2019
DOI: 10.1176/appi.ajp.2019.18101191
|View full text |Cite|
|
Sign up to set email alerts
|

Cannabidiol for the Reduction of Cue-Induced Craving and Anxiety in Drug-Abstinent Individuals With Heroin Use Disorder: A Double-Blind Randomized Placebo-Controlled Trial

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

3
172
1
5

Year Published

2019
2019
2022
2022

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 247 publications
(198 citation statements)
references
References 37 publications
3
172
1
5
Order By: Relevance
“…The results of this study suggest that using CBD-rich hemp extract oil may help reduce opioid use and improve quality of life, specifically in regards to pain and sleep, among chronic pain patients. This is consistent with emerging literature on the topic, which has concluded that CBD is an effective analgesic, and one that helps reduce barriers to opioid reduction, such as physiological withdrawal symptoms [22][23][24][25][26][27][28][29][30][31]. Recently, Wiese et al summarized the evidence for different used of the cannabinoids with opioids [13].…”
Section: Discussionsupporting
confidence: 78%
See 1 more Smart Citation
“…The results of this study suggest that using CBD-rich hemp extract oil may help reduce opioid use and improve quality of life, specifically in regards to pain and sleep, among chronic pain patients. This is consistent with emerging literature on the topic, which has concluded that CBD is an effective analgesic, and one that helps reduce barriers to opioid reduction, such as physiological withdrawal symptoms [22][23][24][25][26][27][28][29][30][31]. Recently, Wiese et al summarized the evidence for different used of the cannabinoids with opioids [13].…”
Section: Discussionsupporting
confidence: 78%
“…A recent survey study concluded that 44% of hemp CBD users reported it helped reduce the use of their opioid pain medication [25]. CBD was found to reduce the craving, anxiety and psychological manifestations significantly in drug-abstinent individuals with previous opioid dependency [26,27]. Emerging literature supports evidence for CBD in pain relief and opioid reduction, but no studies to date have evaluated the effects of readily available hemp CBD in chronic pain and opioid use in a single cohort.…”
Section: Introductionmentioning
confidence: 99%
“…9,10 Recent experimental trials in humans have shown that lower doses of opioids co-administered with cannabinoids achieved analgesia equivalent to higher doses of opioids, 11 and administration of cannabidiol reduced cue-induced opioid craving among people with opioid use disorder. 12 In our 3 prospective cohorts of people at high risk of opioid overdose in Vancouver, we have found a number of beneficial long itudinal associations with consistent cannabis use, such as superior engagement in opioid agonist therapies for opioid use disorder, 13 reduced frequency of illicit opioid use in the context of chronic pain 14 and lower rates of exposure to fentanyl. 15 We strongly agree with the authors' views that governments, regulators and other stakeholders must support highquality independent research into cannabis in order to mitigate its harms and maximize its potential benefits.…”
Section: Evidence Shows That Cannabis Has Fewer Relative Harms Than Omentioning
confidence: 96%
“…Cannabidiol (CBD), the most abundant non-psychotropic constituent of the Cannabis sativa plant, has drawn the attention of scientific community due to its putative desirable effects for the treatment of various psychiatric diseases (Devinsky et al, 2014), including drug addiction (Zlebnik and Cheer, 2016). CBD has been shown able to reduce the behavioural and molecular manifestations of maladaptive neuroplasticity underlying drug addiction (Hurd et al, 2019). However, available evidence supporting a 5 protective role of CBD in pre-clinical models of volitional drug seeking, and its mode of action, is still scarce.…”
Section: Introductionmentioning
confidence: 99%