2006
DOI: 10.1111/j.1439-0442.2006.00869.x
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Canine Leishmaniasis Chemotherapy: Dog's Clinical Condition and Risk of Leishmania Transmission

Abstract: The aim of this study was to investigate whether treatment against canine leishmaniasis reduced the presence of Leishmania in the healthy skin of dogs, affecting the capacity of parasite transmission. A total of 37 dogs from an endemic region of leishmaniasis were studied. Thirteen symptomatic animals revealed parasites in the bone marrow and eight had also in the skin. Five of the 22 dogs that had been treated with meglumine antimoniate alone, meglumine antimoniate or trifluralin followed by allopurinol or ju… Show more

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Cited by 17 publications
(6 citation statements)
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References 31 publications
(28 reference statements)
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“…Different drugs and protocols have been proposed for CanL treatment (5). Following treatment parasitological healing is possible, but not frequent (6)(7)(8); after a temporary remission of clinical signs, disease recurrence can be seen (6,(9)(10)(11)(12)(13). N-methylglucamine antimoniate (MA) and miltefosine (MIL) both combined with allopurinol are first-line drug therapies (6,(14)(15)(16)(17).…”
Section: Introductionmentioning
confidence: 99%
“…Different drugs and protocols have been proposed for CanL treatment (5). Following treatment parasitological healing is possible, but not frequent (6)(7)(8); after a temporary remission of clinical signs, disease recurrence can be seen (6,(9)(10)(11)(12)(13). N-methylglucamine antimoniate (MA) and miltefosine (MIL) both combined with allopurinol are first-line drug therapies (6,(14)(15)(16)(17).…”
Section: Introductionmentioning
confidence: 99%
“…CanL conventional treatments improve the dog's clinical condition, reducing skin parasite load and consequently the risk of Leishmania transmission. Although it is not definitively proved that treatment completely eliminates the parasite (11), and relapses are common when therapy is discontinued (3, 11, 12) it remains crucial to improve the efficiency of protocols used for CanL treatment. The main protocols for dog treatment usually include meglumine antimoniate (N-methylglucamine antimoniate), miltefosine (1-O-hexadecylphosphocholine), and allopurinol.…”
Section: Introductionmentioning
confidence: 99%
“…Dog treatment with chemotherapy based on meglumine antimoniate and allopurinol is the current standard to control leishmaniasis [17, 18]. In the model this strategy is simulated by varying the rate ω in the fifth and seventh equations, such that infected dogs are removed from the infectious compartment and are transferred to the susceptible compartment.…”
Section: Resultsmentioning
confidence: 99%