Canine Systemic Lupus Erythematosus. II: Antinuclear Antibodies

Monier, J. C.; Ritter, J; Caux, C.; Chabanne, Luc; Fournel, C.; Venet, C.; Rigali, D.

doi:10.1177/0961203392001005031

Cited by 35 publications

(33 citation statements)

References 21 publications

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“…7,8 Several of the nuclear antigens that constitute a target for disease-associated ANAs have been characterized. 6,11,12 Some of these specific ANA targets have been demonstrated in humans to strongly associate with different systemic autoimmune diseases. Different ANA specificities also are associated with different IIF-ANA staining patterns.…”

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confidence: 99%

Subgroups of canine antinuclear antibodies in relation to laboratory and clinical findings in immune‐mediated disease

Hansson-Hamlin¹,

Lilliehöök²,

Trowald-Wigh³

2006

Veterinary Clinical Pathol

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In dogs with homogeneous IIF-ANA staining, SLE is a probable diagnosis because of the diversity of clinical manifestations and autoantibody reactivity against chromosomal antigens. Dogs with a speckled IIF-ANA pattern may have SLE-related diseases, which, in turn, may be correlated with different immunodiffusion subgroups. These syndromes had overlapping clinicopathologic features, as described for human patients.

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confidence: 99%

Subgroups of canine antinuclear antibodies in relation to laboratory and clinical findings in immune‐mediated disease

Hansson-Hamlin¹,

Lilliehöök²,

Trowald-Wigh³

2006

Veterinary Clinical Pathol

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“…The high prevalence of anti-H3 antibodies in sera of VL dogs indicates that the H3 protein has potential usefulness as a tool for serodiagnosis of leishmaniasis. The use of the complete H3 recombinant protein for serodiagnosis of VL could have serious drawbacks because of its potential cross-reactivity with sera from animals having other diseases where anti-histone antibodies are induced, as, for example, canine SLE [36,37]. Since anti-H3 antibodies in SLE dogs are essentially directed against the globular region of H3, the cross-reactivity problem can be circumvented if the amino-terminal region of the histone H3 is used instead of the complete protein.…”

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confidence: 99%

Characterization of the antigenic determinants of the Leishmania infantum histone H3 recognized by antibodies elicited during canine visceral leishmaniasis

Soto

Requena

Quijada

et al. 1996

Clinical and Experimental Immunology

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SUMMARYIn the present study we show that sera from dogs naturally infected with the protozoan parasite Leishmania infantum contain antibodies that specifically react with the parasite histone H3. Using synthetic peptides covering the complete sequence of the protein we located the linear antigenic determinants within the 40 amino-terminal amino acids of the molecule. In addition to the complete form of the protein (rLiH3), two regions of the Leishmania histone H3 were expressed as recombinant proteins: the rLiH3-Nt fragment containing the 39 amino-terminal amino acids and the rLiH3-Ct fragment containing the 90 carboxyl-terminal residues. Competition experiments using the protein fragment rLiH3-Nt as competitor confirmed that the antigenic determinants of histone H3 are confined to the amino-terminal domain. This domain, which is believed to be exposed on the nucleosome surface, is also the most evolutionarily divergent region of the L. infantum histone H3. Visceral leishmaniasis (VL) sera do not react with mammalian histones, an indication that the anti-histone response elicited during Leishmania infection is triggered by the parasite histone. The results of the prevalence of antihistone H3 antibodies in canine VL sera together with the sequence-specific characteristics of the amino-terminal region of L. infantum histone H3 indicate that the recombinant protein rLiH3-Nt may be of use for diagnosis of canine VL.

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“…Of interest, HMG-14 and HMG-17 bind to the core histones and are preferentially associated with transcriptionally active chromatin (3), whereas HMG-1 and HMG-2 are associated with internucleosomal DNA (2). HMG antibodies have been found in patients with systemic lupus erythematosus (SLE) (4) and juvenile rheumatoid arthritis (JRA) (5,6), and in canine lupus (7). There have been no published studies to date of HMG antibodies in drug-induced lupus (DIL).…”

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Antibodies to Hmg Proteins in Patients with Drug‐Induced Autoimmunity

Ayer

Rubin

Dixon

et al. 1994

Arthritis & Rheumatism

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Objective. To determine the prevalence of autoantibodies to high-mobility group (HMG) proteins in sera from patients with drug-induced lupus (DIL).Methods. Forty-two patients who developed autoantibodies andor lupus after treatment with procainamide or other drugs were tested for HMG autoantibodies by immunoblotting and enzyme-linked immunosorbent assay (ELISA).Results. Twenty-eight of the 42 sera (67%) bound HMG-14 andor HMG-17. In comparison, 9 of 42 (21%) bound HMG-1 and/or HMG-2. There was a good correlation between ELISA results and binding on immunoblots.Conclusion. The high prevalence of antibodies to the nucleosomal core HMGs (HMG-14 and HMG-17) in DIL patients adds evidence implicating nucleosomes as immunogens in drug-induced autoimmunity.

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Canine Systemic Lupus Erythematosus. II: Antinuclear Antibodies

Cited by 35 publications

References 21 publications

Subgroups of canine antinuclear antibodies in relation to laboratory and clinical findings in immune‐mediated disease

Subgroups of canine antinuclear antibodies in relation to laboratory and clinical findings in immune‐mediated disease

Characterization of the antigenic determinants of the Leishmania infantum histone H3 recognized by antibodies elicited during canine visceral leishmaniasis

Antibodies to Hmg Proteins in Patients with Drug‐Induced Autoimmunity

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