Cannabidiol attenuated the maintenance and reinstatement of extinguished methylphenidate-induced conditioned place preference in rats

Kashefi, Adel; Tomaz, Carlos; Jamali, Shole; Rashidy-Pour, Ali; Vafaei, Abbas Ali; Haghparast, Abbas

doi:10.1016/j.brainresbull.2020.11.021

Cited by 13 publications

(1 citation statement)

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“…The time spent in each compartment was measured by analyzing the recordings obtained by internet protocol cameras (LX-C202 model; Lynx Security, China) fixed above each place preference apparatus and wireless connected to a computer in another room. During the conditioning period (5 days), the non-preferred compartment (the white side) was associated with reward induced by MPH injection at a dose of 5 mg/kg i. p., once per day, which was previously stablished elsewhere ( Kashefi et al, 2021 ). The preferred compartment (black side), as well as the animals that did not receive drug during the conditioning period, were paired with a 1 ml/kg saline i. p. injection.…”

Section: Methodsmentioning

confidence: 99%

Early-Life Exposure to Non-Absorbable Broad-Spectrum Antibiotics Affects the Dopamine Mesocorticolimbic Pathway of Adult Rats in a Sex-Dependent Manner

González-Arancibia

Collio²,

Silva-Olivares³

et al. 2022

Front. Pharmacol.

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Gut microbiota with a stable, rich, and diverse composition is associated with adequate postnatal brain development. Colonization of the infant’s gut begins at birth when parturition exposes the newborn to a set of maternal bacteria, increasing richness and diversity until one to two first years of age when a microbiota composition is stable until old age. Conversely, alterations in gut microbiota by diet, stress, infection, and antibiotic exposure have been associated with several pathologies, including metabolic and neuropsychiatric diseases such as obesity, anxiety, depression, and drug addiction, among others. However, the consequences of early-life exposure to antibiotics (ELEA) on the dopamine (DA) mesocorticolimbic circuit are poorly studied. In this context, we administered oral non-absorbable broad-spectrum antibiotics to pregnant Sprague-Dawley dams during the perinatal period (from embryonic day 18 until postnatal day 7) and investigated their adult offspring (postnatal day 60) to assess methylphenidate-induced conditioned place preference (CPP) and locomotor activity, DA release, DA and 3,4-dihydroxyphenylacetic acid (DOPAC) content in ventral tegmental area (VTA), and expression of key proteins within the mesocorticolimbic system. Our results show that ELEA affect the rats conduct by increasing drug-seeking behavior and locomotor activity induced by methylphenidate of males and females, respectively, while reducing dopamine striatal release and VTA content of DOPAC in females. In addition, antibiotics increased protein levels of DA type 1 receptor in prefrontal cortex and VTA of female rats, and tyrosine hydroxylase in VTA of adult male and female rats. Altogether, these results suggest that ELEA alters the development of the microbiota-gut-brain axis affecting the reward system and the response to abuse drugs in adulthood.

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Section: Methodsmentioning

confidence: 99%