"Canine model of obstructive sleep apnea"

Pack, AI

doi:10.1152/jappl.1994.76.4.1409

Cited by 8 publications

(4 citation statements)

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“…9,10 In the first stage, we developed a relative risk score for apnea. Data for this score are derived from self-reported symptoms of apnea, body mass index (BMI) (obesity is a major risk factor for the disorder), 5,11 age, and sex. 12 In some patients, the risk score will be high enough that the second-stage test is unwarranted, and in others, the risk of apnea is low enough that apnea can be excluded.…”

Section: Introductionmentioning

confidence: 99%

In-Home, Self-Assembled Sleep Studies Are Useful in Diagnosing Sleep Apnea in the Elderly

Morales

Hurley

Wick

et al. 2012

Sleep

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Objectives: Obstructive sleep apnea (OSA) is common and treatable among the elderly. Yet, few older adults seek evaluation for OSA at sleep disorders centers. The authors assessed the feasibility of a two-stage screening procedure for obstructive sleep apnea syndrome (OSAS) in a community-based sample of older adults. Design: Prospective cohort study. Setting: Participants' domicile (in-home) and academic sleep research center. Participants: There were 452 Medicare recipients residing in the greater Philadelphia metropolitan area with the complaint of daytime sleepiness. Interventions: None. Measurements and Results: All participants underwent in-home unattended sleep studies that recorded airflow, and standard in-laboratory polysomnography. Additional measures included symptoms of sleep apnea, body mass index, neck circumference, age, and sex. When comparing diagnostic approaches, the best-performing single-stage model was one that combined apnea symptoms with age and neck circumference. This model had an area under the receiver operating characteristic curve (AUC) of 0.774 and negative posttest probability of 1.2%. The best-performing two-stage model combined symptoms, neck circumference, age, and sex in the first stage, followed by an unattended portable study with a corresponding AUC of 0.85 and negative posttest probability of 0.5%. Conclusions: Unattended, self-assembled, in-home sleep studies recording airflow and respiratory effort are most useful if applied in tandem with clinical data, including a carefully obtained sleep history. This two-stage model is accurate in identifying severe OSAS in older adults and represents a practical diagnostic approach for older adults. Incorporating clinical data was vital and increased accuracy well above that of unattended studies of airflow and effort alone.

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Section: Introductionmentioning

confidence: 99%

In-Home, Self-Assembled Sleep Studies Are Useful in Diagnosing Sleep Apnea in the Elderly

Morales

Hurley

Wick

et al. 2012

Sleep

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“…OSAHS is an increasingly common disorder that is strongly related to overweight and obesity 4,8) ; therefore, overweight and obesity are major risk factors for OSAHS 18) . This study demonstrated that the average AHI of the groups with BMI ≥25 kg/m 2 (groups C and D) was higher than that of the groups with BMI <25 kg/m 2 (groups A and B).…”

Section: Discussionmentioning

confidence: 99%

Obstructive Sleep Apnea‐hypopnea Syndrome Patients with Overweight and Hypertension in a Japanese Workplace

Okabayashi

Kasahara

Uchiyama

et al. 2007

Journal of Occupational Health

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Obstructive Sleep Apnea-hypopnea Syndrome Patients with Overweight andHypertension in a Japanese Workplace: Ken OKABAYASHI, et al. JR East Health Promotion Center, East Japan Railway Company-The objective of this study was to determine the relationship between obstructive sleep apnea-hypopnea syndrome (OSAHS) and overweight combined with hypertension and to examine whether OSAHS in conjunction with overweight and hypertension is associated with daytime sleepiness. In a Japanese workplace of 28,636 employees, 368 men (19-62 yr old), who were anxious regarding their OSAHS symptoms, underwent home pulse oximetry. Of these, 153 men subsequently underwent all-night polysomnography (PSG), and OSAHS was diagnosed in 149. We next classified these 149 men into the following groups:, and D [Overweight (+)/ Hypertension (+), n=47]. The Epworth Sleepiness Scale (ESS) was used to evaluate daytime sleepiness and the apnea-hypopnea index (AHI) was used to evaluate the severity of OSAHS. The averages of the ESS score and the AHI were compared in each group. Both the average ESS scores and the percentage of ESS scores ≥11 were not significantly different among the groups. The average AHI of group D was the highest among all of the groups and that of group C was significantly higher than those of groups A and B. In all the groups, the OSAHS patients with overweight and hypertension in this study had the highest AHI. The level of daytime sleepiness evaluated by the ESS in this study was almost the same in the OSAHS patients regardless of the degree of overweight or hypertension. These observations suggest that it is necessary to positively recommend PSG to men who are suspected of having OSAHS with overweight and hypertension, even if they do not have daytime sleepiness. Accumulating evidence has suggested that obstructive sleep apnea-hypopnea syndrome (OSAHS) is not only a phenomenon of the cessation of breathing during sleep but also the cause of sleepiness during the day and various other physical disorders [1][2][3] . Moreover, neurocognitive sequelae, such as daytime sleepiness and impaired executive function, are important factors implicated in motor vehicle accidents and probably contribute to the loss of work-related productivity 4) . The true prevalence of OSAHS in Japan has not been established. A community-based study of sleep apnea in middle-aged Chinese men (30-60 yr old) residing in Hong Kong used full polysomnography (PSG) and demonstrated an estimated 4.1% prevalence of OSAHS 5) . Most population-based studies that have estimated the sexspecific prevalence indicate a greater risk of OSAHS in men than in women 6) . Thus, OSAHS is common in adult males and remains an important public health problem. However, many people with OSAHS remain undiagnosed and untreated because the symptoms of OSAHS, such as snoring and cessation of breathing, are not necessarily

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“…3 The clinical sequelae of untreated OSA syndrome are often severe and include daytime hypersomnolence, cognitive impairment, systemic hypertension, pulmonary hypertension, myocardial infarction, cardiac arrhythmias, and increased risk of motor vehicle crashes. 4,5 Unfortunately, the majority of patients with OSA syndrome remain undiagnosed and untreated. 6 …”

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confidence: 99%