Canine model for surgical correction of chronic venous hypertension

Lalka, Stephen G.; Malone, James M.; Cosentino, Catherine; Reinert, Richard L.; Bernhard, Victor M.

doi:10.1016/0022-4804(88)90178-3

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Animal models of CVI have been established using dogs (Lalka et al, 1988), swine (Jones et al, 2009), rabbits (Sawchuk et al, 1987), and rats (Pascarella et al, 2005). In these animal models, the venous pressure gradually decreases due to the open collateral circulation of the venous branches.…”

Section: Discussionmentioning

confidence: 99%

Applied Anatomy of the Femoral Veins in Macaca fascicularis

Zhang

Xiong

et al. 2012

Int. J. Morphol.

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Section: Discussionmentioning

confidence: 99%

Applied Anatomy of the Femoral Veins in Macaca fascicularis

Zhang

Xiong

et al. 2012

Int. J. Morphol.

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“…In a greyhound, ligation of the external and internal iliac veins in addition to all side branches to just above the caudal femoral vein resulted in elevated distal venous pressures at rest and during exercise that was sustained for at least 15 weeks. 8 Lower limb edema resolved by 6 weeks but there was increased venous patterning over the lower abdomen. Several short-term (Յ4 hours) studies using this model have clarified some aspects of the surgical treatment of venous occlusive disease.…”

Section: Literature Review Obstructive Modelsmentioning

confidence: 99%

“…11 An isodiametric cross femoral vein bypass using external jugular vein in addition to a sequential AVF resulted in a normalization of resting and postexercise distal venous pressures by 6 weeks and maintained this improvement after AVF ligation (follow-up 6 weeks). 8 This model appears acceptable for investigating several aspects of the surgical treatment of chronic venous occlusive disease. Furthermore, studies already performed with this model clearly suggest that an isodiametric graft is required to maintain normal venous hemodynamics and that a dAVF of moderate flow may be helpful to maintain early patency.…”

Section: Literature Review Obstructive Modelsmentioning

confidence: 99%

Animal Models for the Study of Lower Extremity Chronic Venous Disease: Lessons Learned and Future Needs

Dalsing

Ricotta

Wakefield

et al. 1998

Annals of Vascular Surgery

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The purpose of this review is to define animal models of chronic venous disease and to demonstrate how animal studies can impact our understanding and treatment of this disorder. To this end an extensive literature search was conducted highlighting potential animal models of chronic lower extremity venous disease. Scientific investigations using animals to study particular aspects of this disease are also reviewed. This review was conducted by members of the Committee on Research of the American Venous Forum to help provide direction for future venous research endeavors. Useful models of chronic venous occlusive disease involve controlled ligation of a major lower limb vein and multiple tributaries. Such a model can provide sustained venous hypertension and studies using this model have confirmed that an isodiametric graft can provide early hemodynamic relief. Models of primary, postphlebitic, and isolated chronic deep venous insufficiency are available for study. Valve repair or transplantation can positively impact the insufficiency observed in these models. Investigations into valve substitutes have generally been disappointing or are undergoing early evaluation. In conclusion, animal models for the study of some aspects of chronic venous disease do exist and have already affected our clinical approach to patients. The scientific study of basic pathophysiology, diagnostics, end-organ response, and long-term surgical treatments of this disorder in well-controlled animal experiments have not been conducted.

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