Cannabidiol Protects Striatal Neurons by Attenuating Endoplasmic Reticulum Stress

Patel, Vidhi; Abu-Hijleh, Fahed; Rigg, Nicolette; Mishra, Ram K.

doi:10.1089/can.2022.0090

Cited by 2 publications

(3 citation statements)

References 54 publications

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“…Additionally, CBD demonstrated the neuroprotective effect on endoplasmic reticulum stress in STHdhQ7/Q7 striatal cells. CBD pretreatment increased cell viability and the gene expression of the pro-survival chaperone GRP78 and the neurotrophic factor MANF, while decreasing the expression of pro-apoptotic markers such as BIM and caspase-12, indicating that CBD may protect against endoplasmic reticulum stress-induced cell death [87]. CBD demonstrated anti-inflammatory and antinociceptive effects in conditions induced by zymosan.…”

Section: Role Of Cannabis Compounds In Neurological and Systemic Infl...mentioning

confidence: 93%

Possible Role of Cannabis in the Management of Neuroinflammation in Patients with Post-COVID Condition

Cárdenas-Rodríguez,

Ignacio-Mejía,

Correa-Basurto

et al. 2024

IJMS

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The post-COVID condition (PCC) is a pathology stemming from COVID-19, and studying its pathophysiology, diagnosis, and treatment is crucial. Neuroinflammation causes the most common manifestations of this disease including headaches, fatigue, insomnia, depression, anxiety, among others. Currently, there are no specific management proposals; however, given that the inflammatory component involves cytokines and free radicals, these conditions must be treated to reduce the current symptoms and provide neuroprotection to reduce the risk of a long-term neurodegenerative disease. It has been shown that cannabis has compounds with immunomodulatory and antioxidant functions in other pathologies. Therefore, exploring this approach could provide a viable therapeutic option for PCC, which is the purpose of this review. This review involved an exhaustive search in specialized databases including PubMed, PubChem, ProQuest, EBSCO, Scopus, Science Direct, Web of Science, and Clinical Trials. Phytocannabinoids, including cannabidiol (CBD), cannabigerol (CBG), and Delta-9-tetrahydrocannabinol (THC), exhibit significant antioxidative and anti-inflammatory properties and have been shown to be an effective treatment for neuroinflammatory conditions. These compounds could be promising adjuvants for PCC alone or in combination with other antioxidants or therapies. PCC presents significant challenges to neurological health, and neuroinflammation and oxidative stress play central roles in its pathogenesis. Antioxidant therapy and cannabinoid-based approaches represent promising areas of research and treatment for mitigating adverse effects, but further studies are needed.

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Section: Role Of Cannabis Compounds In Neurological and Systemic Infl...mentioning

confidence: 93%

Possible Role of Cannabis in the Management of Neuroinflammation in Patients with Post-COVID Condition

Cárdenas-Rodríguez,

Ignacio-Mejía,

Correa-Basurto

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…The modulation of these quantifiable molecular markers of AD by CBD and its precursor CBDA were further translated into AD-relevant changes in cell viability in vitro, and physiological and cognitive-behavioural changes in vivo [133][134][135][136][137][138][139]141,143,144,146,[148][149][150]152,154]. Multiple investigations revealed that CBD did not display neurotoxicity at physiologically relevant doses, while also increasing the viability of SH-SY5Y cells and mouse cortical neurons and striatal-derived STHdh Q7/Q7 cells compared to cells treated only with neurotoxic compounds, such as Aβ 1-42 and t-BHP [133,134,137,141]. Patel et al also showed that STHdh Q7/Q7 cells pre-treated with CBD exhibited increased pro-survival markers of the unfolded protein response (UPR) at the mRNA and protein level, while decreasing mRNA expression of pro-apoptotic genes Bcl-2-like protein 11 (BIM) and caspase-12 [141].…”

Section: Cannabidiol As a Potential Treatment For Alzheimer's Diseasementioning

confidence: 99%

“…Multiple investigations revealed that CBD did not display neurotoxicity at physiologically relevant doses, while also increasing the viability of SH-SY5Y cells and mouse cortical neurons and striatal-derived STHdh Q7/Q7 cells compared to cells treated only with neurotoxic compounds, such as Aβ 1-42 and t-BHP [133,134,137,141]. Patel et al also showed that STHdh Q7/Q7 cells pre-treated with CBD exhibited increased pro-survival markers of the unfolded protein response (UPR) at the mRNA and protein level, while decreasing mRNA expression of pro-apoptotic genes Bcl-2-like protein 11 (BIM) and caspase-12 [141]. Although some studies reported that the treatment of rodent models of AD with CBD alone had no effect on AD-related pathologies or cognition, many reported opposite findings [147,148].…”

Section: Cannabidiol As a Potential Treatment For Alzheimer's Diseasementioning

confidence: 99%

Modulation of Oxidative Stress and Neuroinflammation by Cannabidiol (CBD): Promising Targets for the Treatment of Alzheimer’s Disease

Hickey,

Collins,

Nelson

et al. 2024

CIMB

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Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common form of dementia globally. Although the direct cause of AD remains under debate, neuroinflammation and oxidative stress are critical components in its pathogenesis and progression. As a result, compounds like cannabidiol (CBD) are being increasingly investigated for their ability to provide antioxidant and anti-inflammatory neuroprotection. CBD is the primary non-psychotropic phytocannabinoid derived from Cannabis sativa. It has been found to provide beneficial outcomes in a variety of medical conditions and is gaining increasing attention for its potential therapeutic application in AD. CBD is not psychoactive and its lipophilic nature allows its rapid distribution throughout the body, including across the blood–brain barrier (BBB). CBD also possesses anti-inflammatory, antioxidant, and neuroprotective properties, making it a viable candidate for AD treatment. This review outlines CBD’s mechanism of action, the role of oxidative stress and neuroinflammation in AD, and the effectiveness and limitations of CBD in preclinical models of AD.

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Cannabidiol Protects Striatal Neurons by Attenuating Endoplasmic Reticulum Stress

Cited by 2 publications

References 54 publications

Possible Role of Cannabis in the Management of Neuroinflammation in Patients with Post-COVID Condition

Possible Role of Cannabis in the Management of Neuroinflammation in Patients with Post-COVID Condition

Modulation of Oxidative Stress and Neuroinflammation by Cannabidiol (CBD): Promising Targets for the Treatment of Alzheimer’s Disease

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