Cannabidiol Protects Dopaminergic Neuronal Cells from Cadmium

Branca, Jacopo Junio Valerio; Morucci, Gabriele; Becatti, Matteo; Carrino, Donatello; Ghelardini, Carla; Gulisano, Massimo; Mannelli, Lorenzo Di Cesare; Pacini, Alessandra

doi:10.3390/ijerph16224420

Cited by 36 publications

(26 citation statements)

References 108 publications

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“…Another aspect to consider that could explain why Cd is counted among the etiopathogenetic factors of degenerative diseases is the Cd-dependent downregulation of growth associated protein-43 (GAP-43) and βIII-tubulin in differentiated SH-SY5Y cell line [172,173]. Since neurodegenerative disorders are associated with synaptic dysfunction [174], the downregulation of these two proteins, highly expressed in the neuronal growth cones throughout development and axonal regeneration, could explain, at least in part, why Cd intoxication could trigger signaling pathways that induce neuronal degeneration.…”

Section: Cadmium and Neuronsmentioning

confidence: 99%

“…Finally, to exacerbate the role of Cd-induced oxidative stress, a mention of the antioxidant molecules used to retrieve its detrimental effects is needed. Indeed, many molecules with well-known antioxidant properties were studied to counteract Cd-induced neural oxidative stress, such as royal jelly [175], flavonoids and polyphenols content in Fragaria ananassa methanolic extract [176], selenium [172,177], zinc [172] and CBD [173] as new emerging antioxidant tools in neurodegenerative disorders [178]. Furthermore, in order to counteract the Cd deleterious effects, some studies highlighted the role of divalent metal ions such as magnesium, calcium, zinc in competing with Cd for the same binding sites [179][180][181].…”

Section: Cadmium and Neuronsmentioning

confidence: 99%

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Cadmium-Induced Oxidative Stress: Focus on the Central Nervous System

et al. 2020

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Cadmium (Cd), a category I human carcinogen, is a well-known widespread environmental pollutant. Chronic Cd exposure affects different organs and tissues, such as the central nervous system (CNS), and its deleterious effects can be linked to indirect reactive oxygen species (ROS) generation. Since Cd is predominantly present in +2 oxidation state, it can interplay with a plethora of channels and transporters in the cell membrane surface in order to enter the cells. Mitochondrial dysfunction, ROS production, glutathione depletion and lipid peroxidation are reviewed in order to better characterize the Cd-elicited molecular pathways. Furthermore, Cd effects on different CNS cell types have been highlighted to better elucidate its role in neurodegenerative disorders. Indeed, Cd can increase blood–brain barrier (BBB) permeability and promotes Cd entry that, in turn, stimulates pericytes in maintaining the BBB open. Once inside the CNS, Cd acts on glial cells (astrocytes, microglia, oligodendrocytes) triggering a pro-inflammatory cascade that accounts for the Cd deleterious effects and neurons inducing the destruction of synaptic branches.

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Section: Cadmium and Neuronsmentioning

confidence: 99%

Section: Cadmium and Neuronsmentioning

confidence: 99%

Cadmium-Induced Oxidative Stress: Focus on the Central Nervous System

et al. 2020

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“…Indeed, once the BBB integrity is compromised, heavy metals and other toxicants can enter the CNS and activate glial cells, causing brain inflammation and neural degeneration (Branca et al, 2020). Once inside the brain parenchyma, Cd can induce mitochondrial dysfunction and subsequent cytochrome c release in neural cells (Branca et al, 2018(Branca et al, , 2019b.…”

Section: Introductionmentioning

confidence: 99%

Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain

Branca

Pacini

Gulisano

et al. 2020

Front. Cell Dev. Biol.

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Cadmium (Cd) is a well-known heavy metal and environmental toxicant and pollutant worldwide, being largely present in every kind of item such as plastic (toys), battery, paints, ceramics, contaminated water, air, soil, food, fertilizers, and cigarette smoke. Nowadays, it represents an important research area for the scientific community mainly for its effects on public health. Due to a half-life ranging between 15 and 30 years, Cd owns the ability to accumulate in organs and tissues, exerting deleterious effects. Thus, even at low doses, a Cd prolonged exposure may cause a multiorgan toxicity. Mitochondria are key intracellular targets for Cd-induced cytotoxicity, but the underlying mechanisms are not fully elucidated. The present review is aimed to clarify the effects of Cd on mitochondria and, particularly, on the mitochondrial electron transport chain.

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“…Previous reports have suggested both a potentially beneficial effect, as well as a potentially negative effect [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ], for cannabis use in the context of human disease. The food and drug administration (FDA) has approved a number of cannabis-related therapies, including synthetic THC compounds, as well as plant-derived CBD [ 23 , 24 , 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Male and Female Patients in Louisiana Medical Marijuana Dispensaries

Allen

Boudreaux²,

Keller

2020

JCM

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Relatively little is known in terms of patient demographics, indications, previous cannabis use, or the forms and dosages of medical marijuana (MM) dispensed for patients at MM dispensaries. Even less is known in terms of how male and female patients may differ in each of these aspects. The goal of the current study was to examine each of these variables using a retrospective analysis of deidentified patient data from MM dispensaries in Louisiana. Deidentified data were analyzed from web-based pharmacist–patient consultations at MM dispensaries throughout Louisiana. Data were collected during the first 6 months following the initiation of the MM dispensing program in Louisiana. A total of 1195 MM patients (598 male/597 female) were included in the analyses. The average age of the sample was 51.9 years (±14.8) and it was composed primarily of white patients (86.7%). Males and females were nearly identical in terms of average age, race, previous cannabis use, indication profile, and MM recommendations. Differences between males and females were observed in terms of opioid use, history of psychosis, presence of more than one indication, and the duration of previous cannabis use. Our data indicate that, in MM dispensaries of the Deep South state, there are numerous similarities—and some potentially important differences—between male and female MM patients. The importance of these differences, and the importance of continued data collection/analysis, for improving MM dispensing are discussed.

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Cannabidiol Protects Dopaminergic Neuronal Cells from Cadmium

Cited by 36 publications

References 108 publications

Cadmium-Induced Oxidative Stress: Focus on the Central Nervous System

Cadmium-Induced Oxidative Stress: Focus on the Central Nervous System

Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain

Comparison of Male and Female Patients in Louisiana Medical Marijuana Dispensaries

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