Canine periodontitis: The dog as an important model for periodontal studies

Albuquerque, Carlos; Morinha, Francisco; Requicha, João Filipe; Martins, Teresa; Dias, Isabel; Guedes-Pinto, Henrique; Bastos, Estela; Viegas, Carlos

doi:10.1016/j.tvjl.2011.08.017

Cited by 103 publications

(145 citation statements)

References 60 publications

Supporting

Mentioning

139

Contrasting

Unclassified

Order By: Relevance

“…The most prevalent disorders identified in dogs within the current study were complex disorders that have multiple interacting environmental and genetic casual factors [90]: otitis externa [91], periodontal disease [92], anal sac disorders [93], nail disorders [94], [95], degenerative joint disease [96], diarrhoea [97], [98], obesity [99], traumatic injury [100], conjunctivitis [101], vomiting [101], [102] and heart murmur [103], [104]. It may be useful for canine health research to move away from viewing individual disorders as necessarily either inherited or non-inherited [105] and towards an acknowledgement of relevant roles for both genetic and environmental components in the majority of canine disorders [106], [107], [108].…”

Section: Discussionmentioning

confidence: 90%

Prevalence of Disorders Recorded in Dogs Attending Primary-Care Veterinary Practices in England

et al. 2014

View full text Add to dashboard Cite

Purebred dog health is thought to be compromised by an increasing occurence of inherited diseases but inadequate prevalence data on common disorders have hampered efforts to prioritise health reforms. Analysis of primary veterinary practice clinical data has been proposed for reliable estimation of disorder prevalence in dogs. Electronic patient record (EPR) data were collected on 148,741 dogs attending 93 clinics across central and south-eastern England. Analysis in detail of a random sample of EPRs relating to 3,884 dogs from 89 clinics identified the most frequently recorded disorders as otitis externa (prevalence 10.2%, 95% CI: 9.1–11.3), periodontal disease (9.3%, 95% CI: 8.3–10.3) and anal sac impaction (7.1%, 95% CI: 6.1–8.1). Using syndromic classification, the most prevalent body location affected was the head-and-neck (32.8%, 95% CI: 30.7–34.9), the most prevalent organ system affected was the integument (36.3%, 95% CI: 33.9–38.6) and the most prevalent pathophysiologic process diagnosed was inflammation (32.1%, 95% CI: 29.8–34.3). Among the twenty most-frequently recorded disorders, purebred dogs had a significantly higher prevalence compared with crossbreds for three: otitis externa (P = 0.001), obesity (P = 0.006) and skin mass lesion (P = 0.033), and popular breeds differed significantly from each other in their prevalence for five: periodontal disease (P = 0.002), overgrown nails (P = 0.004), degenerative joint disease (P = 0.005), obesity (P = 0.001) and lipoma (P = 0.003). These results fill a crucial data gap in disorder prevalence information and assist with disorder prioritisation. The results suggest that, for maximal impact, breeding reforms should target commonly-diagnosed complex disorders that are amenable to genetic improvement and should place special focus on at-risk breeds. Future studies evaluating disorder severity and duration will augment the usefulness of the disorder prevalence information reported herein.

show abstract

Section: Discussionmentioning

confidence: 90%

Prevalence of Disorders Recorded in Dogs Attending Primary-Care Veterinary Practices in England

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The principles of dental examination, diagnosis and treatment in carnivores are identical to those commonly performed in companion animal species, the model species being the domestic dog 8. The first line of non-surgical treatment for dental disease in carnivore species is subgingival and supragingival scaling (manual or mechanical), polishing, and sulcular lavage under general anaesthesia 9.…”

Section: Discussionmentioning

confidence: 99%

Root canal treatments and crown lengthening in an adult jaguar (Panthera onca)

O'Sullivan

Ruiz

Toosy

et al. 2019

Vet Record Case Reports

View full text Add to dashboard Cite

Pathological dental conditions in zoo animals are frequently encountered, although under-reported in the veterinary literature. Teeth fractures are commonly encountered in carnivores and often require specialised endodontic intervention. This paper describes gingivectomy of a peripheral odontogenic fibroma of the left maxillary gingivae; crown lengthening of the left mandibular canine; and pulpectomies of complicated crown fractures of the left maxillary canine tooth (204), left mandibular canine tooth (304) and left third maxillary incisor (203) in an adult jaguar (Panthera onca). Follow-on dental examination at 18 months and postoperative radiographs at 24 months found no evidence of further dental pathology. Dental examination and prophylaxis are essential components of the examination procedure. There are limited opportunities to make routine clinical assessments in zoo animals. The availability of specialised materials, equipment and specialised veterinary assistance are limitations as relevant to zoological dentistry today as when described by Fowler in 1986.

show abstract

“…Several factors make companion dogs a powerful animal model for understanding age-related diseases, including their accelerated rates of aging (compared to people), their unique genetic architecture, and the wealth of clinical veterinary knowledge and expertise . In addition, companion dogs display a high prevalence of oral diseases (Albuquerque et al, 2012), which makes them a suitable model to study the relationship between oral health and aging. It is additionally worth noting that while dogs and mice are approximately equally evolutionarily distant from humans, companion dogs share many aspects of the human environment.…”

Section: Use Of Animal Modelsmentioning

confidence: 99%

Oral health in geroscience: animal models and the aging oral cavity

Darveau

Kaeberlein

2017

GeroScience

View full text Add to dashboard Cite

Age is the single greatest risk factor for many diseases, including oral diseases. Despite this, a majority of preclinical oral health research has not adequately considered the importance of aging in research aimed at the mechanistic understanding of oral disease. Here, we have attempted to provide insights from animal studies in the geroscience field and apply them in the context of oral health research. In particular, we discuss the relationship between the biology of aging and mechanisms of oral disease. We also present a framework for defining and utilizing age-appropriate rodents and present experimental design considerations, such as the number of age-points used and the importance of genetic background. While focused primarily on rodent models, alternative animal models that may be particularly useful for studies of oral health during aging, such as companion dogs and marmoset monkeys, are also discussed. We hope that such information will aid in the design of future preclinical studies of geriatric dental health, thus allowing more reliability for translation of such studies to age-associated oral disease in people.

show abstract

Canine periodontitis: The dog as an important model for periodontal studies

Cited by 103 publications

References 60 publications

Prevalence of Disorders Recorded in Dogs Attending Primary-Care Veterinary Practices in England

Prevalence of Disorders Recorded in Dogs Attending Primary-Care Veterinary Practices in England

Root canal treatments and crown lengthening in an adult jaguar (Panthera onca)

Oral health in geroscience: animal models and the aging oral cavity

Contact Info

Product

Resources

About