Canine Extracutaneous Mast-cell Tumours Consisting of Connective Tissue Mast Cells

Iwata, Naoko; Ochiai, Kenji; Kadosawa, Tsuyoshi; Takiguchi, M.; Umemura, Takashi

doi:10.1053/jcpa.2000.0420

Cited by 15 publications

(14 citation statements)

References 7 publications

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“…2 Among previous reports on MCTs originating in the gastrointestinal tract, only one report specified the origin of the mast cells. 4 In that case, the MCT may have originated from CTMCs, based on heparin immunostaining and electron microscopic features. In another previous report, 17 certain characteristics of intestinal MCTs were similar to those of MMCs, but the derivation of mast cells was not clearly specified.…”

Section: Discussionmentioning

confidence: 99%

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Mast Cell Tumors of the Gastrointestinal Tract in 39 Dogs

et al. 2002

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Abstract. Mast cell tumors (MCTs) of gastrointestinal origin that had been surgically removed from 39 dogs were examined to evaluate their pathologic features. Miniature breeds, especially Maltese, were most frequently affected. The average age of affected dogs was 9.7 Ϯ 2.6 years. No sex difference was apparent. The most frequently affected sites were in the upper digestive tract, and the prognosis was very poor. Grossly, the gastrointestinal wall was prominently thickened, and the lumen of the affected gut was usually narrowed. Microscopically, there was diffuse transmural invasion of round to pleomorphic tumor cells. Tumor cells had moderate to abundant cytoplasm, round to ovoid nuclei with scattered chromatin, and mitotic figures. Fibrous stroma was observed in about half of the tumors. There was variable infiltration of eosinophils. In all tumors, cytoplasmic granules showed weak metachromasia, but the number of granules was very small. Immunohistochemical staining for c-kit and mast cell tryptase was positive in 77% and 62% of tumors, respectively. All tumors were positive for at least two of these markers. Immunohistochemical staining for p53 was positive in 13% of the tumors. Reactivity for staining markers and p53 was unrelated to cell pleomorphism, vessel invasion, or survival time. Gastrointestinal MCTs have histologic and immunohistochemical features completely different from those of other primary or metastatic gastrointestinal tumors. The combination of immunostaining for mast cell tryptase and c-kit and histochemical staining for metachromasia appears to be a powerful tool for the diagnosis of gastrointestinal MCTs.

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Section: Discussionmentioning

confidence: 99%

“…4,12,17 Malignant lymphoma is the most common gastrointestinal tumor of hematopoietic cell origin in dogs. Recently, we encountered tumor masses consisting of small round individual cells in miniature breed dogs, especially Maltese.…”

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confidence: 99%

Mast Cell Tumors of the Gastrointestinal Tract in 39 Dogs

et al. 2002

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“…In the available literature, there are no previous reports of a primary MCT of the canine tonsil. Extracutaneous MCTs occur in dogs and may rarely involve the oral cavity, with reported locations including the lip, gingiva, salivary gland, palate and tongue . MCTs have been reported to account for 0–5% of canine oral neoplasms .…”

Section: Discussionmentioning

confidence: 99%

Primary tonsillar mast cell tumour in a dog

Shekell¹,

Thomson²,

et al. 2018

Aust Veterinary J

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“…While cutaneous MCTs are common neoplasms among dogs, accounting for 16 to 21 per cent of all skin tumours in dogs in the USA (Thamm and Vail 2001), gastrointestinal MCTs are much less common and their pathological features are to a certain degree still unclear (Ozaki and others 2002). Visceral MCTs are rarely described and usually affect miniature purebreed dogs, such as Maltese or Pomeranians (Takahashi and others 2000, Ozaki and others 2002), although a visceral MCT has previously been described in a golden retriever (Iwata and others 2000).…”

Section: Discussionmentioning

confidence: 99%

Lomustine for the treatment of gastrointestinal mast cell tumour in a dog

Baldi¹,

Colloca

Spugnini³

2006

J of Small Animal Practice

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An eight-year-old, male boxer dog was referred for the treatment of a large (5.5 x 5 cm), unresectable visceral mast cell tumour. The dog had a surgical resection performed one month before referral, and it had widespread metastases to the abdominal lymph nodes. The patient was treated with lomustine and prednisone and showed a rapid improvement and increased level of activity, weight gain and consistent tumour reduction. The patient remained in partial remission (defined as a greater than 50 per cent reduction in tumour volume) for seven months. Toxicity was acceptable and was limited to moderate anaemia and two episodes of neutropenia. At the completion of the seven months of therapy, the dog experienced a chemotherapy-induced sepsis, and the owners elected for euthanasia due to financial concerns. At that time, the tumour was still in partial remission. This case report suggests that a combination of lomustine and prednisone is an effective protocol for the palliation of aggressive visceral mast cell tumours.

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Canine Extracutaneous Mast-cell Tumours Consisting of Connective Tissue Mast Cells

Cited by 15 publications

References 7 publications

Mast Cell Tumors of the Gastrointestinal Tract in 39 Dogs

Mast Cell Tumors of the Gastrointestinal Tract in 39 Dogs

Primary tonsillar mast cell tumour in a dog

Lomustine for the treatment of gastrointestinal mast cell tumour in a dog

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