Canine Oral Papillomavirus Genomic Sequence: A Unique 1.5-kb Intervening Sequence between the E2 and L2 Open Reading Frames

Delius, Hajo; Ranst, Marc Van; Jenson, A. Bennett; Hausen, H. zur; Sundberg, John P.

doi:10.1006/viro.1994.1552

Cited by 67 publications

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“…A similar NCR2 has previously only been characterized in COPV (Delius et al, 1994) and FdPV-1 (Tachezy et al, 2002a), both also belonging to the genus Lambda, and DPV, which belongs to the genus Delta (Groff & Lancaster, 1985). It is tempting to speculate that the presence of an NCR2 is a common feature of all Lambda PVs, and that the NCR2 of all three Lambda PVs could originate from a DNA sequence (of unknown function and origin) that was incorporated in their common ancestor.…”

mentioning

confidence: 55%

“…In 1994, the genomic sequence of the canine oral PV (COPV), associated with oropharyngeal papillomatosis in dogs, coyotes and wolves, was characterized (Delius et al, 1994). COPV is the largest of all known PV genomes, and contains a unique second non-coding region (NCR2) between the early and late protein region.…”

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confidence: 99%

“…NC_001619), deer DPV (8374 bp; NC_001523) and FdPV-1 (8300 bp; AF480454), all of which contain two non-coding regions (Delius et al, 1994;Groff & Lancaster, 1985;Tachezy et al, 2002a). PlPV-1 contains the seven classical PV major ORFs, encoding five early (E) proteins E1, E2, E4, E6 and E7, and two late (L) capsid proteins L1 and L2.…”

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confidence: 99%

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Isolation and cloning of the raccoon (Procyon lotor) papillomavirus type 1 by using degenerate papillomavirus-specific primers

Rector

Doorslaer

Bertelsen

et al. 2005

Journal of General Virology

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Partial sequences of a novel papillomavirus were amplified from a cutaneous lesion biopsy of a raccoon (Procyon lotor), by using PCR with degenerate papillomavirus-specific primers. The Procyon lotor papillomavirus type 1 (PlPV-1) DNA was amplified with long template PCR in two overlapping fragments, together encompassing the entire genome, and the complete PlPV-1 genomic sequence was determined. The PlPV-1 genome consists of 8170 bp, and contains the typical papillomaviral open reading frames, encoding five early proteins and two late capsid proteins. Besides the classical non-coding region (NCR1) between the end of L1 and the start of E6, PlPV-1 contains an additional non-coding region (NCR2) of 1065 bp between the early and late protein region, which has previously also been described for the canine oral papillomavirus (COPV) and the Felis domesticus papillomavirus (FdPV-1). Phylogenetic analysis places PlPV-1 together with COPV and FdPV-1 in a monophyletic branch which encompasses the Lambda papillomavirus genus.The Papillomaviridae are a large family of species-specific viruses that cause proliferations of the stratified squamous epithelium of the skin or the mucosa in a wide variety of host species (Sundberg et al., 2001). Over 90 human papillomavirus (HPV) types have been completely sequenced (de Villiers et al., 2004), and these cause a wide spectrum of genotype-specific lesions (Van Ranst et al., 1992). Only a limited number of non-human PV genotypes have been fully genetically characterized so far (Sundberg et al., 1997(Sundberg et al., , 2001de Villiers et al., 2004), but these cover a broad range of host species, and it is likely that most mammalian and avian species carry their own set of species-specific PV types.Papillomatosis has been documented in a number of carnivores, mainly Canidae and Felidae (Sundberg, 1987;Sundberg et al., 2000). In 1994, the genomic sequence of the canine oral PV (COPV), associated with oropharyngeal papillomatosis in dogs, coyotes and wolves, was characterized (Delius et al., 1994). COPV is the largest of all known PV genomes, and contains a unique second non-coding region (NCR2) between the early and late protein region. Recently, a second carnivore PV genome, containing a similar NCR2, was isolated from a cutaneous lesion of a Persian cat (Felis domesticus PV type 1, FdPV-1) (Tachezy et al., 2002a). COPV and FdPV-1 share a high degree of sequence similarity, and belong to the genus Lambda PV.Papillomavirus infection has been reported in raccoons (Procyon lotor), small carnivores that are widely distributed throughout North America. In one study, 2 of 53 wild trapped raccoons showed proliferative skin lesions that stained positive for PV group-specific antigens (Hamir et al., 1995). Since dogs and raccoons both belong to the suborder Caniformia of the Carnivora, investigation of the relationship between the canine COPV and the raccoon PV would be interesting to test the hypothesis that PVs have co-evolved with their host species.We report here the complete genomic seq...

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Isolation and cloning of the raccoon (Procyon lotor) papillomavirus type 1 by using degenerate papillomavirus-specific primers

Rector

Doorslaer

Bertelsen

et al. 2005

Journal of General Virology

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“…HPV57 DNA was originally described as HPV2 (23). The HPV8 (28), HPV31 (29,30), COPV (31), and ROPV (32) genomes were obtained from T. Iftner (University of Tübingen, Tübingen, Germany), L. Laimins (Northwestern University, Chicago), R. Schlegel (Georgetown University, Washington, DC), and N. Christensen (Pennsylvania State University, Hershey, PA), respectively. Recircularization of HPV1a, HPV4, HPV31, HPV57, and DPV genomes was necessary because they were cloned in the E2 gene.…”

Section: Methodsmentioning

confidence: 99%

Variations in the association of papillomavirus E2 proteins with mitotic chromosomes

Oliveira

Colf

McBride

2006

Proc. Natl. Acad. Sci. U.S.A.

