2008
DOI: 10.1590/s1516-44462008000300015
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Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action

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Cited by 340 publications
(340 citation statements)
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References 100 publications
(115 reference statements)
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“…Nesse cenário, o Canabidiol (CBD) vem ganhando destaque, pois um grande número de efeitos farmacológicos tem sido atribuído à molécula (SCUDERI et al, 2009), incluindo efeitos anticonvulsivantes, sedativos, ansiolíticos, antipsicóticos, anti-inflamatórias, antioxidantes e neuroprotetores, assim como efeitos sobre o sistema imunológico e circulatório (ZUARDI, 2008).…”
Section: Artigo De Revisãounclassified
“…Nesse cenário, o Canabidiol (CBD) vem ganhando destaque, pois um grande número de efeitos farmacológicos tem sido atribuído à molécula (SCUDERI et al, 2009), incluindo efeitos anticonvulsivantes, sedativos, ansiolíticos, antipsicóticos, anti-inflamatórias, antioxidantes e neuroprotetores, assim como efeitos sobre o sistema imunológico e circulatório (ZUARDI, 2008).…”
Section: Artigo De Revisãounclassified
“…The CB2 receptor is a G-coupled protein receptor located predominantly in immune cells whose distribution and functions coincide closely with many observed immune effects of CBD (Ligresti, De Petrocellis, & Di Marzo, 2016). Despite hundreds of scientific articles written about CBD in recent times (Burstein, 2015;Zuardi, 2008), published displacement values (Ki) for the CBD/CB2 interaction continue to vary substantially. Inconsistent results such as these make dosage recommendations impossible (Thomas, 2017).…”
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confidence: 99%
“…In one of such interaction studies involving healthy volunteers, CBD was shown to attenuate the anxiety and psychotomimetic actions of elevated doses of ∆ 9 -THC, suggesting that CBD could have anxiolytic and/or antipsychotic properties. That was the beginning of a line of investigation followed by our research group until today 4 and that is described in the article entitled Therapeutical use of cannabinoids in psychiatry, included in this supplement. 5 The contradictory actions of cannabinoids on mental disorders are discussed in this supplement by two other articles, one dealing with the effects of cannabinoids in psychoses and the other with the abuse of cannabis by patients with mental disorders.…”
mentioning
confidence: 99%