Canine spinal nephroblastoma

Macri, Nicholas P.; Alstine, William Van; Coolman, R A

doi:10.5326/15473317-33-4-302

Cited by 21 publications

(35 citation statements)

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“…The general histological features of the neoplasm in the case reported here are in accordance with previous reports 6,10,11 , although the relatively high mitotic index of the epithelial component of the neoplasm differed from a previous series of 12 cases, in which mitoses were considered to be uncommon in glandular areas 11 . Most cases of spinal nephroblastoma have been associated with acute to subacute onset of pelvic limb paresis and loss of conscious proprioception 3,8,12 , but the onset of paresis can be more gradual 7 , as in the case reported here. As in other case reports, myelography was successful in demonstrating the lesion.…”

Section: Discussionmentioning

confidence: 55%

“…Spinal nephroblastoma is usually diagnosed in dogs between 6 months and 3 years of age 4,[7][8][9][10][11][12] , but has been reported in a 7-year-old dog 3 . It is most commonly seen in medium to large-breed dogs, with one study indicating a possibly higher incidence in German shepherd dogs 11 .…”

Section: Discussionmentioning

confidence: 99%

“…This has not previously been reported in spinal nephroblastoma and illustrates the usefulness of collecting CSF downstream from a suspected lesion, as opposed to cervical cisternal CSF collection, which, in other cases, failed to demonstrate neoplastic cells 11 . Unlike renal nephroblastoma 13 , the spinal form is not invasive and does not metastasise 7,11 , but requires rapid intervention owing to its location. Surgical removal may be beneficial if performed before severe cord compression occurs 1,3,7 .…”

Section: Discussionmentioning

confidence: 99%

“…Unlike renal nephroblastoma 13 , the spinal form is not invasive and does not metastasise 7,11 , but requires rapid intervention owing to its location. Surgical removal may be beneficial if performed before severe cord compression occurs 1,3,7 . Some animals show dramatic improvement after surgery, but this is often short-lived owing to tumour recurrence at the original site 5,8,11 .…”

Section: Discussionmentioning

confidence: 99%

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Spinal nephroblastoma in an Irish wolfhound : case report

Vaughan-Scott¹,

Goldin²,

Jw³

1999

J. S. Afr. Vet. Assoc.

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A 1-year-old Irish wolfhound was presented with a history of slowly progressive left pelvic limb paresis. A neurological examination demonstrated bilateral deficits referable to the thoracolumbar spinal cord. Lumbar cerebrospinal fluid contained neoplastic cells. An intradural, extramedullary mass was demonstrated by myelography at the caudal aspect of T13. Surgical excision was abandoned owing to severe macroscopic damage to, and apparent infiltration of, the cord, and the dog was euthanased. The tumour was diagnosed histologically as an extrarenal nephroblastoma. Nephroblastoma should be suspected in young, large-breed dogs with intradural extramedullary masses over spinal segments T10-L2. The prognosis for complete recovery after surgical excision is guarded to poor.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Spinal nephroblastoma in an Irish wolfhound : case report

Vaughan-Scott¹,

Goldin²,

Jw³

1999

J. S. Afr. Vet. Assoc.

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“…2,4,9 Clinical signs associated with spinal cord nephroblastoma are due to compression of the spinal cord by a solitary, intradural extramedullary mass, which is consistently located between the 10th thoracic (T10) and second lumbar (L2) spinal cord segments. 2, 3 The histologic appearance and immunohistochemical staining characteristics of these tumors suggest that spinal cord nephroblastomas originate from ectopic metanephric blastema.…”

Section: Brief Communications and Case Reportsmentioning

confidence: 99%

Possible Intraspinal Metastasis of a Canine Spinal Cord Nephroblastoma

Terrell

Platt²,

Chrisman³

et al. 2000

Vet Pathol

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Abstract.A 2-year-old Basset Hound was admitted to the University of Florida Veterinary Medical Teaching Hospital with progressive spastic paraparesis. At necropsy, intradural extramedullary tumors produced areas of spinal cord swelling and softening in spinal cord segments T11-T12 and L4-L6. Histologic examination of the masses revealed sheets of polygonal blastemal cells, epithelial cells forming tubules and rosettes, and embryonal glomeruloid-like structures in the thoracic mass. Cells in the lumbar mass were less differentiated, forming rare tubules and no glomeruloid-like structures. The occurrence of two tumors in the spinal cord along with the less differentiated appearance of the lumbar tumor raises the possibility that the lumbar mass arose as a result of intraspinal metastasis. To our knowledge, this is the first report of multifocal or metastatic canine spinal nephroblastoma. In addition, the vimentin and cytokeratin immunohistochemical staining characteristics of these spinal cord nephroblastomas are described.

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Extrarenal nephroblastomas in the inguinal region and paraspinal musculature with vertebral involvement and spinal cord compression in a 12‐year‐old dog

Soler,

Pérez‐Hernández,

Buendía

et al. 2024

Vet Record Case Reports

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A 12‐year‐old, entire, male shar‐pei was presented with a 1‐month history of depression, lumbar pain and progressive hindlimb weakness. In addition, the owners had noticed a mass in the right inguinal region. Computed tomography showed a contrast‐enhanced soft tissue mass located at the right paraspinal musculature, affecting the vertebral body of T13, invading the vertebral canal and compressing the spinal cord. The inguinal mass showed similar imaging characteristics. Due to the uncertain prognosis, euthanasia was recommended, and postmortem examination was requested. Microscopic and immunohistochemical findings were consistent with ectopic nephroblastomas. According to this case report, ectopic nephroblastomas should be considered within the differential diagnosis of masses affecting the paraspinal musculature, as well as the inguinal region, even in senior dogs. To the authors’ knowledge, this is the first report of two ectopic nephroblastomas presented in different locations in a dog.

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Canine spinal nephroblastoma

Cited by 21 publications

References 0 publications

Spinal nephroblastoma in an Irish wolfhound : case report

Spinal nephroblastoma in an Irish wolfhound : case report

Possible Intraspinal Metastasis of a Canine Spinal Cord Nephroblastoma

Extrarenal nephroblastomas in the inguinal region and paraspinal musculature with vertebral involvement and spinal cord compression in a 12‐year‐old dog

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