Cannabidiol: A budding industry!

Steenson, Simon; Chambers, L.

doi:10.1111/nbu.12395

Cited by 6 publications

(10 citation statements)

References 62 publications

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“…Many of them have been developed to be marketed as medicinal products [2,3] or as cosmetics. Indeed, several skincare products have also been placed on the market, relying on CBD claimed anti-seborrheic, anti-aging, antioxidant, and skin-protective properties [13,14].…”

Section: Introductionmentioning

confidence: 99%

Topical Administration of Cannabidiol: Influence of Vehicle-Related Aspects on Skin Permeation Process

et al. 2020

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Cannabidiol (CBD) is a non-psychoactive cannabinoid isolated from Cannabis sativa which, given its claimed beneficial properties and therapeutic potential, has lately aroused considerable attention from the scientific community. Starting from the little literature evidence, the main purpose of this study was to investigate the topical administration of CBD, with particular focus on the influence of vehicle-related aspects on the skin permeation process. This could provide useful information for the design of suitable drug delivery systems which could be used in developing topical medicines and cosmetics. In vitro human skin permeation studies were conducted using modified Franz diffusion cells to compare the performance of four solutions and two semisolid formulations. The Hildebrand solubility parameter was used to better understand the thermodynamic aspects implied in the partitioning process of the cannabinoid compound into the skin. It was interestingly found that a hydrophilic gel, mostly consisting of propylene glycol (79%, w/w), can be an optimal choice for the topical administration of CBD. Moreover, the feasibility of the preparation of CBD-loaded (trans)dermal patches, made with new printing technology, was also demonstrated.

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Section: Introductionmentioning

confidence: 99%

Topical Administration of Cannabidiol: Influence of Vehicle-Related Aspects on Skin Permeation Process

et al. 2020

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“…Cannabis originates from the plant C. sativa, of which C. indica and C. ruderalis are subspecies. [2,[30][31][32] Cannabis contains cannabinoids, [33] such as cannabidiol (CBD), Δ 9 -tetrahydrocannabinol (Δ 9 -THC), cannabinol (CBN) and tetrahydrocannabivarin (THCV), of which the last three are psychoactive. [2] Most of the psychotropic effects are caused by Δ 9 -THC.…”

Section: Composition Of Cannabis Plant Extractmentioning

confidence: 99%

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confidence: 99%

The implications of the use of cannabidiol-related products in a safety-sensitive drug testing environment: A medical-legal perspective

Jooste

Laurens²,

Jordaan³

et al. 2021

S Afr Med J

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Cannabis sativa L. was brought to Africa by Arab traders, and has been cultivated for at least 5 000 years for many established medical and historical purposes. [1][2][3] Marijuana and hemp are colloquial names for cannabis strains of the same plant genus. Hemp is characterised by a low concentration of delta-9-tetrahydrocannabinol (Δ 9 -THC), the primary psychoactive compound in C. sativa, popularising hemp cannabidiol (CBD) oils, as the medical benefits can be obtained without the psychoactive effect of marijuana, the latter characterised by high concentrations of Δ 9 -THC.CBD demonstrates a decreased agonism of the CB-1 receptor compared with Δ 9 -THC, explaining the absence of psychoactive effects. [4] It is claimed that CBD can reduce the use of opioids owing to its antinociceptive effects in inflammation models, reducing heroin-seeking behaviour. [5][6][7][8] After numerous calls for legalisation from the South African (SA) public and activists, despite some caution raised by academics, [9,10] C. sativa access laws were passed, first by legalising the private use of cannabis, [11][12][13][14] and secondly, by amendments to the schedules of the Medicines and Related Substances Act No. 101 of 1965 (Medicines Act), [15] applying a threshold concentration approach for CBD and Δ 9 -THC.As with all crucial decisions, unforeseen consequences have created dilemmas. One of these is that hemp products and CBD oils are contaminated with Δ 9 -THC owing to unregulated cannabis plant strains, ineffective enrichment and purification procedures, inadequate analytical quality control and testing and known law enforcement constraints to ensure product compliance in SA. These factors were legitimate concerns before legalisation, and have This open-access article is distributed under Creative Commons licence CC-BY-NC 4.0.

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“…While Delta-9-THC-containing cannabis products remain illegal at the federal level in the United States, the passage of the 2018 Farm Bill provided a legal justification for the manufacturing and sale of “CBD Products” (those containing hemp-derived CBD and ≤0.3% Delta-9-THC) in all 50 US states [ 1 ]. Since this time, CBD products have become incredibly popular and so diverse that they can be incorporated into almost every aspect of a consumer’s lifestyle, including bath soaps, candy, cosmetics, drink mixers or tincture, food, medicinal products (e.g., pain pills or sleep aids), pet products, sex lubricants, cigarettes, and vaporizers [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Availability and Promotion of Cannabidiol (CBD) Products in Online Vape Shops

Leas

Moy

McMenamin

et al. 2021

IJERPH

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Vaping products containing cannabidiol (CBD), a cannabis-derived compound used in wellness products and available in all 50 US states, were recently implicated in outbreaks of poisonings. Little is known about the commercial availability of CBD products in vape shops (i.e., stores that sell e-cigarettes). To document the availability and marketing of CBD products in online vape shops, in June 2020, we used the Google Chrome browser without cached data to collect the first two pages of search results generated by five Google queries (n = 100 search results) indicative of shopping for vaping products (e.g., “order vapes”). We then determined whether and what type of CBD products could be mail-ordered from the returned websites, and whether any explicit health claims were made about CBD. Over a third of the search results (n = 37; 37.0%) directed to vape shops that allowed visitors to also mail-order CBD. These shops sold 12 distinct categories of CBD products–some with direct analogs of tobacco or cannabis products including CBD cigarettes, edibles, flowers, pre-rolled joints, and vapes. Two vape shops made explicit health claims of the therapeutic benefits of CBD use, including in the treatment of anxiety, inflammation, pain, and stress. The abundance and placement of CBD in online vape shops suggests a growing demand and appeal for CBD products among e-cigarette users. Additional surveillance on the epidemiology of CBD use and its co-use with tobacco is warranted.

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Cannabidiol: A budding industry!

Cited by 6 publications

References 62 publications

Topical Administration of Cannabidiol: Influence of Vehicle-Related Aspects on Skin Permeation Process

Topical Administration of Cannabidiol: Influence of Vehicle-Related Aspects on Skin Permeation Process

The implications of the use of cannabidiol-related products in a safety-sensitive drug testing environment: A medical-legal perspective

Availability and Promotion of Cannabidiol (CBD) Products in Online Vape Shops

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