100

145

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The E2 protein segregates episomal bovine papillomavirus (BPV) genomes to daughter cells by tethering them to mitotic chromosomes, thus ensuring equal distribution and retention of viral DNA. To date, only the BPV1 E2 protein has been shown to bind to mitotic chromosomes. We assessed the localization of 13 different animal and human E2 proteins from seven papillomavirus genera, and we show that most of them are stably bound to chromosomes throughout mitosis. Furthermore, in contrast to the random association of BPV1 E2 with mitotic chromosomes, several of these proteins appear to bind to more specific regions of mitotic chromosomes. Using human papillomavirus (HPV) type 8 E2, we show that this region is adjacent to centromeres͞kinetochores. Therefore, E2 proteins from both HPV and animal papillomavirus bind to mitotic chromosomes, and there are variations in the specificity of this binding. Only the ␣-papillomavirus E2 proteins do not stably associate with mitotic chromatin throughout mitosis. These proteins closely associate with prophase chromosomes and bind to chromosomes in telophase but not in metaphase. However, extraction of mitotic cells before fixation results in ␣-E2 proteins binding to the pericentromeric region of metaphase chromosomes, as observed for HPV8 E2. We postulate that this is the authentic target of these E2 proteins but that additional factors or a specialized cellular environment is required to stabilize this association. Thus, E2-mediated tethering of viral genomes to mitotic chromosomes is a common strategy of papillomaviruses, but different viruses have evolved different variations of this theme.human papillomavirus ͉ mitosis ͉ replication ͉ segregation T here are 17 distinct genera of Papillomaviridae (1); each virus infects a specific region of cutaneous or mucosal epithelium in a particular host. For example, human papillomavirus (HPV) types 1, 2, 3, and 4 cause plantar and palmar warts whereas HPV5 and HPV8 are found in cutaneous lesions of epidermodysplasia verruciformis. Mucosal HPV types such as HPV6, HPV11, HPV16, and HPV31 infect genital and sometimes oral epithelia. These infections are usually persistent, and so papillomaviruses need a mechanism to efficiently retain the extrachromosomal genomes within dividing cells.The viral E1 and E2 proteins initiate viral DNA replication by binding to the replication origin. Multiple E2 binding sites are required in addition for the genome to be stably maintained in dividing cells (2). The bovine papillomavirus (BPV) type 1 E2 protein tethers the genomes by means of the E2 binding sites to cellular mitotic chromosomes (3-5) to ensure that they are retained in the nucleus and distributed to daughter cells. This mechanism is a common one in persistent episomal viruses; Epstein-Barr virus and human herpesvirus 8 also each encode a protein that tethers the viral genomes to mitotic chromosomes to ensure their faithful segregation.The E2 protein is also a transcriptional regulator, consisting of a transactivation domain and a dimerization͞DN...

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“…Επιπλέον, αντιγόνο του ιοΰ αυτοΰ έχει ανιχνευτεί και σε ακανθοκυτταρικά καρκι νώματα, σε έρευνες που έγιναν για την εξακρίβωση της παρουσίας του ιοΰ σε διάφορες νεοπλασίες και μη νεο-πλασματικοΰς όγκους του δέρματος 911121314151617 24 .…”

Section: εισαγωγηunclassified

Canine cutaneous papilloma. Study of seven cases.

Kaldrymidou

Papaioannou

Πουταχιδησ)

et al. 2018

J Hellenic Vet Med Soc

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Seven cases of canine papilloma were studied histopathologically using light and electron microscopy. Papillomavirus was detected immunohistochemically and by the polymerase chain reaction (PCR) method. The classical squamous papilloma was found in four dogs (#1,2,3,4), the inverted papilloma in one dog (#5) and the fibropapilloma in two dogs (#6,7).Virus particles were detected electromicroscopically in two cases (#1,2). Immunohistochemistry, revealed the presence of the papillomavirus antigen in three cases (#1,2,3). The PCR method resulted in positive for COPV in two cases (#1,2). These results support the view that except for the canine oral papillomavirus, there might be other types ofpapillomavirus that induce papilloma in dogs.

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Canine Oral Papillomavirus Genomic Sequence: A Unique 1.5-kb Intervening Sequence between the E2 and L2 Open Reading Frames

Cited by 67 publications

References 0 publications

Isolation and cloning of the raccoon (Procyon lotor) papillomavirus type 1 by using degenerate papillomavirus-specific primers

Isolation and cloning of the raccoon (Procyon lotor) papillomavirus type 1 by using degenerate papillomavirus-specific primers

Variations in the association of papillomavirus E2 proteins with mitotic chromosomes

Canine cutaneous papilloma. Study of seven cases.

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