supporting an important role for cannabinoid signaling in CNS development.

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Section: Discussionmentioning

confidence: 99%

Section: Indexing Terms: Vocal Development; Cns Maturation; Drugs Of mentioning

confidence: 99%

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Developmental pattern of CB₁ cannabinoid receptor immunoreactivity in brain regions important to zebra finch (Taeniopygia guttata) song learning and control

Soderstrom

Tian

2006

J of Comparative Neurology

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“…The critical scanning task required efficient overt visual search for a target within a rectangular array of distractors. Interestingly, slowed responses were only found in users with a rather early age of consumption onset (<17; see also Stiglick and Kalant 1985;Soderstrom and Johnson 2003, for age of onset effects in animal studies).…”

Section: Introductionmentioning

confidence: 99%

Long-term effects of cannabis on eye movement control in reading

2010

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“…3, 4 In a vocal learning songbird we have found that early cannabinoid exposure persistently alters the course of vocal development [5][6][7] and expression of endogenous cannabinoid signaling elements. 8 Persistent alterations in behavior that last through adulthood must be attributable to induced changes in the physiology of the CNS substrates responsible.…”

Section: Introductionmentioning

confidence: 99%

Altered patterns of filopodia production in CHO cells heterologously expressing zebra finch CB₁cannabinoid receptors

Soderstrom

Zhang

Wilson

2012

Cell Adhesion & Migration

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Abbreviations: CHO cells, Chinese hamster ovary cells; DMSO, dimethyl sulfoxide; M/C, membrane:cytoplasm; PBS, phosphate-buffered saline; SR, the CB 1 receptor-selective antagonist/inverse agonist SR141716A; WIN, the cannabinoid agonist WIN55212-2; zfCB1, zebra finch CB 1 cannabinoid receptorRecent findings indicate that cannabinoid-altered vocal development involves elevated densities of dendritic spines in a subset of brain regions involved in zebra finch song learning and production suggesting that cannabinoid receptor activation may regulate cell structure. Here we report that activation of zebra finch CB 1 receptors (zfCB 1 , delivered by a lentivector to CHO cells) produces dose-dependent biphasic effects on the mean length of filopodia expressed: Low agonist concentrations (3 nM WIN55212-2) increase lengths while higher concentrations reduce them. In contrast, treatment of zfCB 1 -expressing cells with the antagonist/inverse agonist SR141716A causes increases in both mean filopodia length and number at 30 and 100 nM. These results demonstrate that CB 1 receptor activation can differentially influence filiopodia elongation depending on dose, and demonstrate that manipulation of cannabinoid receptor activity is capable of modulating cell morphology.

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Cannabinoid exposure alters learning of zebra finch vocal patterns

Cited by 44 publications

References 14 publications

Developmental pattern of CB₁ cannabinoid receptor immunoreactivity in brain regions important to zebra finch (Taeniopygia guttata) song learning and control

Developmental pattern of CB₁ cannabinoid receptor immunoreactivity in brain regions important to zebra finch (Taeniopygia guttata) song learning and control

Long-term effects of cannabis on eye movement control in reading

Altered patterns of filopodia production in CHO cells heterologously expressing zebra finch CB₁cannabinoid receptors

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Cannabinoid exposure alters learning of zebra finch vocal patterns

Cited by 44 publications

References 14 publications

Developmental pattern of CB1 cannabinoid receptor immunoreactivity in brain regions important to zebra finch (Taeniopygia guttata) song learning and control

Developmental pattern of CB1 cannabinoid receptor immunoreactivity in brain regions important to zebra finch (Taeniopygia guttata) song learning and control

Long-term effects of cannabis on eye movement control in reading

Altered patterns of filopodia production in CHO cells heterologously expressing zebra finch CB1cannabinoid receptors

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Developmental pattern of CB₁ cannabinoid receptor immunoreactivity in brain regions important to zebra finch (Taeniopygia guttata) song learning and control

Developmental pattern of CB₁ cannabinoid receptor immunoreactivity in brain regions important to zebra finch (Taeniopygia guttata) song learning and control

Altered patterns of filopodia production in CHO cells heterologously expressing zebra finch CB₁cannabinoid receptors