1999
DOI: 10.1073/pnas.96.25.14565
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Cannabinoid CB1 receptors and ligands in vertebrate retina: Localization and function of an endogenous signaling system

Abstract: CB1, a cannabinoid receptor enriched in neuronal tissue, was found in high concentration in retinas of rhesus monkey, mouse, rat, chick, goldfish, and tiger salamander by using a subtype-specific polyclonal antibody. Immunolabeling was detected in the two synaptic layers of the retina, the inner and outer plexiform layers, of all six species examined. In the outer plexiform layer, CB1 was located in and͞or on cone pedicles and rod spherules. Labeling was detected in some amacrine cells of all species and in th… Show more

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Cited by 186 publications
(179 citation statements)
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“…Inhibition of LTCCs by WIN 55,212-2 has been reported also in identified retinal bipolar cells [20] and in cerebral vascular smooth muscle cells [21]. In the latter case, WIN 55,212-2 and the endocannabinoid anandamide inhibited the LTCCs in a voltage-independent manner and the effects were PTX-sensitive.…”
Section: L-type Versus Non-l-type Channel Modulation By Cannabinoidsmentioning
confidence: 76%
“…Inhibition of LTCCs by WIN 55,212-2 has been reported also in identified retinal bipolar cells [20] and in cerebral vascular smooth muscle cells [21]. In the latter case, WIN 55,212-2 and the endocannabinoid anandamide inhibited the LTCCs in a voltage-independent manner and the effects were PTX-sensitive.…”
Section: L-type Versus Non-l-type Channel Modulation By Cannabinoidsmentioning
confidence: 76%
“…RT-PCR and in situ hybridization indicate the presence of both CB1 and CB2 receptors throughout the retina (Lu et al, 2000;Buckley et al, 1998;Porcella et al, 2000). CB1 receptor antibodies label many neurons in the retina, including rod and cone terminals (Straiker et al, 1999;Yazulla et al, 1999;Straiker and Sullivan, 2003). Although the endogenous cannabinoid, anandamide, has not been detected, the CB1 agonist 2-arachidonylglycerol and CB2 agonist palmitoylethanolamide were found to be present in high levels in retina (Straiker et al, 1999).…”
Section: Cannabinoids-cannabinoidsmentioning
confidence: 99%
“…CB1 receptor antibodies label many neurons in the retina, including rod and cone terminals (Straiker et al, 1999;Yazulla et al, 1999;Straiker and Sullivan, 2003). Although the endogenous cannabinoid, anandamide, has not been detected, the CB1 agonist 2-arachidonylglycerol and CB2 agonist palmitoylethanolamide were found to be present in high levels in retina (Straiker et al, 1999). Fatty acid amide hydrolase, which hydrolyzes anandamide and 2-arachidonylglycerol, is also widespread in retina and prominently expressed in horizontal cells (Yazulla et al, 1999).…”
Section: Cannabinoids-cannabinoidsmentioning
confidence: 99%
“…Interestingly, a strikingly similar localization of CB1 was recently shown in the retina of different vertebrate species as well. 42 I. Katona et al 802 …”
Section: Similar Distribution Pattern Of Cb1 Cannabinoid Receptors Inmentioning
confidence: 99%