Canine Acute Phase Response: Relationship between Serum Cytokine Activity and Acute Phase Protein in Dogs.

Yamashita, Kazuto; Fujinaga, Toru; Miyamoto, Toru; Hagio, Mitsuyoshi; Izumisawa, Yasuharu; Kotani, Tadao

doi:10.1292/jvms.56.487

Cited by 68 publications

(69 citation statements)

References 23 publications

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“…No significant difference was observed with regard to sex, and both sexes had lower mean values than those obtained from dogs with inflammatory diseases [3,6,10,21,24,28], matching well with previously reported values [3,6]. Thus, the results of our study suggest that we did indeed obtain physiological AAG levels in healthy beagles.…”

Section: Discussionsupporting

confidence: 91%

Alpha 1-Acid Glycoprotein (AAG) Levels in Healthy and Pregrant Beagle Dogs

et al. 2003

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Abstract. Serum alpha 1-acid glycoprotein (AAG) levels were measured in healthy beagles of various ages (66 male and 74 female) by turbidimetric immunoassay (TIA), and then separately -in pregnant beagles -by single radial immunodiffusion (SRID). The first experiment revealed that serum AAG levels ranged from 40 to 960 µg/ml (mean of 322 ± 202 µg/ml) in male dogs, and from 47 to 833 µg/ml -in female dogs (mean of 316 ± 199 µg/ ml), without any significant sex-or age-related variation. The second experiment, however, revealed that serum AAG levels increased in all pregnant beagles and peaked in the middle of gestation at 250-1,000 µg/ml (mean of 634 ± 246 µg/ml). In 7 of 8 dogs the AAG levels peaked about 45 days after ovulation. Despite a high value of 1,210-1,360 µg/ml being observed for serum AAG levels in 3 pregnant beagles inoculated with Staphylococcus aureus, its levels in umbilical cord blood were below the detection limit of SRID (40 µg/ml).

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Section: Discussionsupporting

confidence: 91%

Alpha 1-Acid Glycoprotein (AAG) Levels in Healthy and Pregrant Beagle Dogs

et al. 2003

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“…The correlation of the CRP concentration with body temperature and WBC counts in dogs with experimentally induced inflammation has been reported [20]; however, statistical analysis in clinical patients has not been performed. Although we examined numerous clinical patients in this study, only a weak correlations of CRP concentration with WBC counts was observed and no correlation was observed with band neutrophil counts.…”

Section: Discussionmentioning

confidence: 99%

“…), and nephrotic syndrome, which often cause protein loss, a weak negative correlation was observed. A previous study had also reported that albumin concentration decreases in dogs with experimentally induced inflammation [20]. However, as albumin concentration is affected by dehydration and malnutrition in canine patients, it would be difficult to be used it as an inflammatory marker in a clinical setting.…”

Section: Discussionmentioning

confidence: 99%

“…However, in veterinary medicine, CRP levels have not been widely examined in routine tests, and there are no thorough studies concerning CRP concentration in disease. Furthermore, comparison between CRP and other inflammatory markers, including white blood cell (WBC) counts, neutrophil counts, and body temperature has only been performed in a limited number of cases [2,20], and the clinical significance of CRP remains unknown.…”

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confidence: 99%

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C-Reactive Protein Concentration in Dogs with Various Diseases

et al. 2008

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ABSTRACT. To investigate the clinical utility of C-reactive protein (CRP) determination in dogs, its plasma concentration was measured by a laser nephelometric method in 928 dogs with various diseases, and was compared with other inflammatory parameters. CRP concentration was elevated in various inflammatory diseases, this was most frequently observed in cases with neoplastic and immune-mediated diseases. All cases of pyometra, panniculitis, acute pancreatitis, polyarthritis, and hemangiosarcoma showed significantly elevated CRP concentrations. On the other hand, the CRP concentration was elevated only in few cases of neurological diseases such as epilepsy, meningoencephalitis, and hydrocephalus and endocrine diseases such as hypothyroidism, hyperadrenocorticism, and diabetes mellitus. Only a weak correlation was observed between the CRP concentration and white blood cell (WBC) counts (r=0.44) but no correlation with band neutrophil counts. There was no correlation between the CRP and albumin concentrations, but a weak negative correlation (r=-0.40) when excluding chronic intestinal diseases and nephrotic syndrome, which can cause protein loss. Thus, CRP can be useful to detect inflammations that cannot be detected by WBC and, or band neutrophil counts, suggesting that the examination of CRP concentration is essential as routine diagnostic test. KEY WORDS: albumin, C-reactive protein (CRP), canine, neutrophil, WBC.

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“…47 Serum CRP concentrations may increase more than 1,000-fold in response to the release of proinflammatory cytokines, most prominently interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), from macrophages at the site of inflammatory lesions or infection. 45 Thus, CRP is well recognized as a sensitive systemic marker of the nonspecific acute phase response to most forms of tissue damage and inflammation in human beings, dogs, and pigs. 6,9,32 In dogs, several studies have described increased levels of serum CRP in response to a variety of pathological conditions, including infectious diseases, traumata, surgery, systemic inflammatory response syndrome, or immunemediated diseases.…”

Section: Introductionmentioning

confidence: 99%

C-reactive protein concentrations in serum of dogs with naturally occurring renal disease

2011

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The current study was undertaken to investigate the relation between serum C-reactive protein (CRP) concentrations and parameters of renal function in dogs with naturally occurring renal disease. Dogs were assigned to groups according to plasma creatinine concentration, urinary protein-to-creatinine ratio (UP/UC), and exogenous plasma creatinine clearance (P-ClCr) rates. Group A (healthy control dogs; n = 8): non-azotemic (plasma creatinine <125 µmol/l) and nonproteinuric (UP/UC <0.2), with P-ClCr rates >90 ml/min/m2; group B (n = 11): non-azotemic, nonproteinuric dogs with reduced P-ClCr rates (50–89 ml/min/m2); group C (n = 7): azotemic, borderline proteinuric dogs (P-ClCr rates: 22–67 ml/min/m2); and group D (n = 6): uremic, proteinuric dogs (not tested for P-ClCr). The serum CRP concentrations were measured via commercial enzyme-linked immunosorbent assay. The CRP concentrations in the clinically healthy dogs (group A) ranged from 2.09 mg/l to 8.60 mg/l (median: 3.21 mg/l). In comparison with dogs of group A, median CRP concentrations were significantly ( P < 0.01) elevated in dogs of group B (17.6 mg/l, range: 17.0–19.2 mg/l), group C (24.8 mg/l, range: 18.0–32.5 mg/l), and group D (59.7 mg/l, range: 17.7–123 mg/l). Serum CRP was significantly related to P-ClCr ( r = –0.83; P < 0.001), plasma creatinine ( r = 0.81; P < 0.001), UP/UC ( r = 0.70; P < 0.001), and leukocytes ( r = 0.49; P < 0.01). The significant relations between serum CRP concentrations and biochemical parameters of kidney function in plasma and urine suggest that a stimulation of the acute phase response is implicated in the pathogenesis of canine renal disease.

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Canine Acute Phase Response: Relationship between Serum Cytokine Activity and Acute Phase Protein in Dogs.

Cited by 68 publications

References 23 publications

Alpha 1-Acid Glycoprotein (AAG) Levels in Healthy and Pregrant Beagle Dogs

Alpha 1-Acid Glycoprotein (AAG) Levels in Healthy and Pregrant Beagle Dogs

C-Reactive Protein Concentration in Dogs with Various Diseases

C-reactive protein concentrations in serum of dogs with naturally occurring renal disease

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